Triphin
Generic Name
Triphin 250 mg Injection
Manufacturer
MediCorp Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| triphin 250 mg injection | ৳ 80.24 | N/A |
Description
Overview of the medicine
Triphin 250 mg Injection is a first-generation cephalosporin antibiotic used to treat a variety of bacterial infections. It works by preventing the growth of bacteria and is administered intravenously or intramuscularly.
Uses & Indications
Dosage
Adults
250 mg to 1 g every 6 to 8 hours, depending on the severity of infection. For surgical prophylaxis, 1 g 30-60 minutes prior to surgery, then 500 mg-1 g every 6-12 hours for 24 hours.
Elderly
Dosage adjustment may be necessary in elderly patients with impaired renal function. Monitor renal function.
Renal_impairment
Dosage must be adjusted based on creatinine clearance. For CrCl 35-54 mL/min, administer usual dose every 8 hours. For CrCl 11-34 mL/min, administer usual dose every 12 hours. For CrCl <10 mL/min, administer usual dose every 18-24 hours.
How to Take
For IV administration, reconstitute the powder with sterile water for injection and administer slowly over 3-5 minutes or as an intermittent infusion. For IM administration, reconstitute and inject deep into a large muscle mass.
Mechanism of Action
Triphin works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located on the bacterial cell membrane, which are essential for cell wall synthesis. This interference leads to structural defects in the bacterial cell wall and eventual cell lysis and death.
Pharmacokinetics
Onset
Rapid, typically within 15-30 minutes for IV, 30-60 minutes for IM.
Excretion
Primarily renal, via glomerular filtration and tubular secretion. Approximately 80-90% of a dose is excreted unchanged in the urine within 24 hours.
Half life
Approximately 1.8 hours.
Absorption
Rapidly absorbed after intramuscular administration, peak plasma concentrations reached within 1-2 hours. High bioavailability.
Metabolism
Minimally metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cephalosporins or any component of the formulation
- History of severe hypersensitivity reaction to penicillin
Drug Interactions
Probenecid
May decrease renal tubular secretion of Triphin, increasing its plasma concentration and duration of action.
Anticoagulants (e.g., Warfarin)
May enhance the anticoagulant effect, requiring close monitoring of INR.
Nephrotoxic drugs (e.g., Aminoglycosides, Loop diuretics)
Concurrent use may increase the risk of nephrotoxicity.
Storage
Store below 30°C in a dry place, protected from light. Keep out of reach of children. Reconstituted solution should be used immediately or stored at 2-8°C for up to 24 hours.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric distress, and diarrhea. In severe cases, neurotoxicity (seizures) may occur. Treatment is supportive; hemodialysis may be useful in severe cases of renal impairment.
Pregnancy & Lactation
Pregnancy Category B. Animal reproduction studies have shown no risk, but no adequate studies in pregnant women. Use only if clearly needed. Excreted in breast milk in low concentrations; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to cephalosporins or any component of the formulation
- History of severe hypersensitivity reaction to penicillin
Drug Interactions
Probenecid
May decrease renal tubular secretion of Triphin, increasing its plasma concentration and duration of action.
Anticoagulants (e.g., Warfarin)
May enhance the anticoagulant effect, requiring close monitoring of INR.
Nephrotoxic drugs (e.g., Aminoglycosides, Loop diuretics)
Concurrent use may increase the risk of nephrotoxicity.
Storage
Store below 30°C in a dry place, protected from light. Keep out of reach of children. Reconstituted solution should be used immediately or stored at 2-8°C for up to 24 hours.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric distress, and diarrhea. In severe cases, neurotoxicity (seizures) may occur. Treatment is supportive; hemodialysis may be useful in severe cases of renal impairment.
Pregnancy & Lactation
Pregnancy Category B. Animal reproduction studies have shown no risk, but no adequate studies in pregnant women. Use only if clearly needed. Excreted in breast milk in low concentrations; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture when stored as recommended.
Availability
Hospitals, pharmacies, clinics
Approval Status
Approved by DGDA
Patent Status
Patent expired
WHO Essential Medicine
YesClinical Trials
Extensively studied in clinical trials for its efficacy and safety in various bacterial infections and surgical prophylaxis, demonstrating broad-spectrum activity and good tolerability.
Lab Monitoring
- Renal function tests (e.g., serum creatinine, BUN) in patients with impaired renal function
- Complete blood count (CBC) during prolonged therapy
- Liver function tests (LFTs) if clinically indicated
Doctor Notes
- Ensure proper reconstitution technique for IV/IM administration.
- Monitor renal function in patients with pre-existing renal impairment.
- Be aware of potential cross-reactivity with penicillin allergies.
Patient Guidelines
- Complete the full course of treatment, even if symptoms improve.
- Report any severe or persistent side effects to your doctor.
- Inform your healthcare provider about all other medications you are taking.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness in some individuals; if affected, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hydration.
- Avoid alcohol during treatment if experiencing gastrointestinal upset.
- Follow a balanced diet.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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