Zedoxim
Generic Name
Cefpodoxime Proxetil
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
zedoxim 40 mg suspension | ৳ 95.00 | N/A |
Description
Overview of the medicine
Zedoxim 40 mg Suspension contains Cefpodoxime Proxetil, a third-generation cephalosporin antibiotic, used to treat a wide range of bacterial infections in children.
Uses & Indications
Dosage
Adults
Not typically used for adults in suspension form; adult dosage for tablets varies.
Elderly
Not typically used for elderly in suspension form; elderly dosage for tablets varies, often with renal adjustment.
Renal_impairment
Dosage adjustment required for patients with creatinine clearance <30 mL/min.
How to Take
Shake the bottle well before each use. Administer orally with food to enhance absorption and reduce gastrointestinal upset. Use the provided measuring device for accurate dosing.
Mechanism of Action
Cefpodoxime Proxetil is a prodrug that is de-esterified in the gastrointestinal tract to its active metabolite, cefpodoxime. Cefpodoxime exerts its bactericidal action by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the cross-linking of peptidoglycan polymers, ultimately leading to cell lysis and death.
Pharmacokinetics
Onset
Typically within 1-3 hours.
Excretion
Mainly excreted unchanged in the urine, approximately 29-33% of the administered dose.
Half life
Approximately 2.0-3.0 hours.
Absorption
Cefpodoxime proxetil is absorbed from the gastrointestinal tract and de-esterified to cefpodoxime. Oral bioavailability is approximately 50% following administration with food.
Metabolism
Primarily de-esterified in the gastrointestinal tract to active cefpodoxime. Minimal metabolism of active cefpodoxime occurs.
Side Effects
Contraindications
- Hypersensitivity to cefpodoxime or other cephalosporins
- History of severe hypersensitivity reactions to any other beta-lactam antibiotic (e.g., penicillins)
Drug Interactions
Probenecid
Can increase cefpodoxime plasma levels by decreasing renal excretion.
Antacids/H2 Blockers
Can decrease cefpodoxime absorption (e.g., antacids, ranitidine, cimetidine). Administer cefpodoxime 2-3 hours after antacids/H2 blockers.
Oral anticoagulants (e.g., Warfarin)
Increased INR/bleeding risk. Monitor coagulation parameters.
Storage
Store dry powder below 30°C, protected from light and moisture. After reconstitution, store in a refrigerator (2-8°C). Do not freeze.
Overdose
In case of overdose, symptomatic and supportive measures are recommended. Hemodialysis or peritoneal dialysis may be helpful in removing cefpodoxime from the body, especially in patients with impaired renal function.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Small amounts of cefpodoxime are excreted in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to cefpodoxime or other cephalosporins
- History of severe hypersensitivity reactions to any other beta-lactam antibiotic (e.g., penicillins)
Drug Interactions
Probenecid
Can increase cefpodoxime plasma levels by decreasing renal excretion.
Antacids/H2 Blockers
Can decrease cefpodoxime absorption (e.g., antacids, ranitidine, cimetidine). Administer cefpodoxime 2-3 hours after antacids/H2 blockers.
Oral anticoagulants (e.g., Warfarin)
Increased INR/bleeding risk. Monitor coagulation parameters.
Storage
Store dry powder below 30°C, protected from light and moisture. After reconstitution, store in a refrigerator (2-8°C). Do not freeze.
Overdose
In case of overdose, symptomatic and supportive measures are recommended. Hemodialysis or peritoneal dialysis may be helpful in removing cefpodoxime from the body, especially in patients with impaired renal function.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Small amounts of cefpodoxime are excreted in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months for dry powder. Reconstituted suspension stable for 14 days when refrigerated.
Availability
Available in pharmacies, hospitals, and clinics
Approval Status
Approved by health authorities like FDA/DGDA
Patent Status
Generic available, original patent expired
Clinical Trials
Extensive clinical trials have established the efficacy and safety of cefpodoxime in the treatment of various bacterial infections in pediatric and adult populations.
Lab Monitoring
- Renal function tests (e.g., creatinine, BUN) in patients with impaired renal function
- Complete Blood Count (CBC) if long-term treatment is planned
- Coagulation parameters if concomitant oral anticoagulants are used
Doctor Notes
- Prescribe the appropriate dose based on patient's weight and infection type.
- Advise parents/caregivers on the importance of completing the full course and accurate measurement.
- Monitor for signs of allergic reactions, especially in patients with penicillin allergy history.
Patient Guidelines
- Complete the full course of antibiotics, even if symptoms improve.
- Do not save medication for future use or share it with others.
- Shake the bottle well before each use and measure the dose accurately.
- Take with food to minimize stomach upset.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Zedoxim suspension is generally not expected to affect the ability to drive or operate machinery. However, if side effects like dizziness occur, patients should avoid such activities.
Lifestyle Advice
- Maintain good hygiene to prevent spread of infection.
- Ensure adequate fluid intake, especially if experiencing diarrhea.
- Avoid self-medication and consult a doctor for proper diagnosis and treatment.
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