Zerotil
Generic Name
Cefuroxime Axetil
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zerotil 250 mg tablet | ৳ 32.00 | ৳ 224.00 |
Description
Overview of the medicine
Zerotil 250 mg tablet contains Cefuroxime Axetil, a second-generation cephalosporin antibiotic used to treat a wide range of bacterial infections. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
Most infections: 250 mg twice daily. Severe infections or bronchitis/pneumonia: 500 mg twice daily. Gonorrhea: 1000 mg as a single dose.
Elderly
No special dosage recommendations for elderly patients with normal renal function.
Renal_impairment
Dosage adjustment may be necessary for patients with severe renal impairment (CrCl < 30 mL/min).
How to Take
Oral administration. Take with food for optimal absorption. Tablets should not be crushed.
Mechanism of Action
Cefuroxime Axetil is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). This leads to osmotic instability and lysis of bacterial cells.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved in approximately 2-3 hours after a meal.
Excretion
Primarily excreted unchanged by the kidneys via glomerular filtration and tubular secretion.
Half life
Approximately 1.2-1.6 hours.
Absorption
Well absorbed from the gastrointestinal tract after oral administration, with enhanced absorption when taken with food. Bioavailability is approximately 37% when taken without food and 52% when taken with food.
Metabolism
Cefuroxime axetil is rapidly hydrolyzed by esterases to cefuroxime in the intestinal mucosa and blood. It is not significantly metabolized further in the liver.
Side Effects
Contraindications
- Hypersensitivity to cefuroxime, any other cephalosporin, or any of the excipients.
- Previous immediate and/or severe hypersensitivity to penicillin or any other type of beta-lactam antibacterial agent.
Drug Interactions
Warfarin
Increased INR has been reported in patients taking cefuroxime and warfarin concurrently.
Probenecid
May increase cefuroxime levels due to decreased renal tubular secretion.
Oral contraceptives
May reduce the efficacy of oral contraceptives.
Antacids/H2-receptor antagonists
May reduce the bioavailability of cefuroxime axetil.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include cerebral irritation leading to convulsions. Management is supportive, including activated charcoal and gastric lavage if ingested recently. Hemodialysis can reduce serum levels.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by FDA/DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensively studied in various clinical trials demonstrating efficacy and safety for approved indications.
Lab Monitoring
- Liver function tests (LFTs) if prolonged use or pre-existing hepatic impairment
- Renal function tests (RFTs) if prolonged use or pre-existing renal impairment
- Complete blood count (CBC) if prolonged use
Doctor Notes
- Advise patients to complete the full course of therapy to prevent antibiotic resistance.
- Monitor for signs of allergic reactions, especially in patients with a history of penicillin allergy.
- Consider renal dose adjustment in patients with impaired kidney function.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Take with food to enhance absorption and reduce stomach upset.
- Report any severe diarrhea or allergic reactions immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
May cause dizziness; caution is advised when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain good hydration, avoid alcohol if it exacerbates gastrointestinal side effects.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.