Traxon
Generic Name
Ceftriaxone
Manufacturer
Multiple manufacturers (e.g., Square Pharmaceuticals Ltd. in Bangladesh)
Country
Global (Manufactured in various countries)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| traxon 2 gm injection | ৳ 350.00 | N/A |
Description
Overview of the medicine
Traxon 2 gm Injection contains Ceftriaxone, a broad-spectrum third-generation cephalosporin antibiotic. It is used to treat a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
Typically 1-2 gm once daily intravenously or intramuscularly, or 0.5-1 gm every 12 hours for severe infections; up to 4 gm/day.
Elderly
No specific dosage adjustment usually required unless severe renal or hepatic impairment.
Renal_impairment
No dosage adjustment needed for mild to moderate impairment. For severe impairment (CrCl < 10 mL/min), maximum dose should not exceed 2 gm daily.
How to Take
For intravenous (IV) administration, reconstitute with sterile water for injection and infuse slowly over 30 minutes. For intramuscular (IM) administration, reconstitute with lidocaine 1% (without epinephrine) and inject deep into a large muscle.
Mechanism of Action
Ceftriaxone inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Rapid, within minutes after IV administration.
Excretion
Approximately 50-60% excreted unchanged in urine and 40-50% in bile/feces.
Half life
Approximately 5.8 to 8.7 hours (prolonged in neonates and elderly).
Absorption
Rapid and complete absorption after intramuscular administration; IV administration provides immediate bioavailability.
Metabolism
Limited hepatic metabolism; primarily metabolized to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to ceftriaxone, any cephalosporins, or penicillin
- Neonates with hyperbilirubinemia, especially premature neonates
- Concomitant use with IV calcium-containing solutions in neonates
Drug Interactions
Loop diuretics
Increased risk of nephrotoxicity with high doses of ceftriaxone.
Aminoglycosides
Synergistic effect against some organisms, but administer separately to avoid precipitation.
Oral anticoagulants
May increase the anticoagulant effect. Monitor INR/PT.
Calcium-containing solutions
Contraindicated in neonates; in older patients, flush lines between administration.
Storage
Store below 30°C. Protect from light. Reconstituted solution should be used immediately or within 6 hours if refrigerated.
Overdose
Overdose symptoms may include nausea, vomiting, and diarrhea. In severe cases, neurological symptoms (e.g., seizures) can occur. Treatment is symptomatic and supportive. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy only if clearly needed. Excreted in breast milk in small amounts; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to ceftriaxone, any cephalosporins, or penicillin
- Neonates with hyperbilirubinemia, especially premature neonates
- Concomitant use with IV calcium-containing solutions in neonates
Drug Interactions
Loop diuretics
Increased risk of nephrotoxicity with high doses of ceftriaxone.
Aminoglycosides
Synergistic effect against some organisms, but administer separately to avoid precipitation.
Oral anticoagulants
May increase the anticoagulant effect. Monitor INR/PT.
Calcium-containing solutions
Contraindicated in neonates; in older patients, flush lines between administration.
Storage
Store below 30°C. Protect from light. Reconstituted solution should be used immediately or within 6 hours if refrigerated.
Overdose
Overdose symptoms may include nausea, vomiting, and diarrhea. In severe cases, neurological symptoms (e.g., seizures) can occur. Treatment is symptomatic and supportive. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy only if clearly needed. Excreted in breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, check specific product labeling.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies worldwide (e.g., FDA, DGDA)
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established ceftriaxone's efficacy and safety for various bacterial infections since its introduction.
Lab Monitoring
- Renal function (BUN, creatinine)
- Liver function (ALT, AST)
- Complete blood count (CBC) with differential
- INR/PT if on anticoagulants
Doctor Notes
- Crucial to ascertain penicillin allergy status before administration.
- Monitor for signs of C. difficile infection if prolonged diarrhea occurs.
- Administer slowly, especially IV, to reduce venipuncture site discomfort.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Report any severe diarrhea or allergic reactions immediately.
- Do not self-medicate or share this medication with others.
Missed Dose Advice
If a dose is missed, administer it as soon as possible. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness; caution advised when driving or operating machinery.
Lifestyle Advice
- Maintain good hydration.
- Practice good hygiene to prevent further infections.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Traxon Brand
Other medicines available under the same brand name
