Vertex
Generic Name
Cefepime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vertex 2 gm injection | ৳ 302.04 | N/A |
Description
Overview of the medicine
Cefepime is a broad-spectrum, fourth-generation cephalosporin antibiotic used to treat a wide variety of bacterial infections.
Uses & Indications
Dosage
Adults
1-2 gm IV/IM every 8-12 hours, depending on the severity and type of infection. Max dose 2 gm every 8 hours.
Elderly
Dosage adjustment may be necessary based on renal function, often starting with lower doses.
Renal_impairment
Reduced dosage is required based on creatinine clearance; dosage intervals may be extended.
How to Take
Vertex 2 gm Injection is administered intravenously (IV) over 30 minutes or intramuscularly (IM) into a large muscle mass. The powder should be reconstituted with an appropriate sterile solvent.
Mechanism of Action
Cefepime works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), leading to the disruption of bacterial cell wall formation and ultimately cell lysis.
Pharmacokinetics
Onset
Rapid (within minutes for IV administration).
Excretion
Primarily via the kidneys through glomerular filtration and tubular secretion.
Half life
Approximately 2 hours in individuals with normal renal function.
Absorption
Rapidly and completely absorbed after intramuscular (IM) or intravenous (IV) administration. Peak plasma concentrations are achieved shortly after IV infusion.
Metabolism
Minimal hepatic metabolism; about 85% is excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to cefepime, other cephalosporin antibiotics, penicillins, or any other beta-lactam antibiotics.
- History of severe hypersensitivity reactions to any component of this medication.
Drug Interactions
Metronidazole
No significant pharmacokinetic interaction, but should be administered separately due to physical incompatibility.
Aminoglycosides
Increased risk of nephrotoxicity and ototoxicity when administered concurrently.
Loop diuretics (e.g., Furosemide)
May increase the risk of nephrotoxicity with concomitant use.
Warfarin and other anticoagulants
May enhance the anticoagulant effect; close monitoring of INR (International Normalized Ratio) is advised.
Storage
Store the dry powder vials at controlled room temperature (below 30°C) and protect from light. Reconstituted solution is stable for 24 hours at room temperature or 7 days under refrigeration (2-8°C).
Overdose
Symptoms of overdose may include encephalopathy, seizures, myoclonus, and neuromuscular excitability. Management includes supportive care and, in severe cases, hemodialysis to remove the drug from the body.
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy only if clearly needed. Cefepime is excreted in breast milk in small amounts; caution should be exercised when administered to nursing mothers.
Side Effects
Contraindications
- Known hypersensitivity to cefepime, other cephalosporin antibiotics, penicillins, or any other beta-lactam antibiotics.
- History of severe hypersensitivity reactions to any component of this medication.
Drug Interactions
Metronidazole
No significant pharmacokinetic interaction, but should be administered separately due to physical incompatibility.
Aminoglycosides
Increased risk of nephrotoxicity and ototoxicity when administered concurrently.
Loop diuretics (e.g., Furosemide)
May increase the risk of nephrotoxicity with concomitant use.
Warfarin and other anticoagulants
May enhance the anticoagulant effect; close monitoring of INR (International Normalized Ratio) is advised.
Storage
Store the dry powder vials at controlled room temperature (below 30°C) and protect from light. Reconstituted solution is stable for 24 hours at room temperature or 7 days under refrigeration (2-8°C).
Overdose
Symptoms of overdose may include encephalopathy, seizures, myoclonus, and neuromuscular excitability. Management includes supportive care and, in severe cases, hemodialysis to remove the drug from the body.
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy only if clearly needed. Cefepime is excreted in breast milk in small amounts; caution should be exercised when administered to nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture. Refer to the product packaging for the exact expiry date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Cefepime has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections, including phase III trials that led to its approval for a broad range of indications.
Lab Monitoring
- Renal function tests (serum creatinine, BUN) should be monitored, especially in patients with pre-existing renal impairment.
- Complete blood count (CBC) should be monitored during prolonged therapy.
- Liver function tests (LFTs) periodically.
Doctor Notes
- Carefully assess renal function before initiating cefepime, and adjust dosage accordingly for renally impaired or elderly patients.
- Monitor for signs of neurotoxicity (e.g., encephalopathy, seizures), particularly in patients with renal dysfunction or those receiving high doses.
- Confirm bacterial susceptibility to cefepime whenever possible.
Patient Guidelines
- Report any signs of allergic reaction (e.g., rash, itching, swelling, difficulty breathing) immediately to your doctor or nurse.
- Complete the full prescribed course of treatment, even if symptoms improve, to prevent recurrence and antibiotic resistance.
- Inform your healthcare provider about all medications, supplements, and herbal products you are currently taking.
Missed Dose Advice
If a dose is missed, it should be administered as soon as remembered. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Cefepime may cause dizziness, confusion, or seizures in some patients. Patients should be cautioned about operating machinery or driving until they know how the medication affects them.
Lifestyle Advice
- Maintain good hydration throughout the treatment period.
- Avoid alcohol consumption during antibiotic treatment, as it may exacerbate side effects or reduce effectiveness.
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