Kapron
Generic Name
Tranexamic Acid
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
kapron 200 mg injection | ৳ 90.00 | N/A |
Description
Overview of the medicine
Kapron 200 mg Injection contains Tranexamic Acid, an antifibrinolytic agent used to prevent and treat excessive bleeding. It works by inhibiting the breakdown of blood clots.
Uses & Indications
Dosage
Adults
Typically 500-1000 mg (2-5 vials of 200 mg) intravenously, administered slowly at a rate not exceeding 100 mg/minute. Dosage and frequency depend on the condition being treated and patient's response. Often 10-15 mg/kg IV every 6-8 hours.
Elderly
No specific dose adjustment for elderly patients with normal renal function. Monitor renal function.
Renal_impairment
Dose reduction is necessary. For mild impairment (CrCl 50-80 mL/min): 10 mg/kg twice daily. For moderate impairment (CrCl 30-49 mL/min): 10 mg/kg once daily. For severe impairment (CrCl <30 mL/min): 10 mg/kg every 24-48 hours (or as per physician's discretion).
How to Take
Administer slowly by intravenous injection (not more than 100 mg/minute) into a vein. Rapid injection may cause hypotension.
Mechanism of Action
Tranexamic Acid competitively inhibits the activation of plasminogen to plasmin. Plasmin is an enzyme responsible for the breakdown of fibrin clots (fibrinolysis). By inhibiting plasmin, tranexamic acid stabilizes blood clots and prevents their premature dissolution, thereby reducing bleeding.
Pharmacokinetics
Onset
Within minutes after IV administration.
Excretion
Primarily excreted unchanged in the urine via glomerular filtration. Renal excretion accounts for over 95% of the administered dose within 24 hours.
Half life
Approximately 2 to 11 hours (initial phase is rapid, elimination phase is slower).
Absorption
Rapidly absorbed after intravenous administration, with 100% bioavailability.
Metabolism
Minimally metabolized; less than 5% of the dose is metabolized.
Side Effects
Contraindications
- Hypersensitivity to Tranexamic Acid or any component of the formulation
- Active intravascular clotting
- Severe renal impairment (unless dose adjusted)
- History of convulsions
- Subarachnoid hemorrhage (risk of cerebral edema and infarction)
Drug Interactions
Thrombolytic agents
Tranexamic acid may inhibit the effects of thrombolytic agents.
Factor IX Complex Concentrates
Increased risk of thrombotic events.
Combined hormonal contraceptives
May increase the risk of thrombosis.
Anticoagulants (e.g., Warfarin, Heparin)
May counteract the effects of anticoagulants, requiring careful monitoring.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze.
Overdose
Symptoms may include nausea, vomiting, diarrhea, orthostatic hypotension, dizziness, headache, and convulsions. Management includes gastric lavage (if oral overdose), activated charcoal, and supportive treatment. Maintain fluid and electrolyte balance.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Tranexamic acid is excreted in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to Tranexamic Acid or any component of the formulation
- Active intravascular clotting
- Severe renal impairment (unless dose adjusted)
- History of convulsions
- Subarachnoid hemorrhage (risk of cerebral edema and infarction)
Drug Interactions
Thrombolytic agents
Tranexamic acid may inhibit the effects of thrombolytic agents.
Factor IX Complex Concentrates
Increased risk of thrombotic events.
Combined hormonal contraceptives
May increase the risk of thrombosis.
Anticoagulants (e.g., Warfarin, Heparin)
May counteract the effects of anticoagulants, requiring careful monitoring.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze.
Overdose
Symptoms may include nausea, vomiting, diarrhea, orthostatic hypotension, dizziness, headache, and convulsions. Management includes gastric lavage (if oral overdose), activated charcoal, and supportive treatment. Maintain fluid and electrolyte balance.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Tranexamic acid is excreted in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date, refer to packaging.
Availability
Hospitals and pharmacies
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Tranexamic acid has been extensively studied in various clinical trials demonstrating its efficacy in reducing blood loss in surgeries, trauma, and menorrhagia.
Lab Monitoring
- Renal function tests (creatinine, BUN) for long-term use or in patients with renal impairment.
- Periodic eye examinations (including visual acuity and color vision) for long-term use.
- Monitor for signs of thrombosis.
Doctor Notes
- Ensure slow IV administration to avoid hypotension.
- Adjust dose in renal impairment.
- Monitor for signs of thrombosis, especially in patients with pre-existing risk factors.
Patient Guidelines
- Report any unusual bleeding or bruising to your doctor.
- Inform your doctor about any history of blood clots or vision problems.
- Administered by a healthcare professional, do not self-administer.
Missed Dose Advice
If a dose is missed, administer it as soon as you remember, unless it is almost time for your next dose. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hydration as advised by your doctor. Avoid activities that increase the risk of bleeding or injury.
- Follow up with your doctor regularly.
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