Zedoxim
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zedoxim 200 mg capsule | ৳ 40.00 | ৳ 160.00 |
Description
Overview of the medicine
Cefixime is an oral third-generation cephalosporin antibiotic used to treat a variety of bacterial infections, including those of the respiratory tract, urinary tract, and ear, nose, and throat.
Uses & Indications
Dosage
Adults
Adults and children over 10 years or weighing more than 50 kg: 200 mg once daily or 100 mg twice daily. For severe infections or uncomplicated gonorrhea, dose may be increased to 400 mg once daily.
Elderly
No dosage adjustment needed for elderly patients with normal renal function.
Renal_impairment
Creatinine clearance 21-60 mL/min: 75% of standard dose. Creatinine clearance <20 mL/min: 50% of standard dose.
How to Take
Cefixime capsules can be taken with or without food. To minimize gastrointestinal upset, it is often recommended to take with food.
Mechanism of Action
Cefixime exerts its bactericidal effect by interfering with the synthesis of the bacterial cell wall. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby inhibiting the third and final stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved within 2-6 hours after administration.
Excretion
Approximately 50-60% excreted unchanged in urine over 24 hours, about 10% via bile.
Half life
Approximately 3-4 hours.
Absorption
Approximately 40-50% absorbed from the gastrointestinal tract, food delays absorption but does not significantly affect overall absorption.
Metabolism
Not extensively metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or other cephalosporins
- History of anaphylactic reaction to penicillin
Drug Interactions
Warfarin
May increase prothrombin time (INR), requiring careful monitoring.
Probenecid
Increases cefixime plasma concentrations by inhibiting renal excretion.
Carbamazepine
Increased carbamazepine levels when co-administered.
Oral Contraceptives
May reduce the efficacy of oral contraceptives; advise using alternative birth control methods.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Gastric lavage may be indicated. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Management should be supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or other cephalosporins
- History of anaphylactic reaction to penicillin
Drug Interactions
Warfarin
May increase prothrombin time (INR), requiring careful monitoring.
Probenecid
Increases cefixime plasma concentrations by inhibiting renal excretion.
Carbamazepine
Increased carbamazepine levels when co-administered.
Oral Contraceptives
May reduce the efficacy of oral contraceptives; advise using alternative birth control methods.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Gastric lavage may be indicated. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Management should be supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by drug regulatory authorities (e.g., DGDA, FDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established cefixime's efficacy and safety for various bacterial infections, confirming its role as a broad-spectrum oral antibiotic.
Lab Monitoring
- Renal function tests (for prolonged therapy or renal impairment)
- Complete blood count (CBC) for prolonged therapy
- Liver function tests (LFTs) if clinically indicated
- Prothrombin time (PT/INR) if co-administered with anticoagulants
Doctor Notes
- Consider patient's history of hypersensitivity to penicillin and cephalosporins.
- Monitor renal function in patients with pre-existing renal impairment.
- Advise patients on the importance of completing the full course of therapy.
Patient Guidelines
- Take the full course of medicine even if symptoms improve.
- Do not share this medicine with others.
- Inform your doctor if you experience severe diarrhea.
- Avoid alcohol consumption during treatment.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Cefixime may cause dizziness in some individuals. Patients should be advised to exercise caution before driving or operating machinery if they experience such effects.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Drink plenty of fluids to stay hydrated.
- Eat a balanced diet.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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