Traxon
Generic Name
Ceftriaxone
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| traxon 250 mg injection | ৳ 100.00 | N/A |
Description
Overview of the medicine
Traxon 250 mg Injection contains Ceftriaxone, a third-generation cephalosporin antibiotic. It is used to treat a wide range of bacterial infections by stopping the growth of bacteria. It is administered via intramuscular or intravenous route.
Uses & Indications
Dosage
Adults
Adults: Usually 1-2 g once daily. For Traxon 250 mg, it is generally used for mild infections or specific pediatric indications, often 50-75 mg/kg/day divided every 12-24 hours for children. Consult specific guidelines for precise dosing.
Elderly
No specific dose adjustment is needed in the elderly unless there is severe renal or hepatic impairment.
Renal_impairment
In severe renal impairment (creatinine clearance <10 mL/min) without hemodialysis, the total daily dose should not exceed 2 g.
How to Take
Traxon 250 mg Injection should be administered by deep intramuscular injection or slow intravenous infusion (over 30 minutes) or slow intravenous injection (over 2-4 minutes). It should be reconstituted with the provided solvent (e.g., Water for Injection, Lidocaine HCl solution).
Mechanism of Action
Ceftriaxone acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), which are essential for the synthesis of peptidoglycan, a key component of the bacterial cell wall. This inhibition leads to defective cell wall formation and subsequent bacterial lysis.
Pharmacokinetics
Onset
Rapid onset of action, particularly after intravenous administration.
Excretion
Excreted through both renal (glomerular filtration) and biliary pathways.
Half life
Approximately 6-9 hours in healthy adults; can be prolonged in neonates, elderly, and those with severe renal or hepatic impairment.
Absorption
Rapid and complete absorption after intramuscular (IM) or intravenous (IV) administration. Peak plasma concentrations are reached within 2-3 hours after IM injection.
Metabolism
Not extensively metabolized in the liver; approximately 33-67% of the dose is excreted unchanged in urine, and the remainder is excreted via bile.
Side Effects
Contraindications
- Known hypersensitivity to ceftriaxone, other cephalosporins, or any component of the formulation.
- History of severe hypersensitivity reaction to any other type of beta-lactam antibacterial agents (e.g., penicillins, monobactams, carbapenems).
- Hyperbilirubinemic neonates, especially premature neonates (due to risk of bilirubin encephalopathy).
Drug Interactions
Aminoglycosides
Synergistic effect against some bacteria, but physically incompatible in syringe/infusion bottle. Should be administered separately.
Oral Contraceptives
May reduce the effectiveness of oral contraceptives; additional birth control methods may be required.
Calcium-containing solutions
Contraindicated in neonates; in other age groups, simultaneous administration should be avoided.
Loop Diuretics (e.g., Furosemide)
May increase nephrotoxicity when co-administered with other nephrotoxic drugs.
Oral Anticoagulants (e.g., Warfarin)
Increased risk of bleeding due to inhibition of vitamin K synthesis or displacement from plasma protein binding.
Storage
Store the dry powder below 30°C, protected from light and moisture. After reconstitution, the solution is stable for 6 hours at room temperature (25°C) or 24 hours under refrigeration (2-8°C). Do not freeze.
Overdose
In case of overdose, symptoms may include nausea, vomiting, diarrhea, and possibly neurological effects. Treatment should be symptomatic and supportive. There is no specific antidote. Ceftriaxone is not dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. Human studies are limited, but it is generally considered safe during pregnancy when clearly needed. Ceftriaxone is excreted in low concentrations in breast milk; caution should be exercised when administered to a nursing mother. Monitor for diarrhea or candidiasis in breastfed infants.
Side Effects
Contraindications
- Known hypersensitivity to ceftriaxone, other cephalosporins, or any component of the formulation.
- History of severe hypersensitivity reaction to any other type of beta-lactam antibacterial agents (e.g., penicillins, monobactams, carbapenems).
- Hyperbilirubinemic neonates, especially premature neonates (due to risk of bilirubin encephalopathy).
Drug Interactions
Aminoglycosides
Synergistic effect against some bacteria, but physically incompatible in syringe/infusion bottle. Should be administered separately.
Oral Contraceptives
May reduce the effectiveness of oral contraceptives; additional birth control methods may be required.
Calcium-containing solutions
Contraindicated in neonates; in other age groups, simultaneous administration should be avoided.
Loop Diuretics (e.g., Furosemide)
May increase nephrotoxicity when co-administered with other nephrotoxic drugs.
Oral Anticoagulants (e.g., Warfarin)
Increased risk of bleeding due to inhibition of vitamin K synthesis or displacement from plasma protein binding.
Storage
Store the dry powder below 30°C, protected from light and moisture. After reconstitution, the solution is stable for 6 hours at room temperature (25°C) or 24 hours under refrigeration (2-8°C). Do not freeze.
Overdose
In case of overdose, symptoms may include nausea, vomiting, diarrhea, and possibly neurological effects. Treatment should be symptomatic and supportive. There is no specific antidote. Ceftriaxone is not dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. Human studies are limited, but it is generally considered safe during pregnancy when clearly needed. Ceftriaxone is excreted in low concentrations in breast milk; caution should be exercised when administered to a nursing mother. Monitor for diarrhea or candidiasis in breastfed infants.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Generally 2-3 years for the unopened vial. Refer to the manufacturer's specific product labeling for exact shelf life and reconstituted solution stability.
Availability
Available in hospitals, clinics, and pharmacies.
Approval Status
Approved worldwide
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Ceftriaxone has undergone extensive clinical trials since its development, establishing its efficacy and safety in various bacterial infections. Ongoing research explores its role in antibiotic resistance patterns and new therapeutic combinations.
Lab Monitoring
- Complete Blood Count (CBC) including differential (monitor for hematologic abnormalities)
- Renal function tests (blood urea nitrogen, creatinine)
- Liver function tests (AST, ALT, bilirubin) periodically during prolonged therapy
- Coagulation parameters (e.g., PT/INR) if co-administered with anticoagulants
Doctor Notes
- Broad-spectrum cephalosporin effective against many Gram-positive and Gram-negative bacteria.
- Useful for empiric therapy in severe infections pending culture results.
- Caution advised when co-administering with calcium-containing solutions, especially in neonates.
- Monitor for signs of C. difficile-associated diarrhea (CDAD) during and after treatment.
Patient Guidelines
- Complete the full course of antibiotic treatment as prescribed by your doctor, even if your symptoms improve.
- Do not share this medicine with others, and do not use it to treat other infections.
- Report any unusual side effects or worsening of your condition to your doctor immediately.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
Missed Dose Advice
If a dose is missed, administer it as soon as you remember, unless it is almost time for the next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Ceftriaxone generally has no or negligible influence on the ability to drive and use machines. However, if side effects such as dizziness or headaches occur, patients should avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Avoid alcohol consumption during the treatment period as it may exacerbate some side effects.
- Rest adequately to aid recovery from infection.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Traxon Brand
Other medicines available under the same brand name
