Medicine Information

D3

Pediatric Drop200 IU per drop (0.1 ml)Vitamin D preparationsATC: A11CC05

Generic Name

Cholecalciferol 200 IU Pediatric Drop

Manufacturer

Various generic manufacturers

Country

Global

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
d3 200 iu pediatric drop	৳ 75.00	N/A

Description

Overview of the medicine

A vitamin D3 supplement in liquid drop form, specifically designed for infants and young children to prevent and treat vitamin D deficiency and promote healthy bone development.

Uses & Indications

Prevention and treatment of vitamin D deficiency in infants and children

Rickets and osteomalacia prevention and treatment

Support for healthy bone growth and development

Adjuvant therapy for hypocalcemia and hypophosphatemia

Dosage

Adults

Not indicated for adult use; adult formulations of Vitamin D are available.

Elderly

Not indicated for elderly use; elderly formulations of Vitamin D are available.

Renal_impairment

Use with caution in renal impairment; consult a physician for appropriate dosing and monitoring of calcium levels in pediatric patients.

How to Take

Administer orally, directly into the child's mouth or mixed with a small amount of milk, juice, or food. Use the provided dropper for accurate dosing. Do not add to a full bottle of formula or other food, as the child might not consume the entire portion.

Mechanism of Action

Cholecalciferol (Vitamin D3) is a prohormone that is converted in the body to its active form, calcitriol. Calcitriol helps regulate calcium and phosphate levels, promoting their absorption from the gut and deposition into bones, thereby maintaining bone health.

Pharmacokinetics

Onset

Several days to weeks for physiological effects to manifest, peak blood levels of active metabolite within 24-48 hours after a single dose.

Excretion

Primarily excreted in bile and feces; small amounts in urine.

Half life

Parent compound (cholecalciferol): approximately 24 hours. Active metabolite (calcitriol): 3-6 hours. Storage in fat cells can prolong overall effect.

Absorption

Readily absorbed from the small intestine, especially with fatty meals. Bioavailability is enhanced by dietary fats.

Metabolism

Undergoes hydroxylation in the liver to 25-hydroxycholecalciferol (calcidiol), then in the kidneys to 1,25-dihydroxycholecalciferol (calcitriol), the active form.

Side Effects

Contraindications

Hypercalcemia
Hypervitaminosis D
Malabsorption syndrome (unless deficiency is corrected by parental routes)

Drug Interactions

Corticosteroids

May reduce vitamin D effects.

Thiazide diuretics

May increase risk of hypercalcemia.

Mineral oil, Orlistat

May impair vitamin D absorption.

Bile acid sequestrants (e.g., cholestyramine)

May impair vitamin D absorption.

Anticonvulsants (e.g., phenytoin, barbiturates)

May increase vitamin D metabolism, reducing its effectiveness.

Storage

Store below 30°C, away from direct sunlight and moisture. Do not freeze. Keep out of reach of children.

Overdose

Symptoms of overdose include hypercalcemia (nausea, vomiting, loss of appetite, thirst, polyuria, constipation), weakness, and fatigue. Severe cases can lead to renal damage and calcification of soft tissues. Treatment involves discontinuing Vitamin D, hydrating, and managing hypercalcemia.

Pregnancy & Lactation

This is a pediatric product. For adult women, Vitamin D supplementation during pregnancy and lactation is generally safe and often recommended, but should be at appropriate adult dosages under medical supervision.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 ml bottle15 ml bottle

Shelf Life

Typically 2-3 years from manufacturing date; once opened, use within 3-6 months.

Availability

Pharmacies, drugstores, supermarkets

Approval Status

Approved by major regulatory bodies globally

Patent Status

Generic, no longer under patent

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have established the efficacy and safety of Vitamin D3 for deficiency prevention and treatment in pediatric populations. Ongoing research explores optimal dosing and long-term outcomes.

Lab Monitoring

Serum 25(OH)D levels (to assess deficiency and monitor treatment)
Serum calcium levels (to monitor for hypercalcemia, especially with higher doses or prolonged therapy)
Serum phosphate levels
Urinary calcium excretion (in some cases)

Doctor Notes

Emphasize the importance of accurate dosing with the provided dropper.
Advise parents on signs of hypercalcemia and when to seek medical attention.
Recommend regular monitoring of Vitamin D and calcium levels for children on high-dose therapy or with underlying conditions.

Patient Guidelines

Follow the prescribed dosage carefully.
Use the dropper provided for accurate dosing.
Do not exceed the recommended dose without consulting a physician.
Store in a cool, dry place away from direct sunlight.

Missed Dose Advice

If a dose is missed, administer it as soon as remembered, unless it is close to the time for the next scheduled dose. Do not double the dose to make up for a missed one.

Driving Precautions

Not applicable, as this is a pediatric medication and does not affect driving ability.

Lifestyle Advice

Ensure adequate sun exposure for natural Vitamin D synthesis (with appropriate sun protection for infants).
Encourage a balanced diet rich in calcium and vitamin D sources (if appropriate for age).