Emixef
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| emixef 100 mg suspension | ৳ 130.00 | N/A |
Description
Overview of the medicine
Emixef 100 mg Suspension is an antibiotic from the cephalosporin group, used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
Not typically used for adults in suspension form; refer to tablet dosage. If used: 400 mg once daily or 200 mg every 12 hours.
Children
8 mg/kg/day, given as a single daily dose or in two divided doses every 12 hours. For 100 mg/5 mL suspension: 0.8 mL/kg/day.
Renal_impairment
Creatinine clearance 21-60 mL/min: 75% of standard dose. Creatinine clearance <20 mL/min: 50% of standard dose.
How to Take
Shake the bottle well before each use. Can be taken with or without food. Complete the full course of treatment as prescribed, even if symptoms improve.
Mechanism of Action
Cefixime is a bactericidal antibiotic. It inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved in 2-6 hours.
Excretion
Primarily excreted unchanged in the urine, with some biliary excretion.
Half life
Average half-life is 3-4 hours, but can be prolonged in renal impairment.
Absorption
Approximately 40-50% absorbed from the gastrointestinal tract. Food can delay absorption but does not significantly affect the extent of absorption.
Metabolism
Not extensively metabolized. A small portion may undergo metabolism.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or other cephalosporins
- History of severe allergic reactions to penicillin
Drug Interactions
Probenecid
May increase cefixime plasma concentrations by decreasing renal excretion.
Carbamazepine
Increased carbamazepine levels have been reported with concomitant cefixime use.
Oral Anticoagulants (e.g., Warfarin)
May increase prothrombin time (INR). Close monitoring of INR is recommended.
Storage
Store dry powder below 30°C, away from light and moisture. Reconstituted suspension should be stored in a refrigerator (2-8°C) and discarded after the recommended period.
Overdose
Gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or other cephalosporins
- History of severe allergic reactions to penicillin
Drug Interactions
Probenecid
May increase cefixime plasma concentrations by decreasing renal excretion.
Carbamazepine
Increased carbamazepine levels have been reported with concomitant cefixime use.
Oral Anticoagulants (e.g., Warfarin)
May increase prothrombin time (INR). Close monitoring of INR is recommended.
Storage
Store dry powder below 30°C, away from light and moisture. Reconstituted suspension should be stored in a refrigerator (2-8°C) and discarded after the recommended period.
Overdose
Gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months for dry powder, 7-14 days for reconstituted suspension (refrigerated).
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of cefixime for its approved indications.
Lab Monitoring
- Renal function (especially in prolonged therapy or renal impairment)
- Complete blood count (rarely in prolonged therapy)
- INR/Prothrombin time (with concomitant anticoagulants)
Doctor Notes
- Advise patients to complete the full course of therapy.
- Counsel on potential C. difficile diarrhea and to seek medical attention if severe.
- Adjust dose for renal impairment.
Patient Guidelines
- Take medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine even if you feel better, as symptoms may return.
- Inform your doctor if you experience severe diarrhea or allergic reactions.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness in some individuals; use caution when driving or operating machinery until you know how it affects you.
Lifestyle Advice
- Stay hydrated by drinking plenty of fluids.
- Maintain good hygiene to prevent further infections.
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Global Brand Names
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