Flux
Generic Name
Flucloxacillin 500 mg capsule
Manufacturer
PharmaCo Bangladesh Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| flux 500 mg capsule | ৳ 11.50 | ৳ 46.00 |
Description
Overview of the medicine
Flux 500 mg capsule is an antibiotic belonging to the penicillin group. It is used to treat bacterial infections, particularly those caused by penicillinase-producing staphylococci, such as skin and soft tissue infections, bone and joint infections, and respiratory tract infections.
Uses & Indications
Dosage
Adults
Oral: 250-500 mg every 6 hours, usually taken 30-60 minutes before meals. For severe infections, dosage may be increased up to 1 g every 6 hours.
Elderly
Generally, adult dosage can be used, but renal function should be assessed, and dosage adjusted if impairment is present.
Renal_impairment
For creatinine clearance <10 mL/min, reduce dose to 250 mg every 8-12 hours.
How to Take
Take the capsule whole with a glass of water, preferably on an empty stomach (30-60 minutes before food) to ensure optimal absorption. Do not chew or crush the capsule.
Mechanism of Action
Flucloxacillin is a beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). This leads to osmotic instability and bacterial cell lysis. It is resistant to degradation by beta-lactamase enzymes produced by certain bacteria, making it effective against penicillinase-producing staphylococci.
Pharmacokinetics
Onset
Within 1-2 hours (therapeutic effect usually observed within 24-48 hours of starting treatment).
Excretion
Mainly excreted unchanged in the urine, with some biliary excretion.
Half life
Approximately 0.5-1.5 hours in individuals with normal renal function.
Absorption
Well absorbed orally, though food can reduce absorption. Peak plasma concentrations are achieved within 1-2 hours.
Metabolism
Partially metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Known hypersensitivity to flucloxacillin, other penicillins, or any component of the formulation
- History of flucloxacillin-associated jaundice or hepatic dysfunction
- Infectious mononucleosis (may cause skin rash)
Drug Interactions
Warfarin
May increase anticoagulant effect, requiring closer INR monitoring.
Probenecid
Increases and prolongs plasma levels of flucloxacillin by reducing renal tubular secretion.
Methotrexate
May increase methotrexate toxicity due to reduced renal clearance.
Oral Contraceptives
May reduce efficacy of oral contraceptives; advise additional barrier contraception.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include nausea, vomiting, diarrhea, and electrolyte imbalance. In severe cases, neurotoxicity (e.g., convulsions) may occur, especially in patients with impaired renal function. Treatment is supportive and symptomatic; hemodialysis can remove flucloxacillin from the blood.
Pregnancy & Lactation
Pregnancy Category B. Flucloxacillin is generally considered safe during pregnancy when clinically indicated, but use only if clearly needed. Small amounts are excreted in breast milk; generally considered compatible with breastfeeding, but monitor the infant for gastrointestinal disturbances or candidiasis.
Side Effects
Contraindications
- Known hypersensitivity to flucloxacillin, other penicillins, or any component of the formulation
- History of flucloxacillin-associated jaundice or hepatic dysfunction
- Infectious mononucleosis (may cause skin rash)
Drug Interactions
Warfarin
May increase anticoagulant effect, requiring closer INR monitoring.
Probenecid
Increases and prolongs plasma levels of flucloxacillin by reducing renal tubular secretion.
Methotrexate
May increase methotrexate toxicity due to reduced renal clearance.
Oral Contraceptives
May reduce efficacy of oral contraceptives; advise additional barrier contraception.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include nausea, vomiting, diarrhea, and electrolyte imbalance. In severe cases, neurotoxicity (e.g., convulsions) may occur, especially in patients with impaired renal function. Treatment is supportive and symptomatic; hemodialysis can remove flucloxacillin from the blood.
Pregnancy & Lactation
Pregnancy Category B. Flucloxacillin is generally considered safe during pregnancy when clinically indicated, but use only if clearly needed. Small amounts are excreted in breast milk; generally considered compatible with breastfeeding, but monitor the infant for gastrointestinal disturbances or candidiasis.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date
Availability
Available in retail pharmacies and hospitals nationwide
Approval Status
Approved by regulatory authorities in Bangladesh
Patent Status
Expired
WHO Essential Medicine
YesClinical Trials
Flucloxacillin has undergone extensive clinical trials supporting its efficacy and safety profile for the treatment of susceptible bacterial infections. Ongoing post-marketing surveillance continues to monitor its long-term effects.
Lab Monitoring
- Liver function tests (LFTs) especially during prolonged treatment or in patients with pre-existing liver disease
- Renal function tests (e.g., creatinine, BUN) in patients with impaired kidney function
- Complete blood count (CBC) if prolonged therapy is anticipated
Doctor Notes
- Assess renal and hepatic function before initiating and during prolonged therapy.
- Advise patients on the importance of completing the full course of treatment.
- Be aware of potential drug interactions, especially with warfarin and methotrexate.
Patient Guidelines
- Complete the full course of antibiotics even if symptoms improve to prevent resistance.
- Take on an empty stomach, 30-60 minutes before meals.
- Do not share this medicine with others.
- Store in a cool, dry place away from direct sunlight.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Flux 500 mg capsule is not known to impair the ability to drive or operate machinery. However, if you experience dizziness or adverse effects, avoid such activities.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Avoid alcohol consumption during treatment as it may exacerbate side effects.
- Follow a balanced diet.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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