Medicine Information

Timozin

Name: Timozin
Brand: Timozin
Rating: 4.5 (117 reviews)

Injection5 mgBeta-adrenergic Blocker (Non-selective)ATC: C07AA06

Generic Name

Timozin 5 mg Injection

Manufacturer

MediCorp Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
timozin 5 mg injection	৳ 35.00	N/A

Description

Overview of the medicine

Timozin 5 mg Injection contains a beta-adrenergic blocker indicated for the management of various cardiovascular conditions such as hypertension and arrhythmias. It acts by blocking beta-receptors in the heart and blood vessels.

Uses & Indications

Management of hypertension (especially in hypertensive emergencies)

Treatment of certain cardiac arrhythmias

Prophylaxis of angina pectoris

Dosage

Adults

Initial dose 5 mg IV, administered slowly over 5-10 minutes. May be repeated after 2-4 hours if necessary, up to a maximum daily dose of 20 mg.

Elderly

Dose adjustments may be required, starting with a lower dose and monitoring closely due to potential age-related organ impairment.

Renal_impairment

No specific dose adjustment for mild to moderate renal impairment. Use with caution in severe renal impairment, monitor for adverse effects.

How to Take

Administer intravenously slowly over 5-10 minutes by a healthcare professional. Do not administer intramuscularly or subcutaneously.

Mechanism of Action

Timozin works by competitively blocking beta1 and beta2 adrenergic receptors. This results in decreased heart rate, reduced myocardial contractility, and lower blood pressure, thereby managing conditions like hypertension and cardiac arrhythmias.

Pharmacokinetics

Onset

Within minutes (IV)

Excretion

Excreted mainly via urine, both as unchanged drug and metabolites.

Half life

Approximately 4-6 hours

Absorption

Rapidly and completely absorbed following intravenous administration.

Metabolism

Primarily hepatic metabolism

Side Effects

Contraindications

Bronchial asthma or severe COPD
Sinus bradycardia (heart rate < 45-50 bpm)
Second or third-degree atrioventricular block
Cardiogenic shock
Decompensated heart failure

Drug Interactions

NSAIDs

May reduce antihypertensive effect.

Digitalis Glycosides

Increased risk of bradycardia and AV block.

Calcium Channel Blockers (e.g., Verapamil, Diltiazem)

Increased risk of bradycardia and hypotension.

Storage

Store below 30°C. Protect from light. Do not freeze.

Overdose

Symptoms include severe bradycardia, hypotension, bronchospasm, and acute cardiac failure. Management involves supportive measures, atropine for bradycardia, vasopressors for hypotension, and glucagon for refractory cases.

Pregnancy & Lactation

Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Beta-blockers can cross the placenta and may cause bradycardia and hypoglycemia in the neonate. Excreted in breast milk; use with caution.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 x 5 mL vial5 x 5 mL vials (multipack)

Shelf Life

24 months from the date of manufacture

Availability

Hospitals, Clinics, Retail Pharmacies

Approval Status

Approved by regulatory authorities (e.g., DGDA)

Patent Status

Patent Expired (Generic available)

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have demonstrated the efficacy and safety of beta-blockers in managing hypertension and arrhythmias. Specific trials for Timozin injection may vary by region.

Lab Monitoring

Blood pressure monitoring
Heart rate monitoring
ECG monitoring (especially in critical care settings)
Renal function tests (periodically)

Doctor Notes

Always assess patient's cardiac function and comorbidities before administration.
Monitor vital signs closely during and after injection.
Be prepared to manage acute adverse reactions, especially severe bradycardia or hypotension.

Patient Guidelines

This medication is administered by a healthcare professional.
Report any discomfort, dizziness, or difficulty breathing immediately.
Do not stop the medication abruptly without consulting your doctor (if transitioning to oral).

Missed Dose Advice

As this is an injection administered by a healthcare professional, missed doses are unlikely in a controlled setting. If a scheduled dose is missed, inform the medical staff immediately.

Driving Precautions

As an injectable medication usually administered in a hospital setting, driving immediately after administration is generally not applicable. However, the drug can cause dizziness and fatigue, so caution should be exercised if discharged and driving later.