Jasocaine
Generic Name
Jasocaine 4% Injection
Manufacturer
MediCare Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| jasocaine 4 injection | ৳ 3.74 | N/A |
Description
Overview of the medicine
Jasocaine 4% Injection is a sterile solution containing jasocaine, an amide-type local anesthetic. It is used to produce temporary loss of sensation in a specific area of the body to prevent pain during medical procedures.
Uses & Indications
Dosage
Adults
Dosage varies greatly depending on the procedure, area to be anesthetized, vascularity of tissues, individual tolerance, and technique of anesthesia. Typically, for infiltration, 50-200 mg (1.25-5 mL of 4% solution). Maximum single dose should not exceed 4 mg/kg (280 mg for 70 kg adult).
Elderly
Reduced doses may be required, considering age-related physiological changes and potential comorbidities. Start with lower doses and titrate carefully.
Renal_impairment
No specific dose adjustment for mild to moderate impairment. Use with caution in severe renal impairment, considering potential accumulation of metabolites.
How to Take
Administered via injection (subcutaneous, intradermal, intramuscular, intravenous - only for specific techniques like Bier block, epidural, spinal) by a trained healthcare professional. The specific route and technique depend on the type of anesthesia required.
Mechanism of Action
Jasocaine acts by reversibly blocking the generation and conduction of nerve impulses, primarily by inhibiting the influx of sodium ions through voltage-gated sodium channels in the nerve cell membrane. This prevents the initiation and propagation of action potentials, leading to local anesthesia.
Pharmacokinetics
Onset
Within 2-5 minutes after injection.
Excretion
Mainly excreted via the kidneys, largely as metabolites and a small percentage as unchanged drug.
Half life
Approximately 1.5-2.5 hours.
Absorption
Rapidly absorbed from the site of injection, extent depending on dosage, vascularity of the site, and presence of vasoconstrictors.
Metabolism
Primarily hepatic, by cytochrome P450 enzymes (e.g., CYP1A2, CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to jasocaine or other amide-type local anesthetics.
- Severe heart block (Stokes-Adams syndrome).
- Uncontrolled epilepsy.
- Severe hypotension or shock (for regional anesthesia involving large areas).
Drug Interactions
Other Local Anesthetics
Increased risk of systemic toxicity.
Beta-blockers/Cimetidine
May reduce hepatic metabolism of jasocaine, potentially increasing plasma levels and toxicity.
Antiarrhythmics (e.g., Mexiletine)
Additive cardiac effects, increased risk of cardiotoxicity.
Vasoconstrictors (e.g., Epinephrine)
Prolongs duration of action and reduces systemic absorption, but can increase cardiovascular effects.
Storage
Store below 30°C in a dry place, away from light. Do not freeze.
Overdose
Symptoms of overdose include central nervous system (CNS) excitation (e.g., lightheadedness, numbness of the tongue and lips, tinnitus, visual disturbances, tremors, muscle twitching, convulsions) followed by CNS depression (drowsiness, respiratory depression, coma). Cardiovascular symptoms include hypotension, bradycardia, arrhythmias, and cardiac arrest. Management involves immediate discontinuation, maintaining airway, oxygenation, managing seizures (e.g., with benzodiazepines), and supportive cardiovascular therapy.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. Use during pregnancy should only be considered if the potential benefit justifies the potential risk to the fetus. Jasocaine is excreted into breast milk in small amounts; use with caution in breastfeeding mothers.
Side Effects
Contraindications
- Hypersensitivity to jasocaine or other amide-type local anesthetics.
- Severe heart block (Stokes-Adams syndrome).
- Uncontrolled epilepsy.
- Severe hypotension or shock (for regional anesthesia involving large areas).
Drug Interactions
Other Local Anesthetics
Increased risk of systemic toxicity.
Beta-blockers/Cimetidine
May reduce hepatic metabolism of jasocaine, potentially increasing plasma levels and toxicity.
Antiarrhythmics (e.g., Mexiletine)
Additive cardiac effects, increased risk of cardiotoxicity.
Vasoconstrictors (e.g., Epinephrine)
Prolongs duration of action and reduces systemic absorption, but can increase cardiovascular effects.
Storage
Store below 30°C in a dry place, away from light. Do not freeze.
Overdose
Symptoms of overdose include central nervous system (CNS) excitation (e.g., lightheadedness, numbness of the tongue and lips, tinnitus, visual disturbances, tremors, muscle twitching, convulsions) followed by CNS depression (drowsiness, respiratory depression, coma). Cardiovascular symptoms include hypotension, bradycardia, arrhythmias, and cardiac arrest. Management involves immediate discontinuation, maintaining airway, oxygenation, managing seizures (e.g., with benzodiazepines), and supportive cardiovascular therapy.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. Use during pregnancy should only be considered if the potential benefit justifies the potential risk to the fetus. Jasocaine is excreted into breast milk in small amounts; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Hospitals, Clinics, Licensed Pharmacies
Approval Status
Approved by regulatory authorities
Patent Status
Patent active
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the safety and efficacy of jasocaine as a local anesthetic across various surgical and diagnostic procedures. Ongoing post-market surveillance monitors long-term outcomes.
Lab Monitoring
- No routine lab monitoring required for typical local anesthetic use. Monitor vital signs (heart rate, blood pressure, respiratory rate, oxygen saturation) during and after administration.
Doctor Notes
- Always perform aspiration before injection to avoid intravascular administration.
- Use the lowest effective dose to achieve the desired anesthesia.
- Monitor patient for signs of systemic toxicity, especially after large volumes or highly vascular areas.
- Caution in patients with hepatic impairment, severe cardiovascular disease, or compromised respiratory function.
Patient Guidelines
- Inform your doctor about any allergies or medical conditions before receiving this injection.
- Report any unusual sensations, discomfort, or allergic reactions during or after the procedure.
- Avoid touching or putting pressure on the numb area until sensation returns to prevent accidental injury.
- Follow post-procedure instructions carefully.
Missed Dose Advice
This medicine is administered by a healthcare professional as a single dose or as prescribed for a specific procedure. A missed dose is unlikely, as administration is closely managed in a clinical setting.
Driving Precautions
May cause dizziness or drowsiness. Patients should avoid driving or operating machinery until they are certain they are not affected.
Lifestyle Advice
- Rest as advised by your doctor after the procedure.
- Avoid strenuous activities or alcohol immediately after receiving the injection if you experience drowsiness or dizziness.
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