Metryl
Generic Name
Metronidazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| metryl 500 mg injection | ৳ 85.50 | N/A |
Description
Overview of the medicine
Metronidazole 500 mg injection is an antimicrobial medication used to treat various bacterial and parasitic infections, particularly those caused by anaerobic bacteria and certain protozoa.
Uses & Indications
Dosage
Adults
For anaerobic infections: Initially 15 mg/kg IV infused over 30-60 minutes, then 7.5 mg/kg IV infused over 30-60 minutes every 6 hours for 7-10 days or longer depending on infection severity. Max 4g/day.
Elderly
No specific dosage adjustment needed, but caution advised due to potential for decreased hepatic function.
Renal_impairment
No dosage adjustment necessary for mild to moderate renal impairment. For severe renal impairment or hemodialysis, consider 50% dose reduction or administration after dialysis.
How to Take
Administer intravenously by slow infusion over 30-60 minutes. Do not administer as a rapid bolus.
Mechanism of Action
Metronidazole enters bacterial and protozoal cells, where its nitro group is reduced by electron transport proteins to reactive cytotoxic compounds. These compounds disrupt DNA structure and inhibit nucleic acid synthesis, leading to cell death.
Pharmacokinetics
Onset
Within hours of administration for clinical effect.
Excretion
Mainly excreted in the urine (60-80%) as parent drug and metabolites; some fecal excretion.
Half life
Approximately 8 hours (range 6-12 hours).
Absorption
Rapidly and almost completely absorbed after IV administration. Peak plasma concentrations are achieved within 1 hour.
Metabolism
Primarily metabolized in the liver by hydroxylation and oxidation, forming active metabolites.
Side Effects
Contraindications
- •Hypersensitivity to metronidazole or other nitroimidazole derivatives.
- •First trimester of pregnancy (relative contraindication).
Drug Interactions
Alcohol
Disulfiram-like reaction (nausea, vomiting, flushing, tachycardia).
Lithium
Increased serum lithium levels, leading to toxicity.
Warfarin
Potentiates anticoagulant effect, monitor INR.
Cimetidine
May prolong metronidazole half-life.
Disulfiram
Psychotic reactions.
Storage
Store below 30°C. Protect from light. Do not freeze.
Overdose
Symptoms may include nausea, vomiting, ataxia, and mild disorientation. Management is supportive and symptomatic; no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Generally avoided in the first trimester. Use with caution during lactation as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years when stored properly.
Availability
Hospitals, Clinics, Retail Pharmacies
Approval Status
Approved by major regulatory bodies globally (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in
