Kapron
Generic Name
Tranexamic Acid
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
kapron 250 mg suspension | ৳ 95.00 | N/A |
Description
Overview of the medicine
Kapron 250 mg Suspension contains Tranexamic Acid, an antifibrinolytic agent. It is used to prevent or treat various types of excessive bleeding, often due to enhanced fibrinolysis. This oral suspension form is suitable for children or individuals who have difficulty swallowing tablets.
Uses & Indications
Dosage
Adults
For Menorrhagia: 1-1.5 g (e.g., 2-3 times 250 mg suspensions) three to four times daily for 3-4 days. For other bleeding conditions, dosage varies.
Elderly
Dosage may need adjustment based on renal function.
Renal_impairment
Dosage must be reduced according to creatinine clearance. Refer to specific guidelines.
How to Take
Administer orally with or without food. The suspension should be shaken well before use.
Mechanism of Action
Tranexamic acid acts as an antifibrinolytic by reversibly blocking the lysine binding sites on plasminogen and plasmin, thus preventing their binding to fibrin. This competitive inhibition prevents the conversion of plasminogen to plasmin and inhibits plasmin from degrading fibrin clots, thereby stabilizing the clot and reducing bleeding.
Pharmacokinetics
Onset
1-2 hours
Excretion
Primarily excreted unchanged in the urine
Half life
Approximately 2 hours
Absorption
Rapidly absorbed after oral administration. Bioavailability is about 30-50%.
Metabolism
Minimally metabolized
Side Effects
Contraindications
- Hypersensitivity to tranexamic acid
- Active intravascular clotting (e.g., deep vein thrombosis, pulmonary embolism)
- Subarachnoid hemorrhage
- Severe renal impairment (risk of accumulation)
- History of convulsions
Drug Interactions
Oral Contraceptives
Increased risk of thrombosis.
Thrombolytic agents
Contraindicated (antagonistic effect).
Factor IX Complex Concentrates
Increased risk of thrombosis.
Storage
Store below 30°C in a dry place, away from direct sunlight. Do not freeze. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, diarrhea, hypotension, and thromboembolic events. Management is supportive, including symptomatic treatment and maintaining adequate hydration. Hemodialysis may be considered in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Tranexamic acid is excreted into breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to tranexamic acid
- Active intravascular clotting (e.g., deep vein thrombosis, pulmonary embolism)
- Subarachnoid hemorrhage
- Severe renal impairment (risk of accumulation)
- History of convulsions
Drug Interactions
Oral Contraceptives
Increased risk of thrombosis.
Thrombolytic agents
Contraindicated (antagonistic effect).
Factor IX Complex Concentrates
Increased risk of thrombosis.
Storage
Store below 30°C in a dry place, away from direct sunlight. Do not freeze. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, diarrhea, hypotension, and thromboembolic events. Management is supportive, including symptomatic treatment and maintaining adequate hydration. Hemodialysis may be considered in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Tranexamic acid is excreted into breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date. Once opened, use within 28 days.
Availability
Available in pharmacies, hospitals, and clinics
Approval Status
Approved by regulatory bodies (e.g., DGDA, FDA)
Patent Status
Patent expired, generic versions available
WHO Essential Medicine
YesClinical Trials
Tranexamic acid has been evaluated in numerous clinical trials, demonstrating efficacy in reducing blood loss in various settings, including trauma, surgery, and menorrhagia. Key trials include the WOMAN trial and CRASH-2 trial.
Lab Monitoring
- Regular monitoring of renal function in patients with pre-existing renal impairment
- Ophthalmological examinations (e.g., visual acuity, color vision) if used long-term
Doctor Notes
- Assess patient for a history of thromboembolic disease before initiating therapy.
- Adjust dose in patients with renal impairment.
- Advise patients to report any visual changes or symptoms of thrombosis promptly.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine without consulting your doctor.
- Report any unusual bleeding, vision changes, or signs of blood clots immediately.
- Shake the suspension well before each use.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine may cause visual disturbances or dizziness. If these occur, avoid driving or operating machinery.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid activities that may increase the risk of bleeding if you have a known bleeding disorder.
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Global Brand Names
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