D3
Generic Name
Cholecalciferol (Vitamin D3)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| d3 2000 iu tablet | ৳ 2.50 | ৳ 25.00 |
Description
Overview of the medicine
Cholecalciferol (Vitamin D3) is a fat-soluble vitamin essential for the absorption of calcium and phosphorus, crucial for maintaining strong bones, teeth, and supporting immune system function.
Uses & Indications
Dosage
Adults
Typically 2000-4000 IU daily for deficiency, or 800-2000 IU daily for maintenance, adjusted based on serum 25(OH)D levels.
Elderly
Similar to adults, but often higher doses are needed due to reduced skin synthesis and absorption. Consult a physician.
Renal_impairment
Use with caution. Active form (calcitriol) may be preferred in severe cases. Monitor calcium and phosphate levels closely.
How to Take
Oral administration. Tablets can be taken with or without food, but absorption is better with a fatty meal.
Mechanism of Action
Cholecalciferol is biologically inactive but is hydroxylated in the liver to 25-hydroxycholecalciferol (calcifediol) and then in the kidneys to 1,25-dihydroxycholecalciferol (calcitriol). Calcitriol is the active form that promotes calcium and phosphate absorption from the intestine, regulates bone metabolism, and supports immune function.
Pharmacokinetics
Onset
Several hours to days for significant changes in serum 25(OH)D levels.
Excretion
Mainly excreted in the bile and feces, with a small amount excreted in urine.
Half life
Approximately 15-20 days for 25-hydroxyvitamin D; calcitriol has a shorter half-life of 3-6 hours.
Absorption
Well absorbed from the gastrointestinal tract, especially in the presence of bile salts and dietary fat.
Metabolism
Primarily hydroxylated in the liver to 25-hydroxyvitamin D, then in the kidneys to 1,25-dihydroxyvitamin D (calcitriol) and other inactive metabolites.
Side Effects
Contraindications
- •Hypercalcemia
- •Hypervitaminosis D
- •Malabsorption syndrome (severe)
- •Severe renal osteodystrophy with hyperphosphatemia
Drug Interactions
Corticosteroids
May reduce vitamin D effects.
Thiazide diuretics
May increase the risk of hypercalcemia.
Bile acid sequestrants (e.g., Cholestyramine)
May impair vitamin D absorption.
Anticonvulsants (e.g., Phenytoin, Barbiturates)
May increase vitamin D metabolism, reducing its effectiveness.
Storage
Store below 30°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypercalcemia, hypercalciuria, nausea, vomiting, polyuria, thirst, and weakness. Severe cases can lead to renal impairment. Management involves discontinuing vitamin D, restricting dietary calcium, increasing fluid intake, and in severe cases, corticosteroids.
Pregnancy & Lactation
Generally considered safe at physiological doses during pregnancy and lactation. High doses should be avoided as they may be harmful. Consult a healthcare provider before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months
Availability
Pharmacies, drugstores, supermarkets
Approval Status
Approved
Patent Status
Generic
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in
