Lura
Generic Name
Lurasidone 20 mg tablet
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lura 20 mg tablet | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Lurasidone is an atypical antipsychotic medication used to treat schizophrenia in adults and adolescents (13-17 years of age), and depressive episodes associated with bipolar I disorder in adults.
Uses & Indications
Dosage
Adults
Schizophrenia: Initial dose 40 mg once daily, maximum 160 mg/day. Bipolar Depression: Initial dose 20 mg once daily, maximum 120 mg/day. Administer with food (at least 350 calories).
Elderly
No specific dosage adjustment recommended based solely on age, but caution should be exercised due to potential age-related organ impairments. Start with a lower dose and titrate slowly.
Renal_impairment
Moderate to severe renal impairment (CrCl <50 mL/min): Initial dose 20 mg/day; maximum dose 80 mg/day for schizophrenia, 60 mg/day for bipolar depression. No dose adjustment needed for mild impairment.
How to Take
Take orally once daily with food (at least 350 calories). Taking Lurasidone with food increases its absorption and effectiveness. Do not split, crush, or chew the tablet.
Mechanism of Action
Lurasidone is thought to act as an antagonist at dopamine D2 and serotonin 5-HT2A receptors, and as a partial agonist at serotonin 5-HT1A receptors. It also has antagonistic activity at alpha2C-adrenergic receptors.
Pharmacokinetics
Onset
Clinical improvement can be observed within days to weeks of initiating treatment, with full therapeutic effects taking several weeks.
Excretion
Eliminated primarily through feces (80%) and urine (9%).
Half life
Approximately 18 hours.
Absorption
Well absorbed after oral administration; bioavailability increases significantly with food (at least 350 calories). Peak plasma concentrations reached within 1-3 hours.
Metabolism
Extensively metabolized in the liver, primarily by the cytochrome P450 3A4 (CYP3A4) enzyme system.
Side Effects
Contraindications
- Known hypersensitivity to Lurasidone or any component of the formulation.
- Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir) and strong CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin, St. John's wort).
Drug Interactions
Moderate CYP3A4 inhibitors (e.g., diltiazem)
Reduce lurasidone dose by half.
Moderate CYP3A4 inducers (e.g., bosentan, efavirenz)
Avoid concomitant use.
Strong CYP3A4 inducers (e.g., rifampin, carbamazepine)
Decrease lurasidone plasma concentrations; contraindicated.
Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
Increase lurasidone plasma concentrations; contraindicated.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, sedation, tachycardia, and hypotension. Treatment should be symptomatic and supportive, including maintaining an open airway, oxygenation, and ventilation. Gastric lavage and activated charcoal may be considered. Closely monitor cardiovascular function.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Lurasidone is excreted in breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Known hypersensitivity to Lurasidone or any component of the formulation.
- Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir) and strong CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin, St. John's wort).
Drug Interactions
Moderate CYP3A4 inhibitors (e.g., diltiazem)
Reduce lurasidone dose by half.
Moderate CYP3A4 inducers (e.g., bosentan, efavirenz)
Avoid concomitant use.
Strong CYP3A4 inducers (e.g., rifampin, carbamazepine)
Decrease lurasidone plasma concentrations; contraindicated.
Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
Increase lurasidone plasma concentrations; contraindicated.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, sedation, tachycardia, and hypotension. Treatment should be symptomatic and supportive, including maintaining an open airway, oxygenation, and ventilation. Gastric lavage and activated charcoal may be considered. Closely monitor cardiovascular function.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Lurasidone is excreted in breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years (refer to package for exact date)
Availability
Pharmacies, Hospitals
Approval Status
FDA Approved
Patent Status
Patent protected (original formulation), generics available
Clinical Trials
Lurasidone has undergone extensive clinical trials demonstrating its efficacy and safety for schizophrenia and bipolar depression. Key trials include studies for acute schizophrenia (e.g., PEARL 1, PEARL 2, PREVAIL 1, PREVAIL 2) and bipolar depression (e.g., PREVAIL 3).
Lab Monitoring
- Fasting blood glucose (regularly)
- Lipid panel (regularly)
- Weight (regularly)
- Complete blood count (CBC) if clinically indicated
- Liver and renal function tests (periodically)
Doctor Notes
- Assess for suicidal ideation, particularly at the beginning of treatment or during dose changes, especially in young adults and adolescents.
- Monitor for extrapyramidal symptoms (EPS) and akathisia; manage with dose reduction or anticholinergics if severe.
- Regularly monitor metabolic parameters (weight, glucose, lipids) due to the risk of metabolic syndrome.
- Counsel patients on the importance of taking with food and avoiding CYP3A4 inhibitors/inducers.
Patient Guidelines
- Take Lurasidone with food (at least 350 calories) to ensure proper absorption.
- Do not stop taking the medication abruptly, as this may lead to withdrawal symptoms or a relapse of your condition.
- Report any new or worsening side effects, especially unusual changes in mood or behavior, to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once.
Driving Precautions
Lurasidone may cause drowsiness, dizziness, or impaired judgment. Avoid driving or operating heavy machinery until you know how this medication affects you.
Lifestyle Advice
- Avoid alcohol while taking Lurasidone, as it can increase drowsiness and dizziness.
- Maintain a healthy diet and regular exercise to help manage potential weight gain and metabolic changes.
- Be aware of potential orthostatic hypotension; stand up slowly from a sitting or lying position.
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