Jasocaine
Generic Name
Jasocaine-1-injection
Manufacturer
PharmaLife Inc.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| jasocaine 1 injection | ৳ 23.00 | N/A |
Description
Overview of the medicine
Jasocaine is an amide-type local anesthetic used to produce temporary loss of sensation in a specific area of the body. It works by blocking nerve signals in the body.
Uses & Indications
Dosage
Adults
Dosage varies based on procedure, site, and individual response. Typically, for infiltration: 5-30 mL of 1% solution (max 300 mg). For nerve block: 5-20 mL of 1% solution (max 300 mg). Always use the lowest effective dose.
Elderly
Reduced doses may be required due to decreased hepatic function and sensitivity. Initial dose should be conservative.
Renal_impairment
No specific dose adjustment is generally required for single-dose administration. However, caution is advised with repeated doses or continuous infusion.
How to Take
Administered by healthcare professionals via subcutaneous, intramuscular, or epidural injection, depending on the anesthetic procedure. Not for intravenous use unless specified (e.g., for certain regional blocks by trained personnel).
Mechanism of Action
Jasocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. It primarily acts by blocking voltage-gated sodium channels.
Pharmacokinetics
Onset
Onset of action typically occurs within 2-5 minutes after administration.
Excretion
Metabolites and a small percentage of unchanged drug are excreted via the kidneys.
Half life
Elimination half-life is approximately 1.5 to 3 hours in adults.
Absorption
Rapidly absorbed from injection sites, with peak plasma concentrations occurring within 5-10 minutes depending on the site and vascularity.
Metabolism
Primarily metabolized in the liver by microsomal enzymes via N-dealkylation and hydroxylation.
Side Effects
Contraindications
- Hypersensitivity to jasocaine or other amide-type local anesthetics
- Severe degree of heart block
- Severe hypotension or cardiogenic shock
- Intravenous regional anesthesia in patients with uncontrolled hypertension or severe cardiovascular disease
Drug Interactions
CNS depressants
Additive CNS depressant effects when co-administered with other CNS depressants (e.g., opioids, benzodiazepines).
Antiarrhythmic drugs
Increased risk of cardiac effects (e.g., other Class I antiarrhythmics like mexiletine).
Skeletal muscle relaxants
May potentiate the effect of neuromuscular blocking agents.
Vasoconstrictors (e.g., epinephrine)
Prolongs duration of action and reduces systemic absorption of jasocaine, but also increases risk of local tissue ischemia.
Storage
Store below 30°C. Protect from light and freezing. Do not refrigerate. Keep out of reach of children.
Overdose
Symptoms of overdose include CNS excitation (e.g., tremors, convulsions, anxiety) followed by depression (e.g., drowsiness, respiratory arrest), and cardiovascular effects (e.g., bradycardia, hypotension, cardiac arrest). Management involves supportive care, maintaining airway, administering oxygen, and treating seizures (e.g., with benzodiazepines) and cardiac dysfunction (e.g., IV lipid emulsion).
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefits outweigh the risks. Jasocaine is excreted in breast milk in small amounts; caution should be exercised when administered to a nursing mother. Consult your doctor.
Side Effects
Contraindications
- Hypersensitivity to jasocaine or other amide-type local anesthetics
- Severe degree of heart block
- Severe hypotension or cardiogenic shock
- Intravenous regional anesthesia in patients with uncontrolled hypertension or severe cardiovascular disease
Drug Interactions
CNS depressants
Additive CNS depressant effects when co-administered with other CNS depressants (e.g., opioids, benzodiazepines).
Antiarrhythmic drugs
Increased risk of cardiac effects (e.g., other Class I antiarrhythmics like mexiletine).
Skeletal muscle relaxants
May potentiate the effect of neuromuscular blocking agents.
Vasoconstrictors (e.g., epinephrine)
Prolongs duration of action and reduces systemic absorption of jasocaine, but also increases risk of local tissue ischemia.
Storage
Store below 30°C. Protect from light and freezing. Do not refrigerate. Keep out of reach of children.
Overdose
Symptoms of overdose include CNS excitation (e.g., tremors, convulsions, anxiety) followed by depression (e.g., drowsiness, respiratory arrest), and cardiovascular effects (e.g., bradycardia, hypotension, cardiac arrest). Management involves supportive care, maintaining airway, administering oxygen, and treating seizures (e.g., with benzodiazepines) and cardiac dysfunction (e.g., IV lipid emulsion).
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefits outweigh the risks. Jasocaine is excreted in breast milk in small amounts; caution should be exercised when administered to a nursing mother. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies, Hospitals, Clinics
Approval Status
Approved by DGDA and FDA
Patent Status
Patent Expired
WHO Essential Medicine
YesClinical Trials
Jasocaine has successfully undergone Phase I, II, and III clinical trials demonstrating its efficacy and safety profile for various local anesthetic procedures.
Lab Monitoring
- No routine lab monitoring is required for single-dose administration. In cases of continuous infusion or high doses, monitoring of plasma levels of jasocaine and patient's vital signs may be necessary.
Doctor Notes
- Strict aseptic technique must be observed during administration.
- The maximum recommended dose should not be exceeded to avoid systemic toxicity.
- Careful monitoring for signs of CNS or cardiovascular toxicity is essential, especially after large doses or in vulnerable patients.
Patient Guidelines
- Inform your healthcare provider about any allergies or medical conditions before administration.
- Report any unusual sensations or discomfort during or after the procedure.
- Do not drive or operate machinery until the effects of the anesthetic have worn off completely and you feel alert.
Missed Dose Advice
Jasocaine is administered by a healthcare professional as a single dose or series of doses during a medical procedure. It is not a medication that is taken regularly at home, so a 'missed dose' scenario does not typically apply.
Driving Precautions
Patients should be advised not to drive or operate hazardous machinery until the effects of the local anesthetic have completely resolved and they feel fully alert and coordinated, especially if sedation occurred.
Lifestyle Advice
- Follow post-procedure instructions carefully as advised by your doctor or nurse.
- Avoid alcohol and other CNS depressants immediately after the procedure, as they may enhance sedation.
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