Kapron
Generic Name
Tranexamic Acid
Manufacturer
ACI Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| kapron 250 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Kapron 250 mg Tablet contains Tranexamic Acid, an antifibrinolytic agent used to prevent and treat excessive bleeding. It works by inhibiting the breakdown of blood clots.
Uses & Indications
Dosage
Adults
General dosage for bleeding is 1000-1500 mg orally 2-3 times daily (4-6 tablets of 250 mg). For menorrhagia, 1000 mg orally 3 times daily (4 tablets of 250 mg) for up to 5 days.
Elderly
No specific dose adjustment necessary unless renal impairment is present.
Renal_impairment
Dosage should be reduced based on creatinine clearance.
How to Take
Swallow the tablet whole with water. It can be taken with or without food.
Mechanism of Action
Tranexamic acid competitively inhibits the activation of plasminogen to plasmin, a molecule responsible for the degradation of fibrin, the main component of blood clots. By inhibiting plasmin, it prevents the breakdown of clots and thereby helps to reduce bleeding.
Pharmacokinetics
Onset
Within 1-2 hours.
Excretion
Mainly excreted unchanged in the urine via glomerular filtration.
Half life
Approximately 2 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is about 30-50%.
Metabolism
Minimally metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Active intravascular clotting
- Subarachnoid hemorrhage
- Severe renal impairment
- Hypersensitivity to tranexamic acid
- History of convulsions
Drug Interactions
Tretinoin
Risk of thrombotic complications.
Combined oral contraceptives
Increased risk of thrombosis.
Factor IX complex concentrates
Increased risk of thrombosis.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, orthostatic symptoms, hypotension, and dizziness. Management is symptomatic and supportive, including gastric lavage and activated charcoal if recent.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefits outweigh the risks. Tranexamic acid passes into breast milk; use with caution during lactation.
Side Effects
Contraindications
- Active intravascular clotting
- Subarachnoid hemorrhage
- Severe renal impairment
- Hypersensitivity to tranexamic acid
- History of convulsions
Drug Interactions
Tretinoin
Risk of thrombotic complications.
Combined oral contraceptives
Increased risk of thrombosis.
Factor IX complex concentrates
Increased risk of thrombosis.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, orthostatic symptoms, hypotension, and dizziness. Management is symptomatic and supportive, including gastric lavage and activated charcoal if recent.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefits outweigh the risks. Tranexamic acid passes into breast milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensively studied for its efficacy in various bleeding conditions, including major trauma, postpartum hemorrhage, and elective surgery.
Lab Monitoring
- Renal function (especially in long-term use)
- Coagulation parameters
- Eye examinations (for visual disturbances with long-term use)
Doctor Notes
- Assess risk factors for thrombosis before initiating treatment.
- Monitor for visual disturbances and renal function in long-term therapy.
- Not recommended for routine use in subarachnoid hemorrhage due to risk of cerebral ischemia.
Patient Guidelines
- Take exactly as prescribed.
- Do not stop taking without consulting your doctor.
- Report any signs of blood clots (e.g., chest pain, difficulty breathing, swelling/pain in a leg) immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances; use caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid prolonged immobility if at risk of thrombosis.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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