Medicine Information

Eusef

Name: Eusef
Brand: Eusef
Rating: 4.5 (117 reviews)

Powder for Injection500 mg3rd Generation CephalosporinsATC: J01DD12

Generic Name

Cefoperazone Sodium

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
eusef 500 mg injection	৳ 50.00	N/A

Description

Overview of the medicine

Eusef 500 mg Injection contains Cefoperazone, a broad-spectrum third-generation cephalosporin antibiotic. It is used to treat a wide range of bacterial infections by stopping the growth of bacteria.

Uses & Indications

Respiratory tract infections

Urinary tract infections

Skin and soft tissue infections

Intra-abdominal infections

Pelvic inflammatory disease

Bacteremia/Septicemia

Dosage

Adults

Typical dose is 2-4 grams daily, given in equally divided doses every 12 hours. For severe infections, the daily dose may be increased up to 12 grams in 2-3 divided doses. For Eusef 500 mg, this implies multiple vials per day.

Elderly

No specific dosage adjustment is generally required based on age alone, but renal and hepatic function should be assessed.

Renal_impairment

In severe renal impairment (creatinine clearance <18 mL/min), the total daily dose should not exceed 4 grams. Monitor serum concentrations in such patients.

How to Take

Eusef Injection can be administered intravenously (IV) via slow infusion over 15-30 minutes, or as an intramuscular (IM) injection. For IM administration, a suitable diluent like sterile water for injection or lidocaine solution (if permitted) should be used.

Mechanism of Action

Cefoperazone inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death. It is bactericidal.

Pharmacokinetics

Onset

Rapid, typically within minutes of IV administration.

Excretion

Approximately 70-80% is excreted in the bile and up to 20-30% via the kidneys.

Half life

Approximately 2 hours in adults with normal renal and hepatic function.

Absorption

Rapidly absorbed after intramuscular (IM) or intravenous (IV) administration. Peak serum concentrations are reached shortly after IV infusion and within 1-2 hours after IM injection.

Metabolism

Minimally metabolized; primarily excreted unchanged.

Side Effects

Contraindications

Known hypersensitivity to cefoperazone or any other cephalosporin antibiotics.
History of severe hypersensitivity reaction to any beta-lactam antibiotic (e.g., penicillins).

Drug Interactions

Alcohol

Disulfiram-like reaction (flushing, sweating, headache, tachycardia) when consumed with alcohol due to inhibition of aldehyde dehydrogenase.

Aminoglycosides

Although generally not nephrotoxic when co-administered, renal function should be monitored, especially in patients with pre-existing renal impairment.

Anticoagulants (e.g., Warfarin)

May enhance the anticoagulant effect by interfering with vitamin K synthesis and platelet function, increasing the risk of bleeding. Monitor INR.

Loop Diuretics (e.g., Furosemide)

Can increase the risk of nephrotoxicity with certain cephalosporins, though less common with cefoperazone. Monitor renal function.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Overdose symptoms may include neurological effects such as convulsions. Management involves symptomatic and supportive treatment, including maintaining airway, breathing, and circulation. Hemodialysis may be useful in removing the drug from the system, especially in patients with impaired renal function.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, use in pregnancy should only be considered if clearly needed. Cefoperazone is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother. Consult your doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 vial of 500 mg Cefoperazone with 1 ampoule of diluent

Shelf Life

24 to 36 months from manufacturing date, depending on specific manufacturer guidelines.

Availability

Pharmacies, Hospitals, Clinics

Approval Status

Approved by DGDA

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Cefoperazone has undergone extensive clinical trials demonstrating its efficacy and safety profile across various bacterial infections. Post-marketing surveillance continues to monitor its use.

Lab Monitoring

Complete Blood Count (CBC) including platelet count, especially during prolonged therapy.
Liver function tests (AST, ALT, ALP, bilirubin).
Renal function tests (creatinine, BUN) for patients with pre-existing renal impairment.
Prothrombin Time (PT) / International Normalized Ratio (INR) for patients at risk of bleeding or on concomitant anticoagulants.

Doctor Notes

Perform culture and sensitivity tests prior to initiating therapy to confirm susceptibility.
Monitor Prothrombin Time (PT) / INR, especially in patients with impaired liver function, poor nutritional status, or those on concomitant anticoagulants.
Educate patients about the importance of avoiding alcohol during and after treatment.

Patient Guidelines

Complete the full course of treatment even if symptoms improve to prevent recurrence and development of antibiotic resistance.
Report any severe or persistent side effects, especially severe diarrhea, to your doctor immediately.
Inform your doctor about all other medications you are taking, including herbal supplements and over-the-counter drugs.
Avoid alcohol while taking this medicine and for at least 72 hours afterward.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.