Lura
Generic Name
Lurasidone
Manufacturer
Various (e.g., Sunovion, generic manufacturers)
Country
USA (original approval), various countries for generics
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lura 120 mg tablet | ৳ 95.00 | ৳ 570.00 |
Description
Overview of the medicine
Lurasidone is an atypical antipsychotic medication used to treat schizophrenia and major depressive episodes associated with bipolar I disorder. It helps restore the balance of certain natural substances in the brain.
Uses & Indications
Dosage
Adults
Schizophrenia: Initial 40 mg once daily, max 160 mg/day. Bipolar Depression: Initial 20 mg once daily, max 120 mg/day. Always taken with food (at least 350 calories).
Elderly
No specific dose adjustment but use with caution due to increased sensitivity.
Renal_impairment
Moderate to severe (CrCl < 50 mL/min): Max 80 mg/day for schizophrenia, max 60 mg/day for bipolar depression. Hepatic Impairment: Moderate (Child-Pugh B): Max 80 mg/day for schizophrenia, max 60 mg/day for bipolar depression. Severe (Child-Pugh C): Max 40 mg/day for schizophrenia, max 40 mg/day for bipolar depression.
How to Take
Take orally once daily with food (at least 350 calories). Swallow the tablet whole; do not chew, crush, or split.
Mechanism of Action
Lurasidone is believed to exert its therapeutic effect through antagonism at dopamine D2 and serotonin 5-HT2A receptors. It also has affinity for serotonin 5-HT7, 5-HT1A, and α2C-adrenergic receptors.
Pharmacokinetics
Onset
Clinical effects typically observed within a few weeks.
Excretion
Excreted primarily via feces (80%) and urine (9%).
Half life
Elimination half-life is 18 hours.
Absorption
Rapidly absorbed, peak plasma concentrations reached in 1-3 hours. Bioavailability approx. 9-19% when taken with food.
Metabolism
Primarily metabolized by CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to lurasidone or any component of the formulation
- Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir)
- Concomitant use with strong CYP3A4 inducers (e.g., rifampin, carbamazepine, St. John's Wort)
Drug Interactions
CNS Depressants
Enhanced sedative effects (e.g., alcohol, benzodiazepines).
Strong CYP3A4 Inducers
Significantly decrease lurasidone levels. Contraindicated.
Strong CYP3A4 Inhibitors
Significantly increase lurasidone levels. Contraindicated.
Moderate CYP3A4 Inhibitors
Reduce lurasidone dosage (e.g., Diltiazem).
Storage
Store at room temperature (20°C to 25°C); excursions permitted to 15°C to 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
No specific antidote exists. Management should be symptomatic and supportive, including maintaining an adequate airway, oxygenation, and ventilation, and monitoring cardiac function and vital signs.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs potential risk to the fetus. Neonates exposed to antipsychotics during the third trimester are at risk for extrapyramidal and/or withdrawal symptoms. Excreted in breast milk; decision to discontinue nursing or the drug should be made considering the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to lurasidone or any component of the formulation
- Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir)
- Concomitant use with strong CYP3A4 inducers (e.g., rifampin, carbamazepine, St. John's Wort)
Drug Interactions
CNS Depressants
Enhanced sedative effects (e.g., alcohol, benzodiazepines).
Strong CYP3A4 Inducers
Significantly decrease lurasidone levels. Contraindicated.
Strong CYP3A4 Inhibitors
Significantly increase lurasidone levels. Contraindicated.
Moderate CYP3A4 Inhibitors
Reduce lurasidone dosage (e.g., Diltiazem).
Storage
Store at room temperature (20°C to 25°C); excursions permitted to 15°C to 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
No specific antidote exists. Management should be symptomatic and supportive, including maintaining an adequate airway, oxygenation, and ventilation, and monitoring cardiac function and vital signs.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs potential risk to the fetus. Neonates exposed to antipsychotics during the third trimester are at risk for extrapyramidal and/or withdrawal symptoms. Excreted in breast milk; decision to discontinue nursing or the drug should be made considering the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture
Availability
Globally available
Approval Status
FDA Approved
Patent Status
Generics available
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of lurasidone in the treatment of schizophrenia and bipolar depression across various patient populations.
Lab Monitoring
- Blood glucose (fasting) and lipid profile at baseline and periodically
- Weight and BMI at baseline and periodically
- Complete blood count (CBC) if signs of infection or decreased WBC are observed
Doctor Notes
- Monitor for emergent or worsening psychiatric symptoms, particularly suicidality in children, adolescents, and young adults.
- Regular metabolic monitoring (weight, BMI, blood glucose, lipid profile) is crucial due to the risk of metabolic abnormalities.
- Educate patients on the importance of taking lurasidone with a meal of at least 350 calories to optimize absorption and efficacy.
Patient Guidelines
- Take exactly as prescribed by your doctor, with a meal of at least 350 calories.
- Do not stop taking the medicine suddenly without consulting your doctor, as this may lead to withdrawal symptoms or relapse.
- Be aware of potential side effects, especially dizziness and drowsiness, and report any severe or persistent side effects to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double dose to make up for a missed one.
Driving Precautions
Lurasidone may cause drowsiness, dizziness, or impaired judgment. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain a healthy diet and engage in regular physical activity to help manage weight gain, a common side effect of antipsychotics.
- Avoid alcohol consumption and illicit drug use, as they can worsen side effects or interfere with the medication's effectiveness.
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