Trialon
Generic Name
Triamcinolone Acetonide
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| trialon 40 mg injection | ৳ 75.25 | N/A |
Description
Overview of the medicine
Trialon 40 mg Injection contains Triamcinolone Acetonide, a synthetic corticosteroid. It is used to treat various inflammatory and autoimmune conditions by suppressing the immune system and reducing inflammation.
Uses & Indications
Dosage
Adults
Intramuscular injection: 40-80 mg once every 1-6 weeks, depending on the condition and patient response. Intra-articular/Intrabursal: 5-40 mg.
Elderly
Lower doses may be considered; caution with co-morbidities.
Renal_impairment
No specific dosage adjustment required, but caution is advised.
How to Take
For intramuscular, intra-articular, intrabursal, or intralesional injection only. Not for intravenous use. Administer deeply into the gluteal muscle for IM use. Shake well before use.
Mechanism of Action
Triamcinolone Acetonide binds to glucocorticoid receptors, modifying gene expression and leading to multiple anti-inflammatory and immunosuppressive effects. It inhibits prostaglandin and leukotriene synthesis, reduces capillary permeability, and stabilizes lysosomal membranes.
Pharmacokinetics
Onset
Within hours, full effect may take days for depot injection.
Excretion
Excreted mainly in urine, with some fecal excretion.
Half life
Biological half-life is approximately 18-36 hours; plasma half-life is shorter.
Absorption
Well absorbed after intramuscular injection, providing sustained release. Peak plasma levels usually occur within 8-24 hours.
Metabolism
Primarily metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to Triamcinolone or any component
- Live or live-attenuated vaccines during high-dose corticosteroid therapy
Drug Interactions
NSAIDs
Increased risk of gastrointestinal ulceration.
Warfarin
Effects may be altered; monitor INR.
Diuretics (thiazide, loop)
May enhance potassium depletion.
Insulin/Oral hypoglycemics
May increase blood glucose, requiring dose adjustments.
Phenytoin, Carbamazepine, Rifampin, Barbiturates
May increase corticosteroid metabolism, reducing its effect.
Storage
Store at controlled room temperature (20°C to 25°C). Protect from freezing. Do not refrigerate. Keep out of reach of children.
Overdose
Acute overdose is rare. Chronic overdose can lead to Cushing's syndrome, adrenal suppression. Management includes symptomatic and supportive care, gradual dose reduction.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs potential risk to the fetus. Corticosteroids are excreted in breast milk; caution advised, weighing benefits vs. risks.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to Triamcinolone or any component
- Live or live-attenuated vaccines during high-dose corticosteroid therapy
Drug Interactions
NSAIDs
Increased risk of gastrointestinal ulceration.
Warfarin
Effects may be altered; monitor INR.
Diuretics (thiazide, loop)
May enhance potassium depletion.
Insulin/Oral hypoglycemics
May increase blood glucose, requiring dose adjustments.
Phenytoin, Carbamazepine, Rifampin, Barbiturates
May increase corticosteroid metabolism, reducing its effect.
Storage
Store at controlled room temperature (20°C to 25°C). Protect from freezing. Do not refrigerate. Keep out of reach of children.
Overdose
Acute overdose is rare. Chronic overdose can lead to Cushing's syndrome, adrenal suppression. Management includes symptomatic and supportive care, gradual dose reduction.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs potential risk to the fetus. Corticosteroids are excreted in breast milk; caution advised, weighing benefits vs. risks.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date when stored correctly.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Expired (Generic available)
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of Triamcinolone Acetonide in various inflammatory and autoimmune conditions since its introduction.
Lab Monitoring
- Blood pressure
- Blood glucose
- Electrolytes (especially potassium)
- Bone mineral density (long-term use)
- Ophthalmic exams (long-term use)
Doctor Notes
- Assess for pre-existing conditions like diabetes, hypertension, and osteoporosis before initiating therapy.
- Educate patients on potential side effects and the importance of not discontinuing abruptly.
- Regular monitoring of blood pressure, blood glucose, and bone density is recommended for long-term users.
Patient Guidelines
- Do not stop the injection abruptly without consulting your doctor.
- Report any unusual side effects or worsening of condition.
- Inform your doctor about all other medications you are taking.
- Avoid close contact with people who have infections (e.g., chickenpox, measles).
Missed Dose Advice
As this is an injection administered by a healthcare professional, contact your doctor for instructions if an appointment is missed.
Driving Precautions
This medicine may cause dizziness or visual disturbances in some individuals. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet, potentially low in sodium and high in potassium if advised.
- Regular exercise can help mitigate bone and muscle effects.
- Avoid alcohol and smoking.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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