D3
Generic Name
Cholecalciferol (Vitamin D3)
Manufacturer
Various manufacturers
Country
Global
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| d3 20000 iu capsule | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Cholecalciferol (Vitamin D3) 20,000 IU Capsule is a high-strength supplement used to treat and prevent vitamin D deficiency and associated conditions like osteoporosis. Vitamin D is essential for calcium and phosphate absorption, bone health, and immune function.
Uses & Indications
Dosage
Adults
For severe deficiency, 20,000 IU once weekly for 7 weeks, then maintenance dose. Or as directed by physician.
Elderly
Similar to adult dosage, but individual assessment for renal function may be needed.
Renal_impairment
Use with caution. Monitoring of calcium and phosphate levels is crucial. Dosage adjustment may be required.
How to Take
Orally, preferably with the largest meal of the day to enhance absorption, or as directed by the physician.
Mechanism of Action
Cholecalciferol is converted in the liver to 25-hydroxyvitamin D (calcifediol) and then in the kidneys to the active form, 1,25-dihydroxyvitamin D (calcitriol). Calcitriol promotes calcium and phosphate absorption from the gut, regulates bone remodeling, and plays a role in immune modulation.
Pharmacokinetics
Onset
Weeks to months for significant clinical effect, as storage pools are replenished.
Excretion
Mainly excreted in bile/feces; small amounts in urine.
Half life
Vitamin D3 (cholecalciferol): ~24 hours; 25-hydroxyvitamin D: ~2-3 weeks; 1,25-dihydroxyvitamin D: ~4-6 hours.
Absorption
Readily absorbed from the small intestine, primarily in the jejunum and ileum, requiring bile salts for absorption.
Metabolism
Hydroxylated in the liver to 25-hydroxyvitamin D (calcifediol), then further hydroxylated in the kidneys to 1,25-dihydroxyvitamin D (calcitriol).
Side Effects
Contraindications
- •Hypercalcemia
- •Hypervitaminosis D
- •Nephrolithiasis (kidney stones)
- •Severe renal impairment (without proper monitoring)
Drug Interactions
Corticosteroids
May reduce vitamin D effects.
Thiazide diuretics
May increase risk of hypercalcemia.
Phenytoin, Barbiturates
May increase vitamin D metabolism.
Cardiac glycosides (e.g., Digoxin)
Hypercalcemia induced by vitamin D may potentiate digitalis toxicity.
Cholestyramine, Colestipol, Orlistat, Mineral oil
May reduce vitamin D absorption.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms include hypercalcemia (nausea, vomiting, weakness, headache, polyuria, polydipsia, anorexia, lethargy), nephrocalcinosis, and renal impairment. Treatment involves discontinuing vitamin D, low calcium diet, hydration, and potentially corticosteroids.
Pregnancy & Lactation
Safe in recommended doses during pregnancy and lactation. High doses should be avoided due to potential risks of hypercalcemia in the fetus/infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, drugstores
Approval Status
Approved by health authorities worldwide
Patent Status
Generic
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in
