Flux
Generic Name
Flucloxacillin
Manufacturer
MediCare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| flux 250 mg capsule | ৳ 5.77 | ৳ 23.08 |
Description
Overview of the medicine
Flux 250 mg Capsule contains Flucloxacillin, a penicillin-type antibiotic used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
250-500 mg orally every 6 hours, usually taken 30-60 minutes before food. Max 4g/day.
Elderly
Similar to adult dosage, but caution with renal impairment.
Renal_impairment
Dose adjustment required for severe renal impairment (e.g., CrCl < 10 mL/min, reduce dose or increase interval).
How to Take
Take on an empty stomach, 30-60 minutes before meals, with a glass of water.
Mechanism of Action
Flucloxacillin is a narrow-spectrum beta-lactam antibiotic of the penicillin class. It works by inhibiting bacterial cell wall synthesis, leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
Within 1-2 hours
Excretion
Mainly excreted unchanged in the urine, with some biliary excretion.
Half life
Approximately 0.5-1.5 hours
Absorption
Well absorbed from the gastrointestinal tract, especially when taken on an empty stomach. Peak plasma concentrations reached within 1-2 hours.
Metabolism
Partially metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to penicillins or any component of the formulation
- History of flucloxacillin-associated jaundice/hepatic dysfunction
Drug Interactions
Warfarin
May alter anticoagulant effects; monitor INR closely.
Probenecid
Increases flucloxacillin levels by reducing renal tubular secretion.
Methotrexate
May increase methotrexate toxicity.
Oral Contraceptives
May reduce efficacy of oral contraceptives (though controversial, caution advised).
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose may cause gastrointestinal disturbances, fluid and electrolyte imbalance. Management is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk; caution advised for nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to penicillins or any component of the formulation
- History of flucloxacillin-associated jaundice/hepatic dysfunction
Drug Interactions
Warfarin
May alter anticoagulant effects; monitor INR closely.
Probenecid
Increases flucloxacillin levels by reducing renal tubular secretion.
Methotrexate
May increase methotrexate toxicity.
Oral Contraceptives
May reduce efficacy of oral contraceptives (though controversial, caution advised).
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose may cause gastrointestinal disturbances, fluid and electrolyte imbalance. Management is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk; caution advised for nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Patent expired (Generic available)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of flucloxacillin for its approved indications.
Lab Monitoring
- Liver function tests (especially with prolonged use)
- Renal function tests
- Complete blood count (for prolonged therapy)
Doctor Notes
- Emphasize taking on an empty stomach for optimal absorption.
- Advise patients to complete the full course of antibiotics.
- Counsel on potential hepatic side effects, especially with prolonged use.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Do not share this medicine with others.
- Inform your doctor about any allergies or medical conditions.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Generally does not affect the ability to drive or operate machinery. However, if you experience dizziness, avoid such activities.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Drink plenty of fluids.
- Avoid alcohol during treatment.
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Global Brand Names
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