Kilmax
Generic Name
kilmax-15-gm-injection
Manufacturer
MediCorp Pharmaceuticals
Country
United States
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
kilmax 15 gm injection | ৳ 200.00 | N/A |
Description
Overview of the medicine
Kilmax 15 gm Injection is a potent, broad-spectrum antibacterial agent indicated for the treatment of serious and life-threatening infections caused by susceptible Gram-positive and Gram-negative bacteria, including multi-drug resistant strains. Its unique formulation allows for high-dose administration to achieve effective therapeutic concentrations at the site of infection.
Uses & Indications
Dosage
Adults
15 gm once daily, administered as a slow intravenous infusion over 3-4 hours, or divided into 7.5 gm every 12 hours. Duration of treatment depends on the severity and site of infection.
Elderly
No specific dose adjustment required for elderly patients with normal renal function. Monitor renal function closely.
Renal_impairment
Dose adjustment required. For CrCl 30-50 mL/min, 7.5 gm every 24 hours. For CrCl <30 mL/min, 7.5 gm every 48 hours or as guided by therapeutic drug monitoring.
How to Take
For intravenous infusion only. Must be reconstituted and diluted according to package inserts. Administer slowly over at least 3-4 hours to minimize infusion-related reactions. Do not administer as a bolus injection.
Mechanism of Action
Kilmax acts by inhibiting bacterial cell wall synthesis through binding to D-Ala-D-Ala precursors, leading to cell lysis and bacterial death. It also has a secondary mechanism involving disruption of bacterial membrane integrity, contributing to its broad-spectrum activity.
Pharmacokinetics
Onset
Rapid onset, therapeutic levels achieved within minutes of infusion initiation.
Excretion
Primarily renal excretion, with a small percentage excreted through bile.
Half life
Approximately 8-12 hours in patients with normal renal function.
Absorption
Administered intravenously, hence 100% bioavailability. Peak plasma concentrations are reached at the end of infusion.
Metabolism
Minimal hepatic metabolism; primarily excreted as unchanged drug.
Side Effects
Contraindications
- Known hypersensitivity to Kilmax or any of its excipients
- Patients with a history of severe allergic reactions to similar antibiotics
Drug Interactions
Warfarin
Potential for increased anticoagulant effect; monitor INR.
Loop Diuretics
May enhance nephrotoxicity and ototoxicity.
Aminoglycosides
Increased risk of nephrotoxicity and ototoxicity.
Other Nephrotoxic/Ototoxic Drugs
Additive toxicities; avoid concomitant use if possible or monitor closely.
Storage
Store below 25°C (77°F). Do not freeze. Protect from light. Reconstituted solution is stable for 24 hours at 2-8°C (36-46°F).
Overdose
Limited data on overdose. Symptoms may include exaggerated side effects such as severe nephrotoxicity, ototoxicity, and neurological disturbances. Treatment is largely supportive; hemodialysis may be considered for severe cases.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Excreted into breast milk; caution should be exercised when administered to a nursing mother. Consult a physician.
Side Effects
Contraindications
- Known hypersensitivity to Kilmax or any of its excipients
- Patients with a history of severe allergic reactions to similar antibiotics
Drug Interactions
Warfarin
Potential for increased anticoagulant effect; monitor INR.
Loop Diuretics
May enhance nephrotoxicity and ototoxicity.
Aminoglycosides
Increased risk of nephrotoxicity and ototoxicity.
Other Nephrotoxic/Ototoxic Drugs
Additive toxicities; avoid concomitant use if possible or monitor closely.
Storage
Store below 25°C (77°F). Do not freeze. Protect from light. Reconstituted solution is stable for 24 hours at 2-8°C (36-46°F).
Overdose
Limited data on overdose. Symptoms may include exaggerated side effects such as severe nephrotoxicity, ototoxicity, and neurological disturbances. Treatment is largely supportive; hemodialysis may be considered for severe cases.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Excreted into breast milk; caution should be exercised when administered to a nursing mother. Consult a physician.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date when stored unopened.
Availability
Hospital pharmacies and specialized clinics
Approval Status
Approved by regulatory authorities for severe infections
Patent Status
Patented, expected to expire in 2035
Clinical Trials
Phase III trials demonstrated superiority over existing broad-spectrum antibiotics in treating severe hospital-acquired infections. Ongoing post-marketing surveillance studies.
Lab Monitoring
- Renal function tests (serum creatinine, BUN)
- Liver function tests (ALT, AST)
- Complete Blood Count (CBC)
- Therapeutic Drug Monitoring (TDM) for plasma levels
- Audiometry (for prolonged treatment or high-risk patients)
Doctor Notes
- Ensure accurate dosing based on renal function.
- Closely monitor for signs of hypersensitivity and infusion-related reactions.
- Consider therapeutic drug monitoring in critically ill or renally impaired patients.
Patient Guidelines
- Report any signs of allergic reaction immediately.
- Inform healthcare provider about all medications, supplements, and herbal products being taken.
- Report any changes in hearing or balance during treatment.
- Complete the full course of treatment as prescribed, even if symptoms improve.
Missed Dose Advice
If a dose is missed, administer it as soon as possible. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Kilmax may cause dizziness or blurred vision in some patients. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain adequate hydration during treatment.
- Avoid concurrent use of alcohol and other nephrotoxic/ototoxic substances without consulting a doctor.
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