Ciprozid
Generic Name
ciprozid-250-mg-tablet
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ciprozid 250 mg tablet | ৳ 8.50 | ৳ 85.00 |
Description
Overview of the medicine
Ciprozid 250 mg Tablet contains Ciprofloxacin, a fluoroquinolone antibiotic used to treat a wide range of bacterial infections. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
250-750 mg orally twice daily, depending on the type and severity of infection. For most UTIs, 250 mg twice daily for 3-7 days.
Elderly
Dosage adjustment may be necessary based on renal function.
Renal_impairment
CrCl 30-60 mL/min: 250-500 mg every 12 hours. CrCl <30 mL/min: 250-500 mg every 18-24 hours.
How to Take
Take orally with a glass of water, with or without food. Avoid taking with dairy products, calcium-fortified juices, or antacids containing magnesium/aluminum.
Mechanism of Action
Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Within 1-2 hours.
Excretion
Mainly via renal excretion (50-70% as unchanged drug) and some through fecal route.
Half life
Approximately 3-5 hours.
Absorption
Rapidly and well absorbed from the gastrointestinal tract; absolute bioavailability is approximately 70%.
Metabolism
Partially metabolized in the liver (15-30%) to less active metabolites.
Side Effects
Contraindications
- Hypersensitivity to ciprofloxacin or other fluoroquinolones
- Concomitant administration with tizanidine
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, requiring INR monitoring.
Tizanidine
Concomitant use is contraindicated due to increased tizanidine plasma concentrations, potentially leading to hypotension and sedation.
Theophylline
Increased plasma concentrations of theophylline, leading to increased risk of toxicity.
Antacids/Mineral supplements (containing Mg, Al, Ca, Fe, Zn)
Reduce absorption of ciprofloxacin. Administer ciprofloxacin 2 hours before or 6 hours after these agents.
Storage
Store at room temperature (below 30°C), protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include renal toxicity. Treatment is symptomatic and supportive; hemodialysis or peritoneal dialysis may be helpful.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Ciprofloxacin is excreted into breast milk; consider discontinuing nursing or the drug.
Side Effects
Contraindications
- Hypersensitivity to ciprofloxacin or other fluoroquinolones
- Concomitant administration with tizanidine
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, requiring INR monitoring.
Tizanidine
Concomitant use is contraindicated due to increased tizanidine plasma concentrations, potentially leading to hypotension and sedation.
Theophylline
Increased plasma concentrations of theophylline, leading to increased risk of toxicity.
Antacids/Mineral supplements (containing Mg, Al, Ca, Fe, Zn)
Reduce absorption of ciprofloxacin. Administer ciprofloxacin 2 hours before or 6 hours after these agents.
Storage
Store at room temperature (below 30°C), protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include renal toxicity. Treatment is symptomatic and supportive; hemodialysis or peritoneal dialysis may be helpful.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Ciprofloxacin is excreted into breast milk; consider discontinuing nursing or the drug.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous clinical trials demonstrating efficacy and safety for various bacterial infections.
Lab Monitoring
- Renal function tests (e.g., serum creatinine, BUN) in patients with impaired renal function
- Liver function tests (e.g., ALT, AST) if liver dysfunction is suspected
- INR for patients on warfarin
Doctor Notes
- Counsel patients on potential severe side effects like tendinitis/tendon rupture and peripheral neuropathy.
- Monitor renal function, especially in elderly or renally impaired patients.
- Advise patients to avoid concurrent use with dairy products, antacids, and mineral supplements.
Patient Guidelines
- Complete the full course of treatment even if symptoms improve.
- Stay well hydrated to prevent crystalluria.
- Avoid excessive sun exposure due to photosensitivity.
- Report any pain, swelling, or inflammation of tendons immediately.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances. Advise patients to use caution when driving or operating machinery until they know how the drug affects them.
Lifestyle Advice
- Maintain good hygiene to prevent infections.
- Consume a balanced diet.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Ciprozid Brand
Other medicines available under the same brand name
