Medicine Information

Flux

Name: Flux
Brand: Flux

Injection250 mgAntibacterial (Systemic)ATC: J01MA12

Generic Name

Fluxone (hypothetical Fluoroquinolone)

Manufacturer

Global Pharma Inc.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
flux 250 mg injection	৳ 25.00	N/A

Description

Overview of the medicine

Flux-250-mg-injection is a broad-spectrum antibiotic belonging to the fluoroquinolone class. It is used to treat a wide range of severe bacterial infections in adults.

Uses & Indications

Complicated urinary tract infections (cUTI)

Community-acquired pneumonia (CAP)

Acute bacterial sinusitis (ABS)

Skin and soft tissue infections (SSTI)

Chronic bacterial prostatitis

Dosage

Adults

250 mg IV once daily, infused over 60 minutes. Duration depends on infection type, typically 7-14 days.

Elderly

No specific dose adjustment for elderly, but monitor renal function and adjust if impaired.

Renal_impairment

Dose reduction necessary for creatinine clearance < 50 mL/min. Consult product leaflet for specific guidelines.

How to Take

Administer as an intravenous (IV) infusion over 60 minutes. Do not administer as a rapid or bolus injection. Dilution may be required before use; follow manufacturer's instructions.

Mechanism of Action

It inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes involved in bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.

Pharmacokinetics

Onset

Within minutes after IV infusion.

Excretion

Primarily excreted unchanged by the kidneys.

Half life

Approximately 6-8 hours.

Absorption

Rapid and complete absorption after intravenous administration (bioavailability 100%).

Metabolism

Minimally metabolized in the liver.

Side Effects

Contraindications

Hypersensitivity to Flux, other fluoroquinolones, or any excipients.
History of tendinopathy or tendon rupture associated with fluoroquinolone use.
Children and adolescents (under 18 years of age) due to risk of joint cartilage damage.
Patients with epilepsy or other CNS disorders that may predispose to seizures.

Drug Interactions

Warfarin

May enhance the anticoagulant effect of warfarin, requiring careful monitoring of INR.

Corticosteroids

Concomitant use may increase the risk of tendon disorders.

Antidiabetic agents

Risk of dysglycemia (hypoglycemia or hyperglycemia).

NSAIDs (Nonsteroidal Anti-inflammatory Drugs)

May increase the risk of CNS stimulation and convulsive seizures.

Storage

Store below 30°C. Protect from light. Do not freeze. Keep out of reach of children.

Overdose

In case of an overdose, symptomatic and supportive treatment should be initiated. Hemodialysis or peritoneal dialysis is not effective in removing significant amounts of Flux from the body.

Pregnancy & Lactation

Not recommended during pregnancy or lactation due to potential risks to the fetus/infant (e.g., arthropathy). Use only if the potential benefit justifies the potential risk, and under strict medical supervision.

Side Effects

Contraindications

Hypersensitivity to Flux, other fluoroquinolones, or any excipients.
History of tendinopathy or tendon rupture associated with fluoroquinolone use.
Children and adolescents (under 18 years of age) due to risk of joint cartilage damage.
Patients with epilepsy or other CNS disorders that may predispose to seizures.

Drug Interactions

Warfarin

May enhance the anticoagulant effect of warfarin, requiring careful monitoring of INR.

Corticosteroids

Concomitant use may increase the risk of tendon disorders.

Antidiabetic agents

Risk of dysglycemia (hypoglycemia or hyperglycemia).

NSAIDs (Nonsteroidal Anti-inflammatory Drugs)

May increase the risk of CNS stimulation and convulsive seizures.

Storage

Store below 30°C. Protect from light. Do not freeze. Keep out of reach of children.

Overdose

In case of an overdose, symptomatic and supportive treatment should be initiated. Hemodialysis or peritoneal dialysis is not effective in removing significant amounts of Flux from the body.

Pregnancy & Lactation

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 x 10 mL vial (250 mg)5 x 10 mL vials (250 mg)

Shelf Life

24 months from the date of manufacture when stored as recommended.

Availability

Available in hospitals and retail pharmacies

Approval Status

Approved by regulatory authorities

Patent Status

Patent expired

WHO Essential Medicine

Yes

Clinical Trials

Extensive Phase I, II, and III clinical trials have demonstrated the efficacy and safety of Flux for its approved indications, comparing it to placebo and other standard antibiotics.

Lab Monitoring

Renal function tests (e.g., serum creatinine, creatinine clearance)
Liver function tests (e.g., ALT, AST)
Complete blood count (CBC) if prolonged therapy
Electrolyte levels (especially potassium and magnesium if QT prolongation risk)

Doctor Notes

Assess renal function prior to and during treatment; adjust dose as necessary.
Educate patients on symptoms of tendinopathy, peripheral neuropathy, and C. difficile.
Avoid in patients with a history of myasthenia gravis or uncontrolled seizure disorders.
Consider ECG monitoring in patients at risk for QT prolongation.

Patient Guidelines

Complete the entire course of treatment as prescribed, even if symptoms improve.
Report any unusual pain, tingling, numbness, or weakness immediately to your doctor.
Avoid excessive sun exposure due to potential photosensitivity.
Inform your doctor about all other medications, including OTC drugs and supplements.

Missed Dose Advice

If a dose is missed, contact your healthcare provider immediately for advice. Do not administer a double dose to make up for a missed dose.

Driving Precautions

This medicine may cause dizziness, lightheadedness, or visual disturbances. Patients should exercise caution when driving or operating machinery until they know how Flux affects them.