Xalcort
Generic Name
Deflazacort
Manufacturer
Eskayef Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| xalcort 24 mg tablet | ৳ 30.00 | ৳ 300.00 |
Description
Overview of the medicine
Deflazacort is a corticosteroid used to treat various inflammatory conditions, autoimmune diseases, and specifically Duchenne muscular dystrophy.
Uses & Indications
Dosage
Adults
Varies widely based on condition. For Duchenne Muscular Dystrophy, typically 0.9 mg/kg/day. For other inflammatory conditions, initial doses might range from 6-90 mg/day, gradually tapered.
Elderly
Caution advised; lower doses may be considered due to increased sensitivity and risk of adverse effects.
Renal_impairment
No specific dose adjustment usually needed, but monitor patients closely.
How to Take
Take orally, once daily, preferably with food to minimize gastrointestinal upset. Swallow the tablet whole with water. Do not stop abruptly.
Mechanism of Action
Deflazacort is a glucocorticoid with anti-inflammatory and immunosuppressive properties. It acts by binding to glucocorticoid receptors, modifying gene expression to reduce inflammation and suppress immune responses.
Pharmacokinetics
Onset
Varies by condition, generally within hours for initial effects.
Excretion
Primarily through urine (approximately 60%) and feces (approximately 30%).
Half life
Active metabolite (21-desacetyl deflazacort) has a half-life of 1.1-2.7 hours.
Absorption
Well absorbed orally. Peak plasma concentration of active metabolite reached in approximately 1.5-2 hours.
Metabolism
Rapidly metabolized in the liver to its active metabolite 21-desacetyl deflazacort.
Side Effects
Contraindications
- •Systemic fungal infections
- •Hypersensitivity to deflazacort or any component of the tablet
Drug Interactions
Ketoconazole, Erythromycin
These drugs can increase deflazacort plasma concentrations, potentially enhancing its side effects.
Phenobarbital, Phenytoin, Rifampicin
These drugs can decrease deflazacort plasma concentrations, potentially reducing its effectiveness.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include exaggerated side effects such as increased blood pressure, fluid retention, hyperglycemia, and Cushingoid features. Management is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy or lactation only if the potential benefit justifies the potential risk to the fetus or infant. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved in major markets
Patent Status
Off-patent (for generic molecule)
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Global Brand Names
International brand names for this medicine
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