Lifcin
Generic Name
Ciprofloxacin
Manufacturer
Local Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lifcin 500 mg tablet | ৳ 15.06 | ৳ 60.24 |
Description
Overview of the medicine
Ciprofloxacin is a fluoroquinolone antibiotic used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
Typical oral dosage for most infections: 250-750 mg twice daily, depending on the severity and type of infection.
Elderly
Generally adult dosage, but renal function should be considered for dose adjustment.
Renal_impairment
Dosage adjustment is necessary for patients with impaired renal function (e.g., reduce dose for CrCl <30 mL/min).
How to Take
Take orally with or without food. Avoid taking with dairy products, calcium-fortified juices, or antacids within 2 hours before or 6 hours after ciprofloxacin.
Mechanism of Action
It works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination.
Pharmacokinetics
Onset
Within 1-2 hours for therapeutic effect.
Excretion
Mainly excreted unchanged in urine (50-70%) and feces (15-30%).
Half life
Approximately 3-5 hours.
Absorption
Rapid and well-absorbed from the gastrointestinal tract after oral administration. Bioavailability is approximately 70%.
Metabolism
Limited hepatic metabolism, primarily through CYP1A2.
Side Effects
Contraindications
- Hypersensitivity to ciprofloxacin or other fluoroquinolones.
- Co-administration with tizanidine.
Drug Interactions
Warfarin
Increased anticoagulant effect, leading to increased bleeding risk.
Tizanidine
Significantly increased tizanidine plasma concentrations, leading to hypotension and somnolence.
Theophylline
Increased plasma levels of theophylline, leading to toxicity.
Antacids/Dairy products
Reduced absorption of ciprofloxacin.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Gastric lavage and activated charcoal may be used. Hemodialysis and peritoneal dialysis remove only a small amount of ciprofloxacin.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Ciprofloxacin is excreted into breast milk; therefore, caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to ciprofloxacin or other fluoroquinolones.
- Co-administration with tizanidine.
Drug Interactions
Warfarin
Increased anticoagulant effect, leading to increased bleeding risk.
Tizanidine
Significantly increased tizanidine plasma concentrations, leading to hypotension and somnolence.
Theophylline
Increased plasma levels of theophylline, leading to toxicity.
Antacids/Dairy products
Reduced absorption of ciprofloxacin.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Gastric lavage and activated charcoal may be used. Hemodialysis and peritoneal dialysis remove only a small amount of ciprofloxacin.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Ciprofloxacin is excreted into breast milk; therefore, caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from the date of manufacture.
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Ciprofloxacin has undergone extensive clinical trials demonstrating its efficacy and safety across various bacterial infections. Ongoing research continues to explore its use against emerging resistant strains and new indications.
Lab Monitoring
- Renal function tests (e.g., serum creatinine, BUN)
- Liver function tests (e.g., ALT, AST)
- Complete blood count
- Blood glucose (especially in diabetic patients)
Doctor Notes
- Counsel patients on the black box warnings, particularly regarding tendinopathy and peripheral neuropathy.
- Monitor renal function, especially in elderly patients and those with pre-existing renal impairment.
- Advise patients to avoid concurrent use with antacids, dairy products, and certain other medications.
- Educate on the importance of completing the full course of treatment.
Patient Guidelines
- Complete the full course of medication even if symptoms improve.
- Avoid excessive sun exposure; use sunscreen and protective clothing.
- Report any pain, swelling, or inflammation of joints or tendons immediately.
- Stay hydrated by drinking plenty of fluids.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Ciprofloxacin may cause dizziness, lightheadedness, or vision disturbances. Patients should be advised to avoid driving or operating machinery if they experience these effects.
Lifestyle Advice
- Maintain good hygiene to prevent further infections.
- Avoid alcohol consumption during treatment if it causes adverse effects.
- Ensure adequate rest to support recovery.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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