Lura
Generic Name
Lurasidone
Manufacturer
Generic Pharmaceuticals Inc.
Country
Varies by manufacturer
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lura 40 mg tablet | ৳ 35.00 | ৳ 350.00 |
Description
Overview of the medicine
Lurasidone is an atypical antipsychotic medication used to treat schizophrenia and bipolar depression.
Uses & Indications
Dosage
Adults
Schizophrenia: Initial 40 mg once daily, maximum 160 mg/day. Bipolar Depression: Initial 20 mg once daily, maximum 120 mg/day.
Elderly
Use with caution. Dosage adjustment may be necessary in severe renal or hepatic impairment. Starting dose 20 mg, maximum 80 mg/day (schizophrenia) or 60 mg/day (bipolar depression).
Renal_impairment
Moderate to severe impairment (CrCl < 50 mL/min): Initial 20 mg/day, maximum 80 mg/day for schizophrenia and 60 mg/day for bipolar depression.
How to Take
Take orally once daily with food (at least 350 calories) to ensure adequate absorption.
Mechanism of Action
Lurasidone acts as an antagonist at dopamine D2 and serotonin 5-HT2A receptors, and as a partial agonist at serotonin 5-HT1A receptors. It also acts as an antagonist at alpha2C-adrenergic receptors.
Pharmacokinetics
Onset
Clinical effects typically observed within 1-2 weeks.
Excretion
Primarily via feces (80%) and urine (9%).
Half life
Approximately 18 hours.
Absorption
Well absorbed after oral administration, bioavailability is approximately 9-19%. Must be taken with food (at least 350 calories).
Metabolism
Extensively metabolized by CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to lurasidone or any component of the formulation.
- Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir).
- Concomitant use with strong CYP3A4 inducers (e.g., rifampin, carbamazepine, St. John's Wort).
Drug Interactions
Strong CYP3A4 inducers (e.g., rifampin)
Significantly decreases lurasidone levels; contraindicated.
Moderate CYP3A4 inducers (e.g., efavirenz)
Adjust lurasidone dose, consider increasing initial dose and maximum dose.
Moderate CYP3A4 inhibitors (e.g., diltiazem)
Adjust lurasidone dose, consider reducing initial dose and maximum dose.
Strong CYP3A4 inhibitors (e.g., ketoconazole)
Significantly increases lurasidone levels; contraindicated.
Storage
Store at room temperature (20-25°C or 68-77°F). Protect from moisture and light. Keep out of reach of children.
Overdose
Symptoms include somnolence, sedation, and extrapyramidal symptoms (EPS). Management is supportive, focusing on maintaining airway, monitoring cardiac function, and providing symptomatic treatment.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to fetus. Excreted in breast milk, advise against breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to lurasidone or any component of the formulation.
- Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir).
- Concomitant use with strong CYP3A4 inducers (e.g., rifampin, carbamazepine, St. John's Wort).
Drug Interactions
Strong CYP3A4 inducers (e.g., rifampin)
Significantly decreases lurasidone levels; contraindicated.
Moderate CYP3A4 inducers (e.g., efavirenz)
Adjust lurasidone dose, consider increasing initial dose and maximum dose.
Moderate CYP3A4 inhibitors (e.g., diltiazem)
Adjust lurasidone dose, consider reducing initial dose and maximum dose.
Strong CYP3A4 inhibitors (e.g., ketoconazole)
Significantly increases lurasidone levels; contraindicated.
Storage
Store at room temperature (20-25°C or 68-77°F). Protect from moisture and light. Keep out of reach of children.
Overdose
Symptoms include somnolence, sedation, and extrapyramidal symptoms (EPS). Management is supportive, focusing on maintaining airway, monitoring cardiac function, and providing symptomatic treatment.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to fetus. Excreted in breast milk, advise against breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months, refer to product packaging for exact date.
Availability
Pharmacies, Hospitals
Approval Status
FDA Approved
Patent Status
Generic versions available
Clinical Trials
Lurasidone has undergone extensive clinical trials demonstrating its efficacy and safety in the treatment of schizophrenia and bipolar depression. Key studies include PREVAIL and PEARL trials for schizophrenia, and the PANDORA and HARMONY studies for bipolar depression.
Lab Monitoring
- Fasting glucose and lipid profile (before and during treatment)
- Weight monitoring
- Prolactin levels (if clinically indicated)
- Electrocardiogram (ECG) if cardiac risk factors are present
Doctor Notes
- Monitor for extrapyramidal symptoms (EPS), metabolic parameters (weight, fasting glucose, lipids), and suicidal ideation, especially at the initiation of therapy or after dose changes.
- Counsel patients on the importance of taking the medication with a sufficient amount of food (at least 350 calories) to ensure therapeutic levels.
- Avoid concomitant use with strong CYP3A4 inhibitors and inducers.
Patient Guidelines
- Take with food (at least 350 calories) to ensure proper absorption and effectiveness.
- Do not stop taking the medication abruptly without consulting your doctor.
- Report any unusual muscle movements, fever, severe stiffness, or changes in mental status to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember unless it is almost time for your next scheduled dose. Do not take two doses at once to make up for a missed dose.
Driving Precautions
May cause drowsiness or dizziness; avoid driving or operating heavy machinery until you know how this medication affects you and are confident in your ability to perform such tasks safely.
Lifestyle Advice
- Maintain a healthy diet and exercise regularly to manage potential weight gain and metabolic changes.
- Avoid alcohol as it may worsen central nervous system depressant effects like somnolence and dizziness.
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