Medicine Information

eusef

Name: eusef
Brand: eusef

Capsule500 mgCephalosporin antibiotics, 3rd generationATC: J01DD08

Generic Name

Cefixime

Manufacturer

XYZ Pharmaceuticals

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
eusef 500 mg capsule	৳ 13.50	৳ 81.00

Description

Overview of the medicine

Eusef 500 mg Capsule contains Cefixime, a third-generation cephalosporin antibiotic, used to treat a wide range of bacterial infections including those of the respiratory tract, urinary tract, and skin.

Uses & Indications

Uncomplicated urinary tract infections (UTIs)

Otitis media

Pharyngitis and tonsillitis

Acute bronchitis and acute exacerbations of chronic bronchitis

Uncomplicated gonorrhea

Bacterial sinusitis

Dosage

Adults

The usual adult dose for Cefixime is 400 mg once daily or 200 mg every 12 hours. For Eusef 500 mg capsule, the dosage should be strictly as prescribed by a physician, potentially 500 mg once daily for severe infections.

Elderly

No dosage adjustment is generally required in elderly patients with normal renal function. For patients with impaired renal function, dosage adjustment is necessary.

Renal_impairment

For creatinine clearance 21-60 mL/min, the dose should be reduced to 300 mg daily. For creatinine clearance <20 mL/min, the dose should be reduced to 200 mg daily. Hemodialysis or peritoneal dialysis patients require 200 mg daily.

How to Take

Eusef 500 mg capsule should be taken orally, with or without food. It is generally recommended to take it at the same time each day to maintain consistent levels in the body.

Mechanism of Action

Cefixime acts by inhibiting bacterial cell wall synthesis, leading to bacterial cell lysis and death. It has a broad spectrum of activity against Gram-positive and Gram-negative bacteria.

Pharmacokinetics

Onset

Peak plasma concentrations are achieved within 2-6 hours after administration.

Excretion

Primarily excreted unchanged in the urine (about 50%) and bile.

Half life

Plasma elimination half-life is typically 3-4 hours.

Absorption

Approximately 40-50% absorbed from the gastrointestinal tract, even in the presence of food.

Metabolism

Not extensively metabolized; about 50% of the absorbed dose is excreted unchanged in urine.

Side Effects

Contraindications

Hypersensitivity to Cefixime or any other cephalosporin antibiotics.
History of severe hypersensitivity reactions to penicillin or other beta-lactam antibiotics.

Drug Interactions

Probenecid

Increases peak plasma concentrations and AUC of cefixime by delaying renal excretion.

Carbamazepine

Concomitant use may increase carbamazepine plasma concentrations.

Warfarin and other anticoagulants

May increase prothrombin time (PT) and INR, enhancing the anticoagulant effect. Close monitoring is advised.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Supportive therapy should be provided.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing woman.

Side Effects

Contraindications

Hypersensitivity to Cefixime or any other cephalosporin antibiotics.
History of severe hypersensitivity reactions to penicillin or other beta-lactam antibiotics.

Drug Interactions

Probenecid

Increases peak plasma concentrations and AUC of cefixime by delaying renal excretion.

Carbamazepine

Concomitant use may increase carbamazepine plasma concentrations.

Warfarin and other anticoagulants

May increase prothrombin time (PT) and INR, enhancing the anticoagulant effect. Close monitoring is advised.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Supportive therapy should be provided.

Pregnancy & Lactation

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 x 10 capsules

Shelf Life

24 months from the date of manufacture.

Availability

Pharmacies, hospitals

Approval Status

Approved

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety in treating a variety of bacterial infections. Ongoing research continues to explore its use and effectiveness.

Lab Monitoring

Renal function tests (e.g., creatinine, BUN) in patients with pre-existing renal impairment or during prolonged therapy.
Complete blood count (CBC) in patients receiving prolonged therapy.

Doctor Notes

Verify patient's allergy history, especially to penicillins and other cephalosporins.
Advise patients to complete the full course of therapy to prevent resistance and recurrence.
Consider renal function adjustment in elderly or renally impaired patients.

Patient Guidelines

Take the medicine for the full prescribed duration, even if symptoms improve.
Do not share this medicine with others, even if they have similar symptoms.
Report any severe side effects or allergic reactions to your doctor immediately.

Missed Dose Advice

If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Cefixime may cause dizziness or lightheadedness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they are certain the drug does not affect them adversely.