Vecef
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vecef 125 mg suspension | ৳ 80.00 | N/A |
Description
Overview of the medicine
Cefixime is an oral third-generation cephalosporin antibiotic used to treat various bacterial infections. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
Not typically prescribed as a suspension for adults. If used, generally 200-400 mg daily in single or two divided doses.
Children
For children 6 months to 12 years: 8 mg/kg/day, given as a single daily dose or in two divided doses (4 mg/kg every 12 hours). Max dose: 400 mg/day.
Renal_impairment
Dose adjustment is required for patients with creatinine clearance < 60 mL/min. For CrCl 21-60 mL/min, 75% of standard dose. For CrCl < 20 mL/min, 50% of standard dose.
How to Take
Administer orally with or without food. Shake the bottle well before each use. Use the provided measuring device to ensure accurate dosing.
Mechanism of Action
Cefixime works by inhibiting bacterial cell wall synthesis, leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved within 2-6 hours after oral administration.
Excretion
Primarily excreted by the kidneys (20-50% as unchanged drug) and also through bile.
Half life
The plasma half-life is typically 3-4 hours.
Absorption
About 40-50% orally absorbed. Food slightly delays absorption but does not significantly affect efficacy.
Metabolism
Cefixime is not extensively metabolized; about 10% is metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reactions (e.g., anaphylaxis) to penicillin.
Drug Interactions
Probenecid
Increases cefixime plasma concentrations and prolongs its half-life by decreasing renal tubular secretion.
Carbamazepine
Elevated carbamazepine levels have been reported with concomitant cefixime administration.
Warfarin and other anticoagulants
May increase prothrombin time (PT) and International Normalized Ratio (INR), increasing the risk of bleeding.
Storage
Store the dry powder below 30°C in a dry place, away from direct sunlight. After reconstitution, store the suspension in a refrigerator (2-8°C) and discard any unused portion after 7-14 days (check specific product leaflet). Do not freeze.
Overdose
In case of overdose, gastric lavage may be indicated. There is no specific antidote. Hemodialysis and peritoneal dialysis are not effective in removing cefixime from the body.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown a risk, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Cefixime is excreted in low concentrations in human breast milk; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reactions (e.g., anaphylaxis) to penicillin.
Drug Interactions
Probenecid
Increases cefixime plasma concentrations and prolongs its half-life by decreasing renal tubular secretion.
Carbamazepine
Elevated carbamazepine levels have been reported with concomitant cefixime administration.
Warfarin and other anticoagulants
May increase prothrombin time (PT) and International Normalized Ratio (INR), increasing the risk of bleeding.
Storage
Store the dry powder below 30°C in a dry place, away from direct sunlight. After reconstitution, store the suspension in a refrigerator (2-8°C) and discard any unused portion after 7-14 days (check specific product leaflet). Do not freeze.
Overdose
In case of overdose, gastric lavage may be indicated. There is no specific antidote. Hemodialysis and peritoneal dialysis are not effective in removing cefixime from the body.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown a risk, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Cefixime is excreted in low concentrations in human breast milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Dry powder: Typically 24-36 months. Reconstituted suspension: 7-14 days when stored in a refrigerator.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety in treating a wide range of bacterial infections in both adult and pediatric populations.
Lab Monitoring
- Monitor renal function (creatinine, BUN) for prolonged therapy or in patients with pre-existing renal impairment.
- Monitor complete blood count (CBC) during prolonged therapy.
- Monitor PT/INR in patients concurrently taking anticoagulants.
Doctor Notes
- Advise patients to complete the full course of therapy to prevent resistance.
- Counsel patients on proper reconstitution and storage of the suspension.
- Monitor for signs of C. difficile-associated diarrhea, especially with prolonged use.
Patient Guidelines
- Complete the entire prescribed course of medication, even if symptoms improve, to prevent the development of antibiotic resistance.
- Shake the suspension well before each use.
- Do not save unused medication for future infections.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
Cefixime may cause dizziness or lightheadedness in some individuals. Patients should be cautioned about operating machinery or driving until they know how this medication affects them.
Lifestyle Advice
- Maintain good hygiene practices to prevent recurrent infections. Stay hydrated.
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