Medicine Information

Jasocaine

Name: Jasocaine
Brand: Jasocaine

Solution for Injection2% (20 mg/mL)Local AnestheticsATC: N01BBXX

Generic Name

Jasocaine 2% Injection

Manufacturer

MediGen Pharma

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
jasocaine 2 injection	৳ 40.00	N/A

Description

Overview of the medicine

Jasocaine 2% Injection is an amide-type local anesthetic used to produce local or regional anesthesia for surgical, diagnostic, and obstetrical procedures.

Uses & Indications

Local infiltration anesthesia

Peripheral nerve blocks

Epidural anesthesia

Spinal anesthesia

Topical anesthesia (off-label)

Dosage

Adults

Individualized based on procedure, site, depth of anesthesia, vascularity, and patient condition. Max single dose typically 4.5 mg/kg (without epinephrine) or 7 mg/kg (with epinephrine), not exceeding 300 mg.

Elderly

Reduced doses recommended due to decreased hepatic metabolism and renal function. Monitor closely.

Renal_impairment

No specific dose adjustment for mild to moderate impairment, but caution advised. Severe impairment may require dose reduction due to metabolite accumulation.

How to Take

Administered by trained healthcare professionals via infiltration, nerve block, epidural, or spinal injection. Do not inject intravenously unless specifically indicated for resuscitation (e.g., ventricular arrhythmias).

Mechanism of Action

Jasocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of nerve impulses, thereby producing local anesthetic action. It primarily blocks voltage-gated sodium channels.

Pharmacokinetics

Onset

2-5 minutes (infiltration), 5-15 minutes (epidural).

Excretion

Primarily excreted by the kidneys as metabolites and less than 10% as unchanged drug.

Half life

Approximately 1.5-2 hours (in adults).

Absorption

Rapidly absorbed from injection sites, extent depends on vascularity of site.

Metabolism

Extensively metabolized in the liver by microsomal enzymes (oxidative N-dealkylation and hydrolysis).

Side Effects

Contraindications

Known hypersensitivity to jasocaine or other amide-type local anesthetics
Severe heart block
Complete atrioventricular block
Hypovolemic shock (for regional anesthesia)

Drug Interactions

Cimetidine

Inhibits hepatic metabolism, increasing jasocaine levels.

Beta-blockers

May reduce hepatic blood flow, leading to decreased metabolism and increased systemic levels of jasocaine.

Neuromuscular blockers

May potentiate the action of neuromuscular blockers.

Antiarrhythmics (Class I)

Additive cardiac depressant effects.

Storage

Store below 30°C. Do not freeze. Protect from light. Keep out of reach of children.

Overdose

Symptoms include CNS effects (dizziness, tinnitus, seizures, respiratory depression) and cardiovascular effects (hypotension, bradycardia, arrhythmias, cardiac arrest). Management involves maintaining airway, ventilation, treating seizures (benzodiazepines), supporting cardiovascular function (vasopressors), and lipid emulsion therapy for severe cases.

Pregnancy & Lactation

Pregnancy Category B. Use with caution during pregnancy; local anesthetics cross the placental barrier. Excreted in breast milk in small amounts, generally considered compatible with breastfeeding with caution.

Side Effects

Contraindications

Known hypersensitivity to jasocaine or other amide-type local anesthetics
Severe heart block
Complete atrioventricular block
Hypovolemic shock (for regional anesthesia)

Drug Interactions

Cimetidine

Inhibits hepatic metabolism, increasing jasocaine levels.

Beta-blockers

May reduce hepatic blood flow, leading to decreased metabolism and increased systemic levels of jasocaine.

Neuromuscular blockers

May potentiate the action of neuromuscular blockers.

Antiarrhythmics (Class I)

Additive cardiac depressant effects.

Storage

Store below 30°C. Do not freeze. Protect from light. Keep out of reach of children.

Overdose

Pregnancy & Lactation

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

2 mL ampoule (20 mg/mL)5 mL vial (20 mg/mL)10 mL vial (20 mg/mL)

Shelf Life

24 months from manufacturing date

Availability

Hospitals, Clinics, Licensed Pharmacies

Approval Status

Approved by Regulatory Authority (e.g., FDA/DGDA)

Patent Status

Under Patent

WHO Essential Medicine

Yes

Clinical Trials

Pre-clinical and clinical studies have demonstrated its efficacy and safety profile as a local anesthetic, similar to established amide-type local anesthetics.

Lab Monitoring

Monitoring of vital signs (heart rate, blood pressure, respiratory rate, oxygen saturation) during and after administration. Serum drug levels if toxicity suspected.

Doctor Notes

Always have resuscitative equipment and drugs readily available when administering local anesthetics.
Aspirate prior to injection to avoid intravascular administration.
Use the lowest effective dose.

Patient Guidelines

Inform your healthcare provider about all your medical conditions and medications.
Report any unusual or severe side effects immediately.
Remain still during the injection procedure.
Avoid sudden movements after the procedure until full sensation returns.

Missed Dose Advice

Not applicable as this is an injection administered by a healthcare professional for a specific procedure.

Driving Precautions

Do not drive or operate machinery until the effects of the local anesthetic have completely worn off and normal sensation and motor function have returned.