Vertex
Generic Name
Cefuroxime Sodium 500 mg Injection
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vertex 500 mg injection | ৳ 130.39 | N/A |
Description
Overview of the medicine
Vertex 500 mg Injection contains Cefuroxime Sodium, a second-generation cephalosporin antibiotic used to treat a wide range of bacterial infections. It is effective against various Gram-positive and Gram-negative bacteria.
Uses & Indications
Dosage
Adults
Usually 750 mg every 8 hours by IM or IV injection. For severe infections, 1.5 g every 8 hours. For surgical prophylaxis, 1.5 g IV at induction, followed by 750 mg IM/IV every 8 hours for up to 24-48 hours.
Elderly
No specific dosage adjustment based solely on age is necessary, but renal function should be assessed and dosage adjusted if impaired.
Renal_impairment
Dosage interval should be extended based on creatinine clearance (e.g., every 12-24 hours for moderate impairment, every 48 hours for severe impairment).
How to Take
Vertex 500 mg Injection should be administered by a healthcare professional, either as a slow intravenous (IV) injection over 3-5 minutes or as an intramuscular (IM) injection deep into a large muscle mass. For IV infusion, it can be diluted and administered over 20-60 minutes. The reconstituted solution should be used immediately.
Mechanism of Action
Cefuroxime, like other beta-lactam antibiotics, inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). This leads to the disruption of bacterial cell wall formation and ultimately cell lysis and death.
Pharmacokinetics
Onset
Within minutes after IV administration; typically within 30-60 minutes after IM administration.
Excretion
Primarily excreted unchanged by the kidneys, through glomerular filtration and tubular secretion.
Half life
Approximately 1.2 to 1.6 hours in adults with normal renal function.
Absorption
Rapidly and completely absorbed after intramuscular (IM) administration; immediate and complete bioavailability after intravenous (IV) administration.
Metabolism
Not extensively metabolized in the body. Cefuroxime is excreted largely unchanged.
Side Effects
Contraindications
- Hypersensitivity to cefuroxime, any other cephalosporin antibiotics, or any component of the formulation.
- History of severe hypersensitivity (e.g., anaphylaxis) to any other type of beta-lactam antibacterial agent (e.g., penicillins, carbapenems).
Drug Interactions
Probenecid
Increases plasma concentrations and prolongs the half-life of cefuroxime.
Aminoglycosides
May increase the risk of nephrotoxicity.
Oral Anticoagulants
May enhance the anticoagulant effect.
Storage
Store the powder for injection below 30°C, protected from light and moisture. Do not freeze. Store reconstituted solution as per manufacturer guidelines, usually for a short period at room temperature or refrigerated.
Overdose
Symptoms of overdose may include convulsions, encephalopathy, and other neurological effects. Treatment is supportive and symptomatic. Hemodialysis or peritoneal dialysis may aid in the removal of cefuroxime from the body.
Pregnancy & Lactation
Pregnancy Category B. Cefuroxime crosses the placenta but has not shown harm in animal studies. Use during pregnancy only if clearly needed. Excreted in breast milk in small amounts; generally considered compatible with breastfeeding, but caution is advised.
Side Effects
Contraindications
- Hypersensitivity to cefuroxime, any other cephalosporin antibiotics, or any component of the formulation.
- History of severe hypersensitivity (e.g., anaphylaxis) to any other type of beta-lactam antibacterial agent (e.g., penicillins, carbapenems).
Drug Interactions
Probenecid
Increases plasma concentrations and prolongs the half-life of cefuroxime.
Aminoglycosides
May increase the risk of nephrotoxicity.
Oral Anticoagulants
May enhance the anticoagulant effect.
Storage
Store the powder for injection below 30°C, protected from light and moisture. Do not freeze. Store reconstituted solution as per manufacturer guidelines, usually for a short period at room temperature or refrigerated.
Overdose
Symptoms of overdose may include convulsions, encephalopathy, and other neurological effects. Treatment is supportive and symptomatic. Hemodialysis or peritoneal dialysis may aid in the removal of cefuroxime from the body.
Pregnancy & Lactation
Pregnancy Category B. Cefuroxime crosses the placenta but has not shown harm in animal studies. Use during pregnancy only if clearly needed. Excreted in breast milk in small amounts; generally considered compatible with breastfeeding, but caution is advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years when stored unopened. Reconstituted solution should be used immediately or within a specific timeframe as per manufacturer's instructions.
Availability
Pharmacies, Hospitals, Clinics
Approval Status
Approved by major regulatory authorities worldwide
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Cefuroxime has been extensively studied in numerous clinical trials demonstrating its efficacy and safety in various bacterial infections. Post-marketing surveillance continues to monitor its long-term effects.
Lab Monitoring
- Renal function tests (creatinine, BUN) for patients with pre-existing renal impairment or prolonged high-dose therapy.
- Complete Blood Count (CBC) for prolonged therapy to monitor for hematologic abnormalities.
Doctor Notes
- Always confirm bacterial susceptibility before initiating therapy.
- Adjust dosage in patients with renal impairment.
- Be aware of potential cross-reactivity in patients with penicillin allergy.
Patient Guidelines
- Complete the entire course of medication as prescribed, even if symptoms improve.
- Report any unusual or severe side effects to your doctor immediately.
- Inform your doctor about any allergies, especially to penicillins or other antibiotics.
Missed Dose Advice
If a dose is missed, it should be administered as soon as remembered, unless it is almost time for the next scheduled dose. In such cases, the missed dose should be skipped, and the regular dosing schedule should be resumed. Do not double the dose.
Driving Precautions
Generally, Cefuroxime does not impair the ability to drive or operate machinery. However, if side effects like dizziness occur, patients should avoid such activities.
Lifestyle Advice
- Maintain good hydration during treatment.
- Get adequate rest to support recovery.
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