Jasocaine
Generic Name
Jasocaine
Manufacturer
Acme Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| jasocaine 10 mg spray | ৳ 300.00 | N/A |
Description
Overview of the medicine
Jasocaine 10 mg spray is a topical local anesthetic used to numb a specific area of the body. It belongs to the amide-type local anesthetics, providing temporary relief from pain or discomfort by blocking nerve signals.
Uses & Indications
Dosage
Adults
Apply 1-3 sprays to the affected area. Do not exceed 10 sprays (100 mg) in a 4-hour period, or 20 sprays (200 mg) in 24 hours. For specific procedures, consult physician for dosage.
Elderly
Use with caution; lower doses may be required due to potential reduced hepatic metabolism and renal clearance. Consult a physician.
Renal_impairment
No specific dosage adjustment for topical use; however, use with caution in severe renal impairment if systemic absorption is a concern.
How to Take
Hold the spray nozzle close to the affected area and press firmly. Do not inhale the spray. Avoid contact with eyes and swallow. Wash hands thoroughly after use.
Mechanism of Action
Jasocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby producing local anesthetic action.
Pharmacokinetics
Onset
2-5 minutes after topical application.
Excretion
Renal excretion, mainly as metabolites; less than 10% of unchanged drug is excreted.
Half life
Approximately 1.5-2 hours (after systemic absorption).
Absorption
Well-absorbed from mucous membranes; absorption from intact skin is minimal but can increase with damaged skin or occlusive dressings.
Metabolism
Primarily hepatic, via CYP1A2 and CYP3A4 enzymes, to active and inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to jasocaine or other amide-type local anesthetics
- Known history of methemoglobinemia
- Application to severely traumatized mucosa or skin where rapid systemic absorption is possible
Drug Interactions
Beta-blockers
May reduce hepatic metabolism of jasocaine, potentially increasing systemic jasocaine levels.
Other local anesthetics
Concurrent use may increase the risk of systemic toxicity.
Antiarrhythmics (Class I)
May increase cardiac toxicity due to additive effects, especially if significant systemic absorption occurs.
Storage
Store below 30°C. Protect from direct sunlight, heat, and ignition sources. Do not puncture or incinerate the canister. Keep out of reach of children. Do not freeze.
Overdose
Symptoms of overdose include central nervous system (CNS) effects (e.g., nervousness, dizziness, blurred vision, tremors, convulsions, drowsiness) and cardiovascular effects (e.g., hypotension, bradycardia, cardiac arrest). Management involves symptomatic and supportive treatment, maintaining airway, and administering anticonvulsants if needed.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefits outweigh the risks. Jasocaine can pass into breast milk; use with caution during lactation and consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to jasocaine or other amide-type local anesthetics
- Known history of methemoglobinemia
- Application to severely traumatized mucosa or skin where rapid systemic absorption is possible
Drug Interactions
Beta-blockers
May reduce hepatic metabolism of jasocaine, potentially increasing systemic jasocaine levels.
Other local anesthetics
Concurrent use may increase the risk of systemic toxicity.
Antiarrhythmics (Class I)
May increase cardiac toxicity due to additive effects, especially if significant systemic absorption occurs.
Storage
Store below 30°C. Protect from direct sunlight, heat, and ignition sources. Do not puncture or incinerate the canister. Keep out of reach of children. Do not freeze.
Overdose
Symptoms of overdose include central nervous system (CNS) effects (e.g., nervousness, dizziness, blurred vision, tremors, convulsions, drowsiness) and cardiovascular effects (e.g., hypotension, bradycardia, cardiac arrest). Management involves symptomatic and supportive treatment, maintaining airway, and administering anticonvulsants if needed.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefits outweigh the risks. Jasocaine can pass into breast milk; use with caution during lactation and consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date when stored under recommended conditions.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by DGDA
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
While specific trials for 'Jasocaine' may be limited, its active component (similar to lidocaine) has been extensively studied in numerous clinical trials for its efficacy and safety as a local anesthetic.
Lab Monitoring
- No routine lab monitoring is generally required for topical Jasocaine 10 mg spray. If systemic toxicity is suspected due to extensive use or overdose, plasma Jasocaine levels and methemoglobin levels might be monitored.
Doctor Notes
- Educate patients on proper spray technique to avoid inhalation and ensure targeted application.
- Emphasize the importance of not exceeding maximum daily dosage to prevent systemic toxicity.
- Counsel patients on recognizing signs of allergic reactions or systemic adverse effects and seeking immediate medical attention if they occur.
- Consider potential drug interactions, especially with other antiarrhythmics or beta-blockers, if significant systemic exposure is anticipated.
Patient Guidelines
- Do not exceed the recommended dosage and frequency of application.
- Avoid applying to broken, inflamed, or extensively damaged skin/mucosa to minimize systemic absorption.
- Wash hands thoroughly after handling the spray.
- If irritation persists or worsens, discontinue use and consult a healthcare professional.
Missed Dose Advice
This is an on-demand medication for symptomatic relief. Apply as needed when symptoms occur, adhering to the maximum dosage limits. There is no concept of a 'missed dose' for this product.
Driving Precautions
Jasocaine 10 mg spray is generally considered safe for driving as systemic absorption is minimal with correct use. However, if symptoms like dizziness or drowsiness occur due to unintended systemic absorption, avoid driving or operating machinery.
Lifestyle Advice
- Keep the affected area clean and dry.
- Avoid scratching or rubbing the treated area to prevent further irritation or infection.
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