Vecef
Generic Name
Cefuroxime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vecef 500 mg injection | ৳ 50.00 | N/A |
Description
Overview of the medicine
Cefuroxime is a broad-spectrum second-generation cephalosporin antibiotic used to treat various bacterial infections. It works by inhibiting bacterial cell wall synthesis.
Uses & Indications
Dosage
Adults
750 mg to 1.5 g intravenously or intramuscularly every 8 hours, depending on infection severity.
Elderly
Same as adults, but may require dose adjustment based on renal function.
Renal_impairment
Dose adjustment required based on creatinine clearance; e.g., 750 mg every 12-24 hours for severe impairment.
How to Take
Administer intravenously (slow injection over 3-5 minutes or infusion over 30-60 minutes) or intramuscularly (deep into a large muscle mass like gluteal or lateral thigh).
Mechanism of Action
Cefuroxime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bactericidal action.
Pharmacokinetics
Onset
Rapid, typically within 15-30 minutes for therapeutic levels.
Excretion
Primarily via renal excretion by glomerular filtration and tubular secretion.
Half life
Approximately 1.2 to 1.6 hours.
Absorption
Rapidly absorbed after intramuscular administration, peak plasma concentrations reached within 30-60 minutes.
Metabolism
Not significantly metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cephalosporin antibiotics
- History of severe hypersensitivity to penicillin antibiotics
Drug Interactions
Probenecid
Increases cefuroxime plasma levels and prolongs its duration of action.
Aminoglycosides
Increased risk of nephrotoxicity.
Oral anticoagulants
May enhance anticoagulant effect; monitor INR.
Diuretics (e.g., Furosemide)
May increase risk of nephrotoxicity with high doses of cephalosporins.
Storage
Store below 25°C, protect from light and moisture. Reconstituted solution should be used immediately or stored for a short period as directed.
Overdose
Symptoms may include cerebral irritation leading to convulsions. Management includes supportive care and hemodialysis if severe.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy if clearly needed. Excreted in breast milk in small amounts; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to cephalosporin antibiotics
- History of severe hypersensitivity to penicillin antibiotics
Drug Interactions
Probenecid
Increases cefuroxime plasma levels and prolongs its duration of action.
Aminoglycosides
Increased risk of nephrotoxicity.
Oral anticoagulants
May enhance anticoagulant effect; monitor INR.
Diuretics (e.g., Furosemide)
May increase risk of nephrotoxicity with high doses of cephalosporins.
Storage
Store below 25°C, protect from light and moisture. Reconstituted solution should be used immediately or stored for a short period as directed.
Overdose
Symptoms may include cerebral irritation leading to convulsions. Management includes supportive care and hemodialysis if severe.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy if clearly needed. Excreted in breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, depending on manufacturer and storage conditions.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of cefuroxime in various bacterial infections.
Lab Monitoring
- Renal function tests (for prolonged therapy or renal impairment)
- Complete blood count (for prolonged therapy)
- Liver function tests (if clinically indicated)
Doctor Notes
- Ensure patient history of allergies, especially to penicillin and cephalosporins.
- Adjust dose in renal impairment.
- Monitor for signs of superinfection.
Patient Guidelines
- Complete the full course of treatment even if symptoms improve.
- Report any severe side effects immediately to your doctor.
- Do not share this medicine with others.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. If it is close to the time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Generally considered safe, but if dizziness occurs, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Stay hydrated.
- Avoid alcohol during treatment (though not a direct interaction, good general advice for infections).
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