Kapron
Generic Name
Tranexamic Acid
Manufacturer
Opsonin Pharma Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| kapron 750 mg tablet | ৳ 18.00 | ৳ 180.00 |
Description
Overview of the medicine
Kapron 750 mg Tablet contains Tranexamic Acid, an antifibrinolytic agent used to prevent and treat excessive bleeding. It works by inhibiting the breakdown of blood clots, thereby promoting hemostasis. It is commonly prescribed for various conditions associated with heavy bleeding, including menorrhagia, nosebleeds, and post-operative hemorrhage.
Uses & Indications
Dosage
Adults
Typically 500 mg to 1000 mg (1-2 tablets of 500mg or 1 tablet of 750mg if available) 2-3 times daily, depending on the indication and severity. For menorrhagia, usually 1000 mg (1.5 tablets of 750mg or 2 tablets of 500mg) three times daily for 3-5 days during menstruation. For other indications, follow physician's advice.
Elderly
Dosage adjustment may be required based on renal function.
Renal_impairment
Dose reduction is necessary based on creatinine clearance (e.g., for CrCl 30-60 mL/min, reduce dose by 50%; for CrCl <30 mL/min, further reduction).
How to Take
Swallow the tablet whole with water. It can be taken with or without food.
Mechanism of Action
Tranexamic acid inhibits the fibrinolytic activity of plasminogen and plasmin. It reversibly binds to the lysine binding sites of plasminogen and plasmin, thereby preventing plasmin from binding to and degrading fibrin, which stabilizes blood clots and reduces bleeding.
Pharmacokinetics
Onset
Within 1-2 hours after oral administration.
Excretion
Primarily via the kidneys (renal excretion).
Half life
Approximately 2-11 hours (dose-dependent).
Absorption
Rapidly absorbed after oral administration. Bioavailability is approximately 30-50%.
Metabolism
Minimally metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Active intravascular clotting
- History of thrombosis or thromboembolic disease (including deep vein thrombosis, pulmonary embolism, cerebral thrombosis)
- Color vision defects (difficulty in distinguishing colors)
- Subarachnoid hemorrhage (unless antifibrinolytic therapy is deemed essential)
- Hypersensitivity to tranexamic acid or any component of the formulation
Drug Interactions
Oral Contraceptives / Estrogens
Increased risk of thrombosis.
Thrombolytic agents (e.g., Alteplase)
Antagonistic effects, reduces efficacy of thrombolytics.
Retinoic acid derivatives (e.g., Tretinoin)
Increased risk of severe thrombotic complications when used with tranexamic acid.
Factor IX complex concentrates / Anti-inhibitor coagulant complexes
Increased risk of thrombosis.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, diarrhea, orthostatic symptoms (e.g., dizziness upon standing), and hypotension. There is a theoretical risk of thrombosis. Management includes gastric lavage, symptomatic treatment, and supportive measures. Maintain adequate hydration and monitor renal function.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of impaired fertility or fetal harm, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Tranexamic acid is excreted in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Active intravascular clotting
- History of thrombosis or thromboembolic disease (including deep vein thrombosis, pulmonary embolism, cerebral thrombosis)
- Color vision defects (difficulty in distinguishing colors)
- Subarachnoid hemorrhage (unless antifibrinolytic therapy is deemed essential)
- Hypersensitivity to tranexamic acid or any component of the formulation
Drug Interactions
Oral Contraceptives / Estrogens
Increased risk of thrombosis.
Thrombolytic agents (e.g., Alteplase)
Antagonistic effects, reduces efficacy of thrombolytics.
Retinoic acid derivatives (e.g., Tretinoin)
Increased risk of severe thrombotic complications when used with tranexamic acid.
Factor IX complex concentrates / Anti-inhibitor coagulant complexes
Increased risk of thrombosis.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, diarrhea, orthostatic symptoms (e.g., dizziness upon standing), and hypotension. There is a theoretical risk of thrombosis. Management includes gastric lavage, symptomatic treatment, and supportive measures. Maintain adequate hydration and monitor renal function.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of impaired fertility or fetal harm, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Tranexamic acid is excreted in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available (off-patent)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials support the efficacy and safety of tranexamic acid for various bleeding disorders, including studies on menorrhagia, trauma, and surgical bleeding.
Lab Monitoring
- Renal function tests (creatinine, BUN) for patients with renal impairment
- Coagulation parameters (PT, aPTT) if relevant to underlying condition
- Eye exams (visual acuity, color vision) for long-term use, especially if visual disturbances occur.
Doctor Notes
- Assess patient's thrombotic risk factors before initiation.
- Monitor for signs of thrombosis (e.g., chest pain, shortness of breath, leg swelling) and visual disturbances.
- Renal dose adjustment is crucial for patients with impaired kidney function.
- Not recommended for routine use in subarachnoid hemorrhage due to risk of cerebral edema and infarction.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine without consulting your doctor, even if you feel better.
- Report any unusual bleeding or vision changes to your doctor immediately.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness or visual disturbances in some patients. If you experience these symptoms, avoid driving or operating machinery.
Lifestyle Advice
- Avoid activities that increase the risk of injury or bleeding.
- Maintain good hydration.
- For menorrhagia, keep track of menstrual flow to assess effectiveness.
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