Eusef
Generic Name
Cefuroxime (as Sodium)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| eusef 1 gm injection | ৳ 80.00 | N/A |
Description
Overview of the medicine
Eusef 1 gm Injection contains Cefuroxime, a second-generation cephalosporin antibiotic, used to treat a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
1.5 gm IV/IM every 8 hours for severe infections, or 750 mg IV/IM every 8 hours for less severe infections. For surgical prophylaxis, 1.5 gm IV at induction.
Elderly
No specific dose adjustment required based solely on age, but renal function should be monitored.
Renal_impairment
Dosage adjustment required based on creatinine clearance (e.g., CrCl 10-20 mL/min: 750 mg every 12 hours; CrCl <10 mL/min: 750 mg every 24 hours).
How to Take
Intravenous (IV) or Intramuscular (IM) injection. Reconstitute the powder with sterile water for injection.
Mechanism of Action
Cefuroxime is a bactericidal antibiotic that acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the final transpeptidation step of peptidoglycan synthesis, leading to cell lysis and death.
Pharmacokinetics
Onset
Rapid, typically within 15-30 minutes for IV, 30-60 minutes for IM.
Excretion
Primarily via the kidneys by glomerular filtration and tubular secretion.
Half life
Approximately 1-1.5 hours.
Absorption
Rapidly absorbed after intramuscular administration, good bioavailability.
Metabolism
Not significantly metabolized; mainly excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cefuroxime or other cephalosporins
- History of severe hypersensitivity to any other type of beta-lactam antibacterial agent (e.g., penicillins, carbapenems)
Drug Interactions
Probenecid
Increases cefuroxime levels by reducing renal excretion.
Aminoglycosides
Increased risk of nephrotoxicity.
Oral anticoagulants
May increase anticoagulant effect (e.g., warfarin).
Storage
Store dry powder below 25°C, protected from light and moisture. Do not freeze. Reconstituted solution storage depends on manufacturer instructions.
Overdose
Symptoms of overdose include convulsions and other neurological effects. Treatment is symptomatic and supportive; hemodialysis may be effective.
Pregnancy & Lactation
Use with caution during pregnancy if clearly needed, Category B. Excreted in breast milk in small amounts; generally considered compatible with breastfeeding, but monitor infant for potential side effects (e.g., diarrhea, candidiasis).
Side Effects
Contraindications
- Hypersensitivity to cefuroxime or other cephalosporins
- History of severe hypersensitivity to any other type of beta-lactam antibacterial agent (e.g., penicillins, carbapenems)
Drug Interactions
Probenecid
Increases cefuroxime levels by reducing renal excretion.
Aminoglycosides
Increased risk of nephrotoxicity.
Oral anticoagulants
May increase anticoagulant effect (e.g., warfarin).
Storage
Store dry powder below 25°C, protected from light and moisture. Do not freeze. Reconstituted solution storage depends on manufacturer instructions.
Overdose
Symptoms of overdose include convulsions and other neurological effects. Treatment is symptomatic and supportive; hemodialysis may be effective.
Pregnancy & Lactation
Use with caution during pregnancy if clearly needed, Category B. Excreted in breast milk in small amounts; generally considered compatible with breastfeeding, but monitor infant for potential side effects (e.g., diarrhea, candidiasis).
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years for dry powder, shorter for reconstituted solution (e.g., 24 hours at room temperature, 72 hours under refrigeration).
Availability
Hospitals, Clinics, Pharmacies
Approval Status
Approved by major regulatory bodies
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensively studied and clinically proven for its efficacy in various bacterial infections. Ongoing post-marketing surveillance for safety.
Lab Monitoring
- Renal function (especially in patients with pre-existing impairment)
- Complete blood count (prolonged therapy)
- Liver function tests (if clinically indicated)
Doctor Notes
- Ensure patient history of allergies, especially to beta-lactams, is thoroughly reviewed before administration.
- Monitor renal function in elderly and renally impaired patients.
- Counsel patients on completing the full antibiotic course.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Report any severe or persistent side effects to your doctor.
- Inform your doctor about all medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered, unless it's almost time for the next dose. Do not double the dose.
Driving Precautions
Cefuroxime may cause dizziness in some patients, which could affect the ability to drive or operate machinery. Patients should be cautioned.
Lifestyle Advice
- Maintain good hygiene to prevent further infections.
- Stay hydrated.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Eusef Brand
Other medicines available under the same brand name
