D3
Generic Name
Cholecalciferol (Vitamin D3) 400 IU Oral Solution
Manufacturer
Various manufacturers
Country
Global
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| d3 400 iu oral solution | ৳ 250.00 | N/A |
Description
Overview of the medicine
D3 400 IU Oral Solution contains Cholecalciferol, which is Vitamin D3. It is essential for the absorption of calcium and phosphorus, playing a crucial role in maintaining bone health, immune function, and overall well-being. This oral solution is commonly used to prevent and treat vitamin D deficiency, especially in infants, children, and individuals with limited sun exposure.
Uses & Indications
Dosage
Adults
For vitamin D deficiency, typically 400 IU to 1000 IU daily, but higher doses may be needed depending on deficiency severity and medical advice.
Elderly
Similar to adult dosage, but often higher doses (e.g., 800 IU daily) are recommended due to decreased skin synthesis and absorption.
Renal_impairment
Use with caution. Active vitamin D metabolites might be preferred in severe renal impairment. Consultation with a physician is essential.
How to Take
Administer orally. For infants and young children, use the provided dropper to measure the exact dose and mix with milk, juice, or food. For adults, it can be taken directly or mixed with a beverage.
Mechanism of Action
Cholecalciferol (Vitamin D3) is a precursor that is metabolized in the liver to 25-hydroxyvitamin D [25(OH)D] (calcifediol) and then in the kidneys to the active form, 1,25-dihydroxyvitamin D [1,25(OH)2D] (calcitriol). Calcitriol acts on vitamin D receptors (VDRs) in various tissues, primarily in the intestine, bone, and kidney, to regulate calcium and phosphate homeostasis. It promotes intestinal absorption of calcium and phosphate, stimulates bone mineralization, and influences parathyroid hormone secretion.
Pharmacokinetics
Onset
Clinical effects may take several days to weeks, as it requires metabolism to active forms and accumulation.
Excretion
Excreted primarily in bile and feces, with a small amount excreted in urine.
Half life
Initial half-life of cholecalciferol is about 15-24 hours. The half-life of 25(OH)D (calcifediol) is about 15-30 days, and 1,25(OH)2D (calcitriol) is about 4-6 hours.
Absorption
Well absorbed from the small intestine, primarily in the presence of bile salts and dietary fat. Peak plasma concentrations are reached within 4-5 hours after oral administration.
Metabolism
Primarily metabolized in the liver to 25-hydroxyvitamin D (calcifediol) by 25-hydroxylase, and then in the kidneys to 1,25-dihydroxyvitamin D (calcitriol) by 1-alpha-hydroxylase. Further metabolism occurs to inactive forms.
Side Effects
Contraindications
- •Hypercalcemia (high calcium levels in blood)
- •Hypervitaminosis D (excessive vitamin D levels)
- •Severe renal osteodystrophy with hyperphosphatemia
- •Hypersensitivity to cholecalciferol or any components
Drug Interactions
Digoxin
Increased risk of cardiac arrhythmias if hypercalcemia occurs.
Corticosteroids
May decrease the effects of Vitamin D by inhibiting its metabolism.
Thiazide diuretics
May increase the risk of hypercalcemia due to decreased urinary calcium excretion.
Anticonvulsants (e.g., phenytoin, barbiturates)
May increase vitamin D metabolism, leading to decreased vitamin D levels.
Storage
Store below 30°C in a cool, dry place, protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose (hypervitaminosis D) include hypercalcemia, which can lead to nausea, vomiting, constipation, polyuria, polydipsia, weakness, headache, and in severe cases, renal damage and cardiac arrhythmias. Treatment involves discontinuing Vitamin D, reducing calcium intake, and hydration. Medical intervention may be required.
Pregnancy & Lactation
Vitamin D is essential during pregnancy and lactation. This dosage (400 IU) is generally considered safe and recommended for pregnant and lactating women to maintain adequate levels, under medical supervision. Excessive doses should be avoided.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months (refer to specific product label)
Availability
Pharmacies, supermarkets, online
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in
