Emixef
Generic Name
Cefixime 400 mg Tablet
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| emixef 400 mg tablet | ৳ 50.00 | ৳ 200.00 |
Description
Overview of the medicine
Emixef 400 mg Tablet is an antibiotic used to treat a variety of bacterial infections. It belongs to the class of cephalosporin antibiotics, which work by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
The usual adult dose is 400 mg once daily or 200 mg every 12 hours. For uncomplicated gonorrhea, a single 400 mg dose is recommended.
Elderly
No dosage adjustment is generally required for elderly patients unless there is significant renal impairment.
Renal_impairment
For patients with creatinine clearance less than 60 mL/min, the dose should be reduced (e.g., 200 mg once daily for CrCl < 60 mL/min; 100 mg once daily for CrCl < 30 mL/min).
How to Take
Emixef 400 mg Tablet should be taken orally, with or without food. It is important to complete the full course of medication as prescribed by the doctor, even if symptoms improve.
Mechanism of Action
Cefixime exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby inhibiting the third and final stage of bacterial cell wall synthesis.
Pharmacokinetics
Onset
Peak plasma concentrations reached 2-6 hours after oral administration.
Excretion
Primarily excreted via the kidneys (renal excretion, approximately 50% unchanged in urine) and also via biliary excretion.
Half life
Approximately 3-4 hours.
Absorption
Approximately 40-50% orally absorbed. Food may delay time to peak concentration but does not significantly alter total absorption.
Metabolism
Not extensively metabolized in the body. No active metabolites identified.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of hypersensitivity to penicillin (due to potential cross-reactivity).
Drug Interactions
Warfarin
May increase prothrombin time (PT) and International Normalized Ratio (INR), increasing bleeding risk. Close monitoring of coagulation parameters is recommended.
Probenecid
May increase cefixime plasma concentrations and prolong its elimination by inhibiting renal excretion.
Carbamazepine
Concomitant administration may increase carbamazepine plasma concentrations. Monitor carbamazepine levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Treatment should be supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use in pregnancy only if clearly needed. Cefixime is excreted in low concentrations in human milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of hypersensitivity to penicillin (due to potential cross-reactivity).
Drug Interactions
Warfarin
May increase prothrombin time (PT) and International Normalized Ratio (INR), increasing bleeding risk. Close monitoring of coagulation parameters is recommended.
Probenecid
May increase cefixime plasma concentrations and prolong its elimination by inhibiting renal excretion.
Carbamazepine
Concomitant administration may increase carbamazepine plasma concentrations. Monitor carbamazepine levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Treatment should be supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use in pregnancy only if clearly needed. Cefixime is excreted in low concentrations in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture, depending on manufacturer specifications.
Availability
Available in pharmacies and hospitals worldwide
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections. Ongoing post-market surveillance contributes to further understanding.
Lab Monitoring
- Renal function tests (for prolonged therapy or in patients with renal impairment)
- Liver function tests (periodically during prolonged therapy)
- Complete Blood Count (CBC) (if therapy is extended)
Doctor Notes
- Emphasize the importance of completing the full course of therapy to prevent resistance.
- Advise patients to report any signs of allergic reactions, particularly skin rashes or difficulty breathing.
- Monitor renal function in elderly patients or those with pre-existing renal impairment.
Patient Guidelines
- Complete the entire course of medication as prescribed, even if you feel better, to prevent recurrence and resistance.
- Do not save medication for future infections or share it with others.
- Contact your doctor if you experience severe diarrhea, rash, or any signs of an allergic reaction.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Cefixime may cause dizziness in some patients. Patients should be advised to be cautious when driving or operating machinery until they know how Emixef affects them.
Lifestyle Advice
- Maintain good hygiene to prevent further infections.
- Drink plenty of fluids to stay hydrated, especially if experiencing diarrhea.
- Avoid alcohol consumption during antibiotic treatment as it may exacerbate side effects.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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