D3
Generic Name
Cholecalciferol (Vitamin D3)
Manufacturer
Generic Manufacturer
Country
Various
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| d3 200000 iu injectable solution oral im | ৳ 120.00 | N/A |
Description
Overview of the medicine
D3 200,000 IU is a high-dose Cholecalciferol (Vitamin D3) preparation used for the treatment and prevention of Vitamin D deficiency. It can be administered orally or intramuscularly.
Uses & Indications
Dosage
Adults
For severe Vitamin D deficiency: 200,000 IU as a single oral or intramuscular dose, or as per physician's instruction based on deficiency severity and monitoring.
Elderly
Similar to adults, but careful monitoring of calcium levels is recommended due to potential age-related changes in metabolism and excretion.
Renal_impairment
Use with caution. Dosage adjustment may be required based on calcium and phosphate levels. Active form (calcitriol) may be preferred in severe cases.
How to Take
The injectable solution can be administered orally (by drinking the entire content of the ampoule) or by intramuscular injection, as directed by a healthcare professional. Follow instructions for either method carefully.
Mechanism of Action
Cholecalciferol (Vitamin D3) is metabolized in the liver to 25-hydroxycholecalciferol (calcidiol) and then in the kidneys to 1,25-dihydroxycholecalciferol (calcitriol), the active form. Calcitriol regulates calcium and phosphate homeostasis by promoting absorption from the gut, reabsorption in the kidneys, and mobilization from bone.
Pharmacokinetics
Onset
Clinical effects may take several days to weeks to manifest fully.
Excretion
Primarily excreted in bile and feces; a small amount is excreted in urine.
Half life
Parent compound (cholecalciferol) has a half-life of 24-48 hours. The active metabolite (calcitriol) has a half-life of several days.
Absorption
Readily absorbed from the small intestine when administered orally, especially with fatty meals. Rapidly absorbed from the intramuscular injection site.
Metabolism
Hydroxylated in the liver (to calcidiol) and subsequently in the kidneys (to calcitriol).
Side Effects
Contraindications
- •Hypercalcemia (high calcium levels in blood)
- •Hypervitaminosis D (Vitamin D toxicity)
- •Nephrolithiasis (kidney stones)
- •Severe renal impairment
- •Hypersensitivity to cholecalciferol or any excipients.
Drug Interactions
Corticosteroids
May reduce the effects of Vitamin D.
Thiazide diuretics
May increase the risk of hypercalcemia.
Orlistat, Cholestyramine
May impair absorption of fat-soluble vitamins including Vitamin D.
Cardiac glycosides (e.g., Digoxin)
Hypercalcemia induced by Vitamin D may potentiate the toxic effects of cardiac glycosides.
Anticonvulsants (e.g., Phenytoin, Barbiturates)
May increase the metabolism of Vitamin D, requiring higher doses.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose (hypervitaminosis D and hypercalcemia) include nausea, vomiting, constipation, polyuria, polydipsia, weakness, headache, and in severe cases, renal impairment, cardiac arrhythmias, and coma. Management involves immediate discontinuation of Vitamin D, hydration, and medical management of hypercalcemia.
Pregnancy & Lactation
Vitamin D is essential during pregnancy and lactation. However, high doses should only be used under strict medical supervision and careful monitoring of maternal and fetal/infant calcium levels, as excessive intake can be harmful to the fetus/infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, when stored correctly.
Availability
Pharmacies, Hospitals
Approval Status
Generally approved for vitamin supplementation
Patent Status
Generic, off-patent
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Global Brand Names
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