Zerotil
Generic Name
Cefuroxime
Manufacturer
Generic Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zerotil 750 mg injection | ৳ 200.00 | N/A |
Description
Overview of the medicine
Cefuroxime is a second-generation cephalosporin antibiotic used to treat various bacterial infections including respiratory tract infections, urinary tract infections, and skin and soft tissue infections.
Uses & Indications
Dosage
Adults
750 mg IV/IM every 8 hours for most infections; 1.5 g IV every 8 hours for severe infections or meningitis. Surgical prophylaxis: 1.5 g IV/IM pre-surgery, followed by 750 mg every 8 hours for up to 24-48 hours.
Elderly
No specific dose adjustment needed unless severe renal impairment. Refer to renal impairment guidelines.
Renal_impairment
Dose reduction required based on creatinine clearance. For CrCl 10-20 mL/min: 750 mg every 12 hours. For CrCl <10 mL/min: 750 mg every 24 hours. Hemodialysis: 750 mg at the end of each dialysis session.
How to Take
Administer intravenously (slow injection over 3-5 minutes or infusion over 30-60 minutes) or intramuscularly (deep injection into a large muscle mass). The powder should be reconstituted with sterile water for injection according to manufacturer's instructions.
Mechanism of Action
Cefuroxime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Within 15-60 minutes after IV administration.
Excretion
Primarily excreted unchanged in the urine via glomerular filtration and tubular secretion.
Half life
Approximately 1-1.5 hours in adults with normal renal function.
Absorption
Rapidly absorbed after intramuscular (IM) or intravenous (IV) administration. Peak plasma concentrations are achieved shortly after administration.
Metabolism
Not significantly metabolized in the liver; it is excreted unchanged.
Side Effects
Contraindications
- •Known hypersensitivity to cephalosporin antibiotics
- •History of severe hypersensitivity (e.g., anaphylaxis) to any other type of beta-lactam antibacterial agent (e.g., penicillins, monobactams, carbapenems)
Drug Interactions
Probenecid
Increases cefuroxime plasma concentrations and prolongs its half-life by reducing renal tubular secretion.
Aminoglycosides
Concurrent use may increase the risk of nephrotoxicity. Monitor renal function closely.
Oral anticoagulants
May potentiate the anticoagulant effect. Close monitoring of INR is recommended.
Storage
Store the dry powder below 30°C in a dry place, protected from light. Reconstituted solution is stable for 24 hours when stored at 2-8°C (refrigerator) or for up to 5 hours at 25°C.
Overdose
Symptoms of overdose may include cerebral irritation leading to convulsions. Management is supportive, and hemodialysis may be considered in severe cases to remove cefuroxime from the body.
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy only if clearly needed after careful risk-benefit assessment. Cefuroxime is excreted in breast milk in small amounts; use with caution during lactation and monitor the infant for gastrointestinal disturbances (e.g., diarrhea) or fungal infections.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the manufacturing date, when stored under recommended conditions.
Availability
Hospitals, Clinics, Pharmacies
Approval Status
Approved
Patent Status
Generic Available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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