Vecef
Generic Name
Cefixime
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
vecef 125 mg pediatric drop | ৳ 50.00 | N/A |
Description
Overview of the medicine
Vecef-125 mg Pediatric Drop contains Cefixime, a third-generation cephalosporin antibiotic used to treat various bacterial infections in children.
Uses & Indications
Dosage
Adults
Not applicable for pediatric drops. For children: 8 mg/kg/day once daily or in two divided doses. Duration typically 5-14 days depending on infection.
Elderly
Not applicable for pediatric drops.
Renal_impairment
Dosage adjustment is necessary in patients with severe renal impairment (creatinine clearance < 30 ml/min).
How to Take
Administer orally, with or without food. Shake the bottle well before each use. Use the provided measuring dropper for accurate dosing. Complete the full course of medication.
Mechanism of Action
Cefixime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved 2-6 hours after administration.
Excretion
Mainly via urine (approximately 50% unchanged drug) and bile.
Half life
Approximately 3-4 hours.
Absorption
Approximately 40-50% orally absorbed. Food may delay absorption but does not significantly affect the extent.
Metabolism
Limited hepatic metabolism; primarily excreted as unchanged drug.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reactions (e.g., anaphylaxis) to penicillin or other beta-lactam antibiotics.
Drug Interactions
Probenecid
Increases cefixime plasma concentrations by decreasing renal excretion.
Carbamazepine
May increase carbamazepine plasma concentrations; monitoring is recommended.
Oral Anticoagulants (e.g., Warfarin)
May increase the anticoagulant effect, leading to increased bleeding risk. Monitor INR.
Storage
Store dry powder below 30°C, protected from light and moisture. After reconstitution, store in a refrigerator (2-8°C) and do not freeze. Discard after 7-14 days.
Overdose
In case of overdose, gastric lavage may be considered. There is no specific antidote; treatment should be supportive and symptomatic. Hemodialysis or peritoneal dialysis does not remove cefixime effectively.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use with caution in pregnant women if clearly needed. Small amounts of cefixime are excreted in breast milk; use with caution in breastfeeding mothers.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reactions (e.g., anaphylaxis) to penicillin or other beta-lactam antibiotics.
Drug Interactions
Probenecid
Increases cefixime plasma concentrations by decreasing renal excretion.
Carbamazepine
May increase carbamazepine plasma concentrations; monitoring is recommended.
Oral Anticoagulants (e.g., Warfarin)
May increase the anticoagulant effect, leading to increased bleeding risk. Monitor INR.
Storage
Store dry powder below 30°C, protected from light and moisture. After reconstitution, store in a refrigerator (2-8°C) and do not freeze. Discard after 7-14 days.
Overdose
In case of overdose, gastric lavage may be considered. There is no specific antidote; treatment should be supportive and symptomatic. Hemodialysis or peritoneal dialysis does not remove cefixime effectively.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use with caution in pregnant women if clearly needed. Small amounts of cefixime are excreted in breast milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years for unopened dry powder. 7-14 days for reconstituted suspension when stored appropriately.
Availability
Pharmacies, hospitals
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials in pediatric populations, establishing its efficacy and safety for various bacterial infections common in children. Post-marketing surveillance continues to monitor its long-term effects.
Lab Monitoring
- Renal function (for prolonged therapy or in patients with existing renal impairment)
- Complete Blood Count (CBC) and liver function tests (for prolonged therapy)
Doctor Notes
- Educate parents/caregivers on proper reconstitution, measurement, and administration techniques for pediatric drops.
- Emphasize the importance of completing the entire course of antibiotics to prevent bacterial resistance and recurrence of infection.
- Advise monitoring for signs of superinfection (e.g., oral thrush, new onset diarrhea) and allergic reactions.
Patient Guidelines
- Administer the medication for the entire prescribed duration, even if symptoms improve.
- Shake the bottle well before each use to ensure even distribution of the medicine.
- Use the specially marked dropper provided with the pack for accurate measurement of the dose.
- Store the reconstituted suspension as directed and discard any unused portion after the recommended period.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Cefixime generally does not impair the ability to drive or operate machinery. However, patients experiencing dizziness should exercise caution.
Lifestyle Advice
- Ensure proper hydration by drinking plenty of fluids.
- Maintain good hygiene to prevent spread or recurrence of infection.
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