Kapron
Generic Name
Tranexamic Acid
Manufacturer
Healthcare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| kapron 500 mg tablet | ৳ 15.00 | ৳ 90.00 |
Description
Overview of the medicine
Kapron 500 mg tablet is primarily used to prevent or treat excessive bleeding in various medical conditions, including heavy menstrual bleeding, nosebleeds, and bleeding after surgery.
Uses & Indications
Dosage
Adults
General dosage for bleeding: 1-1.5 g (2-3 tablets) 2-3 times daily. For menorrhagia: 500 mg (1 tablet) 3 times daily, for up to 3-4 days.
Elderly
No specific dose adjustment is necessary unless there is evidence of renal impairment.
Renal_impairment
Dose reduction required based on creatinine clearance. Consult a physician for specific dosage.
How to Take
Take Kapron 500 mg tablet orally with water, with or without food. Follow the dose and duration as prescribed by your doctor.
Mechanism of Action
Tranexamic acid, the active ingredient in Kapron, acts as an antifibrinolytic. It inhibits the breakdown of blood clots by reversibly binding to plasminogen, preventing its conversion to plasmin. This stabilizes blood clots, thereby reducing bleeding.
Pharmacokinetics
Onset
Clinical effect typically observed within 1-2 hours after oral administration.
Excretion
Primarily excreted via the kidneys as unchanged drug through glomerular filtration.
Half life
Plasma elimination half-life is approximately 2 to 11 hours, significantly prolonged in patients with renal impairment.
Absorption
Well absorbed from the gastrointestinal tract; peak plasma concentrations reached within 3 hours after oral administration.
Metabolism
Minimally metabolized; approximately 95% of the dose is excreted unchanged.
Side Effects
Contraindications
- History of thrombosis (blood clots)
- Severe renal impairment
- Active intravascular clotting
- Subarachnoid hemorrhage (due to risk of cerebral edema and infarction)
- Hypersensitivity to tranexamic acid or any component of the formulation
Drug Interactions
Oral Contraceptives/Estrogens
Increased risk of thrombosis (blood clot formation).
All-trans Retinoic Acid (Tretinoin)
Potential for enhanced procoagulant effects.
Thrombolytic Agents (e.g., Alteplase)
Tranexamic acid counteracts the effects of thrombolytic agents.
Factor IX Complex Concentrates / Anti-inhibitor Coagulant Concentrates
Increased risk of thrombosis.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, orthostatic hypotension, dizziness, headache, and convulsions. Management involves symptomatic and supportive treatment, including gastric lavage if ingested recently.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Tranexamic acid is excreted in breast milk in small amounts; use with caution during lactation.
Side Effects
Contraindications
- History of thrombosis (blood clots)
- Severe renal impairment
- Active intravascular clotting
- Subarachnoid hemorrhage (due to risk of cerebral edema and infarction)
- Hypersensitivity to tranexamic acid or any component of the formulation
Drug Interactions
Oral Contraceptives/Estrogens
Increased risk of thrombosis (blood clot formation).
All-trans Retinoic Acid (Tretinoin)
Potential for enhanced procoagulant effects.
Thrombolytic Agents (e.g., Alteplase)
Tranexamic acid counteracts the effects of thrombolytic agents.
Factor IX Complex Concentrates / Anti-inhibitor Coagulant Concentrates
Increased risk of thrombosis.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, orthostatic hypotension, dizziness, headache, and convulsions. Management involves symptomatic and supportive treatment, including gastric lavage if ingested recently.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Tranexamic acid is excreted in breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, refer to the product label for exact dates.
Availability
Available in pharmacies and hospitals nationwide
Approval Status
DGDA approved
Patent Status
Generic available, off-patent
WHO Essential Medicine
YesClinical Trials
Tranexamic acid has been extensively studied in various clinical trials for its efficacy in reducing bleeding, including the CRASH-2 trial for trauma patients and numerous studies for menorrhagia and surgical bleeding.
Lab Monitoring
- Renal function tests (e.g., serum creatinine, BUN) for dose adjustment in impaired renal function
- Ocular examinations (visual acuity, color vision) for long-term use
- Liver function tests (LFTs) periodically, especially in prolonged use
Doctor Notes
- Emphasize the importance of dose adjustment in patients with renal impairment.
- Advise patients to report any symptoms suggestive of thrombosis or visual disturbances immediately.
- Consider regular ocular examinations for patients on long-term tranexamic acid therapy.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Report any unusual bleeding, bruising, or signs of blood clots (e.g., chest pain, shortness of breath, sudden leg pain/swelling, vision changes) to your doctor immediately.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
- Do not stop taking the medicine suddenly without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Kapron may cause dizziness or visual disturbances in some individuals. If you experience these symptoms, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain good hydration.
- Avoid activities that may increase the risk of bleeding if you are prone to it.
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