Kilmax
Generic Name
kilmax-15-gm-injection
Manufacturer
MediCorp Pharmaceuticals
Country
United States
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| kilmax 15 gm injection | ৳ 200.00 | N/A |
Description
Overview of the medicine
Kilmax 15 gm Injection is a potent, broad-spectrum antibacterial agent indicated for the treatment of serious and life-threatening infections caused by susceptible Gram-positive and Gram-negative bacteria, including multi-drug resistant strains. Its unique formulation allows for high-dose administration to achieve effective therapeutic concentrations at the site of infection.
Uses & Indications
Dosage
Adults
15 gm once daily, administered as a slow intravenous infusion over 3-4 hours, or divided into 7.5 gm every 12 hours. Duration of treatment depends on the severity and site of infection.
Elderly
No specific dose adjustment required for elderly patients with normal renal function. Monitor renal function closely.
Renal_impairment
Dose adjustment required. For CrCl 30-50 mL/min, 7.5 gm every 24 hours. For CrCl <30 mL/min, 7.5 gm every 48 hours or as guided by therapeutic drug monitoring.
How to Take
For intravenous infusion only. Must be reconstituted and diluted according to package inserts. Administer slowly over at least 3-4 hours to minimize infusion-related reactions. Do not administer as a bolus injection.
Mechanism of Action
Kilmax acts by inhibiting bacterial cell wall synthesis through binding to D-Ala-D-Ala precursors, leading to cell lysis and bacterial death. It also has a secondary mechanism involving disruption of bacterial membrane integrity, contributing to its broad-spectrum activity.
Pharmacokinetics
Onset
Rapid onset, therapeutic levels achieved within minutes of infusion initiation.
Excretion
Primarily renal excretion, with a small percentage excreted through bile.
Half life
Approximately 8-12 hours in patients with normal renal function.
Absorption
Administered intravenously, hence 100% bioavailability. Peak plasma concentrations are reached at the end of infusion.
Metabolism
Minimal hepatic metabolism; primarily excreted as unchanged drug.
Side Effects
Contraindications
- •Known hypersensitivity to Kilmax or any of its excipients
- •Patients with a history of severe allergic reactions to similar antibiotics
Drug Interactions
Warfarin
Potential for increased anticoagulant effect; monitor INR.
Loop Diuretics
May enhance nephrotoxicity and ototoxicity.
Aminoglycosides
Increased risk of nephrotoxicity and ototoxicity.
Other Nephrotoxic/Ototoxic Drugs
Additive toxicities; avoid concomitant use if possible or monitor closely.
Storage
Store below 25°C (77°F). Do not freeze. Protect from light. Reconstituted solution is stable for 24 hours at 2-8°C (36-46°F).
Overdose
Limited data on overdose. Symptoms may include exaggerated side effects such as severe nephrotoxicity, ototoxicity, and neurological disturbances. Treatment is largely supportive; hemodialysis may be considered for severe cases.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Excreted into breast milk; caution should be exercised when administered to a nursing mother. Consult a physician.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date when stored unopened.
Availability
Hospital pharmacies and specialized clinics
Approval Status
Approved by regulatory authorities for severe infections
Patent Status
Patented, expected to expire in 2035
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Global Brand Names
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