Lura
Generic Name
Lurasidone
Manufacturer
Major Pharmaceuticals
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lura 80 mg tablet | ৳ 70.00 | ৳ 700.00 |
Description
Overview of the medicine
Lurasidone is an atypical antipsychotic indicated for the treatment of schizophrenia and bipolar depression.
Uses & Indications
Dosage
Adults
Schizophrenia: Initial 40 mg once daily with food; target range 40-160 mg/day. Bipolar depression: Initial 20 mg once daily with food; target range 20-120 mg/day.
Elderly
Lower initial doses and slower titration may be considered. Max dose 80 mg/day (schizophrenia), 60 mg/day (bipolar depression) for patients with moderate-to-severe renal/hepatic impairment.
Renal_impairment
Moderate to severe (CrCl <50 mL/min): Max 80 mg/day (schizophrenia), max 60 mg/day (bipolar depression). No dose adjustment for mild impairment.
How to Take
Take orally once daily with food (at least 350 calories) to ensure proper absorption and reduce gastrointestinal upset.
Mechanism of Action
Lurasidone is an antagonist at dopamine D2 and serotonin 5-HT2A receptors, and a partial agonist at serotonin 5-HT1A receptors. It also has affinity for 5-HT7 and alpha2C-adrenergic receptors.
Pharmacokinetics
Onset
Therapeutic effects may be observed within a few weeks.
Excretion
Primarily excreted via feces (80%), with some renal excretion (9%).
Half life
Approximately 18 hours.
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations reached in 1-3 hours.
Metabolism
Primarily metabolized by CYP3A4.
Side Effects
Contraindications
- Known hypersensitivity to lurasidone or any component of the formulation.
- Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin).
- Concomitant use with strong CYP3A4 inducers (e.g., rifampin, carbamazepine, St. John's Wort).
Drug Interactions
Strong CYP3A4 Inducers
Decreased lurasidone levels (e.g., rifampin, carbamazepine, phenytoin, St. John's Wort). Avoid concomitant use.
Strong CYP3A4 Inhibitors
Increased lurasidone levels (e.g., ketoconazole, clarithromycin, protease inhibitors). Avoid concomitant use.
Moderate CYP3A4 Inhibitors
Lurasidone dose adjustment needed (e.g., diltiazem, erythromycin). Reduce lurasidone dose.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Management includes symptomatic and supportive treatment, including maintaining an open airway, oxygenation, ventilation, and cardiovascular monitoring. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in animal milk and potential for serious adverse reactions in breastfed infants.
Side Effects
Contraindications
- Known hypersensitivity to lurasidone or any component of the formulation.
- Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin).
- Concomitant use with strong CYP3A4 inducers (e.g., rifampin, carbamazepine, St. John's Wort).
Drug Interactions
Strong CYP3A4 Inducers
Decreased lurasidone levels (e.g., rifampin, carbamazepine, phenytoin, St. John's Wort). Avoid concomitant use.
Strong CYP3A4 Inhibitors
Increased lurasidone levels (e.g., ketoconazole, clarithromycin, protease inhibitors). Avoid concomitant use.
Moderate CYP3A4 Inhibitors
Lurasidone dose adjustment needed (e.g., diltiazem, erythromycin). Reduce lurasidone dose.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Management includes symptomatic and supportive treatment, including maintaining an open airway, oxygenation, ventilation, and cardiovascular monitoring. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in animal milk and potential for serious adverse reactions in breastfed infants.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
FDA Approved
Patent Status
Patent Protected
Clinical Trials
Lurasidone has undergone extensive clinical trials demonstrating its efficacy and safety in treating schizophrenia and bipolar depression across various patient populations, including adolescents and adults.
Lab Monitoring
- Fasting plasma glucose and HbA1c (baseline and periodically)
- Lipid panel (baseline and periodically)
- Weight and BMI (baseline and periodically)
- Blood pressure (baseline and periodically)
Doctor Notes
- Emphasize patient education regarding the importance of adherence, recognizing side effects, and avoiding strong CYP3A4 inhibitors/inducers.
- Monitor for metabolic parameters, EPS, and suicidal ideation, especially at the start of treatment or dose changes.
- Consider dose adjustments in renal/hepatic impairment and when co-administering with moderate CYP3A4 inhibitors.
Patient Guidelines
- Take Lura exactly as prescribed by your doctor, do not alter the dose without consultation.
- Always take Lura with food (at least 350 calories).
- Do not stop taking Lura abruptly, even if you feel better, as it can lead to withdrawal symptoms or relapse.
- Avoid alcohol consumption while on Lura.
- Report any unusual muscle movements or fever to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it's almost time for the next dose. Do not take two doses at once or an extra dose.
Driving Precautions
Lura may cause somnolence, dizziness, or impaired motor skills. Avoid driving or operating heavy machinery until you know how this medication affects you.
Lifestyle Advice
- Maintain a healthy diet and exercise regime to manage potential weight gain and metabolic changes.
- Regular communication with your healthcare provider is crucial for monitoring treatment effectiveness and side effects.
- Attend all scheduled appointments for follow-up and lab tests.
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