Adults

Apply 1-3 sprays to the affected area. Do not exceed 10 sprays (100 mg) in a 4-hour period, or 20 sprays (200 mg) in 24 hours. For specific procedures, consult physician for dosage.

Elderly

Use with caution; lower doses may be required due to potential reduced hepatic metabolism and renal clearance. Consult a physician.

Renal_impairment

No specific dosage adjustment for topical use; however, use with caution in severe renal impairment if systemic absorption is a concern.

Onset

2-5 minutes after topical application.

Excretion

Renal excretion, mainly as metabolites; less than 10% of unchanged drug is excreted.

Half life

Approximately 1.5-2 hours (after systemic absorption).

Absorption

Well-absorbed from mucous membranes; absorption from intact skin is minimal but can increase with damaged skin or occlusive dressings.

Metabolism

Primarily hepatic, via CYP1A2 and CYP3A4 enzymes, to active and inactive metabolites.

Beta-blockers

May reduce hepatic metabolism of jasocaine, potentially increasing systemic jasocaine levels.

Other local anesthetics

Concurrent use may increase the risk of systemic toxicity.

Antiarrhythmics (Class I)

May increase cardiac toxicity due to additive effects, especially if significant systemic absorption occurs.