Medicine Information

Brodil

Name: Brodil
Brand: Brodil

Syrup2 mg/5 mLBronchodilatorATC: R03AC02

Generic Name

Salbutamol Sulfate

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
brodil 2 mg syrup	৳ 23.00	N/A

Description

Overview of the medicine

Brodil 2 mg Syrup contains Salbutamol, a fast-acting bronchodilator used to relieve symptoms of asthma and chronic obstructive pulmonary disease (COPD) such as wheezing, shortness of breath, and chest tightness.

Uses & Indications

Relief of bronchospasm in bronchial asthma

Chronic obstructive pulmonary disease (COPD)

Exercise-induced bronchospasm

Dosage

Adults

2-4 mg (1-2 teaspoonfuls) 3-4 times daily.

Elderly

Starting dose may be lower, e.g., 2 mg (1 teaspoonful) 3-4 times daily, adjusted according to response.

Renal_impairment

No specific dose adjustment required for mild to moderate renal impairment; use with caution in severe cases.

How to Take

Administer orally. Can be taken with or without food. Use a measuring spoon or cup for accurate dosing.

Mechanism of Action

Salbutamol selectively stimulates beta-2 adrenergic receptors in the smooth muscle of the bronchial tree, leading to bronchodilation. It also inhibits the release of mast cell mediators from the lungs.

Pharmacokinetics

Onset

Bronchodilation typically occurs within 5-15 minutes.

Excretion

Primarily excreted in the urine as metabolites and unchanged drug.

Half life

Plasma half-life is approximately 4-6 hours.

Absorption

Rapidly and well absorbed from the gastrointestinal tract after oral administration.

Metabolism

Extensively metabolized in the liver to inactive conjugates (e.g., salbutamol 4'-O-sulfate).

Side Effects

Contraindications

Hypersensitivity to Salbutamol or any component of the syrup
Concurrent use with non-selective beta-blockers
Severe heart conditions (use with extreme caution)

Drug Interactions

Diuretics

Potentially severe hypokalemia with concomitant use, especially with high doses.

Beta-blockers

Non-selective beta-blockers (e.g., Propranolol) may antagonize the effect of Salbutamol and can cause severe bronchospasm.

Monoamine Oxidase Inhibitors (MAOIs) & Tricyclic Antidepressants (TCAs)

Increased risk of cardiovascular effects; use with caution.

Storage

Store below 30°C. Protect from light and moisture. Keep out of reach of children. Do not freeze.

Overdose

Symptoms of overdose include tachycardia, tremors, headache, hyperglycemia, and hypokalemia. Treatment is symptomatic and supportive, including discontinuing the drug and monitoring potassium levels.

Pregnancy & Lactation

Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is secreted in breast milk; use with caution in nursing mothers.

Side Effects

Contraindications

Hypersensitivity to Salbutamol or any component of the syrup
Concurrent use with non-selective beta-blockers
Severe heart conditions (use with extreme caution)

Drug Interactions

Diuretics

Potentially severe hypokalemia with concomitant use, especially with high doses.

Beta-blockers

Non-selective beta-blockers (e.g., Propranolol) may antagonize the effect of Salbutamol and can cause severe bronchospasm.

Monoamine Oxidase Inhibitors (MAOIs) & Tricyclic Antidepressants (TCAs)

Increased risk of cardiovascular effects; use with caution.

Storage

Store below 30°C. Protect from light and moisture. Keep out of reach of children. Do not freeze.

Overdose

Symptoms of overdose include tachycardia, tremors, headache, hyperglycemia, and hypokalemia. Treatment is symptomatic and supportive, including discontinuing the drug and monitoring potassium levels.

Pregnancy & Lactation

Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is secreted in breast milk; use with caution in nursing mothers.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

100 mL bottle50 mL bottle

Shelf Life

Typically 24-36 months from the date of manufacture. Check the expiry date on the packaging.

Availability

Available in all pharmacies and drug stores

Approval Status

Approved by regulatory authorities worldwide, including DGDA (Bangladesh)

Patent Status

Generic available, original patent expired

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have established the efficacy and safety of Salbutamol in the management of bronchospastic conditions across various age groups.

Lab Monitoring

Monitor serum potassium levels, especially in patients receiving high doses or concomitant diuretics.
Monitor blood glucose in diabetic patients.

Doctor Notes

Advise patients on proper inhaler technique if also using an inhaler.
Caution against overuse, which can lead to adverse effects and mask worsening asthma.
Educate on distinguishing between reliever and controller medications.

Patient Guidelines

Follow your doctor's instructions carefully.
Do not exceed the recommended dose.
Shake the bottle well before each use.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Brodil Syrup usually does not affect the ability to drive or operate machinery. However, if you experience side effects like tremor or dizziness, avoid driving or operating heavy machinery.

Lifestyle Advice

Avoid triggers for asthma/COPD exacerbations (e.g., smoke, allergens).
Maintain a healthy lifestyle with regular exercise and a balanced diet (as tolerated).