Medicine Information

Lifcin

Name: Lifcin
Brand: Lifcin

Tablet750 mgAntibiotics (Fluoroquinolones)ATC: J01MA02

Generic Name

Ciprofloxacin

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
lifcin 750 mg tablet	৳ 20.17	৳ 80.67

Description

Overview of the medicine

Lifcin 750 mg tablet contains Ciprofloxacin, a broad-spectrum fluoroquinolone antibiotic used to treat various bacterial infections.

Uses & Indications

Urinary Tract Infections (UTIs)

Respiratory Tract Infections (e.g., acute exacerbations of chronic bronchitis, pneumonia)

Skin and Soft Tissue Infections

Bone and Joint Infections

Infectious Diarrhea

Typhoid Fever

Anthrax (post-exposure)

Dosage

Adults

Dosage varies by infection severity and type. For severe or complicated infections, 500-750 mg orally twice daily. For uncomplicated UTIs, 250-500 mg orally twice daily.

Elderly

No specific dosage adjustment is required based on age alone, but renal function should be considered.

Renal_impairment

Dosage should be adjusted based on creatinine clearance. For CrCl 30-60 mL/min, 250-500 mg every 12 hours. For CrCl <30 mL/min, 250-500 mg every 18-24 hours.

How to Take

Take the tablet orally with or without food. Do not take with dairy products (milk, yogurt) or calcium-fortified juices alone. Avoid taking with antacids, iron, or zinc preparations within 2 hours before or 6 hours after.

Mechanism of Action

Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes for bacterial DNA replication, transcription, repair, and recombination. This leads to bacterial cell death.

Pharmacokinetics

Onset

Onset of action typically within 1-2 hours.

Excretion

Primarily excreted unchanged by the kidneys (40-50%), with some excretion via the fecal route.

Half life

Plasma elimination half-life is approximately 3-5 hours.

Absorption

Rapid and well-absorbed orally, with bioavailability of approximately 70%. Peak plasma concentrations are reached within 1-2 hours.

Metabolism

Metabolized to a limited extent (10-15%) in the liver. Four active metabolites are formed.

Side Effects

Contraindications

Hypersensitivity to ciprofloxacin or other fluoroquinolones.
Concomitant administration with tizanidine due to increased risk of adverse effects.

Drug Interactions

NSAIDs

May increase CNS stimulation and risk of seizures.

Warfarin

May enhance anticoagulant effect, increasing bleeding risk.

Tizanidine

Contraindicated, leads to increased tizanidine levels and hypotension.

Cyclosporine

May increase cyclosporine nephrotoxicity.

Methotrexate

May increase methotrexate plasma concentrations.

Theophylline

Increases theophylline serum levels, leading to toxicity.

Antacids, sucralfate, iron/zinc supplements

Reduce ciprofloxacin absorption.

Storage

Store below 30°C in a dry place, away from light. Keep out of reach of children.

Overdose

In case of overdose, initiate gastric lavage, provide supportive care, and maintain adequate hydration. Hemodialysis or peritoneal dialysis is not effective in removing ciprofloxacin.

Pregnancy & Lactation

Not recommended during pregnancy or breastfeeding unless the potential benefits outweigh the risks. Ciprofloxacin may cause arthropathy in immature animals.

Side Effects

Contraindications

Hypersensitivity to ciprofloxacin or other fluoroquinolones.
Concomitant administration with tizanidine due to increased risk of adverse effects.

Drug Interactions

NSAIDs

May increase CNS stimulation and risk of seizures.

Warfarin

May enhance anticoagulant effect, increasing bleeding risk.

Tizanidine

Contraindicated, leads to increased tizanidine levels and hypotension.

Cyclosporine

May increase cyclosporine nephrotoxicity.

Methotrexate

May increase methotrexate plasma concentrations.

Theophylline

Increases theophylline serum levels, leading to toxicity.

Antacids, sucralfate, iron/zinc supplements

Reduce ciprofloxacin absorption.

Storage

Store below 30°C in a dry place, away from light. Keep out of reach of children.

Overdose

In case of overdose, initiate gastric lavage, provide supportive care, and maintain adequate hydration. Hemodialysis or peritoneal dialysis is not effective in removing ciprofloxacin.

Pregnancy & Lactation

Not recommended during pregnancy or breastfeeding unless the potential benefits outweigh the risks. Ciprofloxacin may cause arthropathy in immature animals.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 x 10 tablets2 x 10 tablets

Shelf Life

24 to 36 months from manufacturing date.

Availability

Available in pharmacies, hospitals, and clinics

Approval Status

Approved by regulatory authorities (e.g., FDA, DGDA)

Patent Status

Generic

WHO Essential Medicine

Yes

Clinical Trials

Ciprofloxacin has undergone extensive clinical trials demonstrating its efficacy and safety in treating a wide range of bacterial infections.

Lab Monitoring

Renal function (creatinine, BUN)
Liver function tests (ALT, AST) if prolonged therapy
Complete blood count (CBC)

Doctor Notes

Emphasize the importance of completing the full antibiotic course to prevent resistance.
Counsel patients on potential severe side effects like tendinopathy and neuropathy, and advise immediate discontinuation if symptoms occur.
Be aware of drug interactions, especially with tizanidine, warfarin, and antacids.

Patient Guidelines

Complete the full course of treatment, even if symptoms improve.
Avoid direct sunlight and use sun protection as this medicine can increase photosensitivity.
Report any joint pain, swelling, or signs of tendon rupture immediately.
Maintain adequate hydration to prevent crystalluria.
Avoid co-administration with dairy products, antacids, or mineral supplements.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.