Triphin
Generic Name
Triphin-500 mg Injection
Manufacturer
Global Pharma Inc.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| triphin 500 mg injection | ৳ 120.37 | N/A |
Description
Overview of the medicine
Triphin 500 mg Injection is a broad-spectrum antibiotic belonging to the cephalosporin class. It is used to treat a wide range of bacterial infections in various parts of the body.
Uses & Indications
Dosage
Adults
500 mg - 1 g intravenously (IV) or intramuscularly (IM) every 12-24 hours, depending on the severity of infection.
Elderly
No specific dose adjustment is typically required, but caution is advised in patients with significant renal impairment.
Renal_impairment
Dose adjustment may be necessary in severe renal impairment (CrCl < 30 mL/min). Consult physician for specific guidelines.
How to Take
Administer slowly by intravenous (IV) infusion over 30-60 minutes or by deep intramuscular (IM) injection. Reconstitute the powder with appropriate solvent (e.g., sterile water for injection, lidocaine solution for IM).
Mechanism of Action
Triphin acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located in the bacterial cell wall, which are essential for peptidoglycan synthesis, thereby leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
Within 30 minutes to 2 hours depending on administration route.
Excretion
Excreted mainly unchanged via the kidneys (glomerular filtration and tubular secretion) and also partially via biliary excretion.
Half life
Approximately 6-9 hours.
Absorption
Rapid and complete absorption after intramuscular (IM) administration, achieving peak plasma concentrations within 2-3 hours. Intravenous (IV) administration provides immediate systemic availability.
Metabolism
Minimal hepatic metabolism, primarily metabolized to inactive compounds.
Side Effects
Contraindications
- Hypersensitivity to cephalosporins, penicillin, or any component of the formulation
- Previous severe hypersensitivity reaction to any beta-lactam antibiotic
Drug Interactions
Probenecid
May increase and prolong Triphin plasma concentrations.
Loop Diuretics
May increase the risk of nephrotoxicity.
Aminoglycosides
Increased risk of nephrotoxicity when co-administered.
Oral Anticoagulants (e.g., Warfarin)
May enhance the anticoagulant effect, requiring close monitoring of INR.
Storage
Store below 30°C in a dry place, away from direct light. Do not freeze. Reconstituted solution should be used immediately.
Overdose
Symptoms of overdose may include convulsions, encephalopathy, and neuromuscular excitability. Treatment is symptomatic and supportive. Hemodialysis may be useful in reducing plasma concentrations.
Pregnancy & Lactation
Use in pregnancy only if clearly needed and the potential benefits outweigh the potential risks. Small amounts may be excreted in breast milk; caution is advised during breastfeeding. Consult your doctor.
Side Effects
Contraindications
- Hypersensitivity to cephalosporins, penicillin, or any component of the formulation
- Previous severe hypersensitivity reaction to any beta-lactam antibiotic
Drug Interactions
Probenecid
May increase and prolong Triphin plasma concentrations.
Loop Diuretics
May increase the risk of nephrotoxicity.
Aminoglycosides
Increased risk of nephrotoxicity when co-administered.
Oral Anticoagulants (e.g., Warfarin)
May enhance the anticoagulant effect, requiring close monitoring of INR.
Storage
Store below 30°C in a dry place, away from direct light. Do not freeze. Reconstituted solution should be used immediately.
Overdose
Symptoms of overdose may include convulsions, encephalopathy, and neuromuscular excitability. Treatment is symptomatic and supportive. Hemodialysis may be useful in reducing plasma concentrations.
Pregnancy & Lactation
Use in pregnancy only if clearly needed and the potential benefits outweigh the potential risks. Small amounts may be excreted in breast milk; caution is advised during breastfeeding. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture when stored as recommended.
Availability
Hospitals, Clinics, Pharmacies
Approval Status
Approved by DGDA
Patent Status
Patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Triphin 500 mg Injection in treating various bacterial infections in adults and pediatric patients.
Lab Monitoring
- Monitor renal function (creatinine, BUN) in patients with pre-existing renal impairment or during prolonged therapy.
- Monitor liver function tests (ALT, AST) periodically.
- Complete blood count (CBC) should be monitored for signs of hematopoietic abnormalities.
Doctor Notes
- Before administration, carefully check for any history of hypersensitivity to beta-lactam antibiotics.
- Monitor patients for signs of superinfection, especially during prolonged therapy.
- Advise patients to report any unusual bleeding or bruising, especially if on anticoagulants.
Patient Guidelines
- Complete the full course of antibiotic treatment, even if you start to feel better.
- Do not save leftover medication for future infections.
- Report any severe or persistent side effects to your doctor immediately.
- Do not share this medicine with others.
Missed Dose Advice
If a dose is missed, administer it as soon as possible. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Triphin generally does not impair the ability to drive or operate machinery. However, if you experience dizziness or seizures, avoid these activities.
Lifestyle Advice
- Maintain good hydration throughout the course of treatment.
- Avoid alcohol consumption during antibiotic therapy as it may worsen side effects or reduce efficacy.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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