Nyclobate
Generic Name
Clobetasol Propionate 0.05% Shampoo
Manufacturer
Generic Pharma Co.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nyclobate 005 shampoo | ৳ 350.00 | N/A |
Description
Overview of the medicine
Nyclobate 0.05% Shampoo contains Clobetasol Propionate, a potent topical corticosteroid used to treat moderate to severe scalp psoriasis and seborrheic dermatitis of the scalp.
Uses & Indications
Dosage
Adults
Apply a small amount to the affected scalp areas once daily. Lather and leave on for 15 minutes, then rinse thoroughly. Treatment duration should not exceed 4 consecutive weeks.
Elderly
No specific dosage adjustment required, but caution is advised due to potential for increased absorption in elderly patients with thinner skin.
Renal_impairment
No specific dosage adjustment provided, as systemic absorption is minimal.
How to Take
For topical use on the scalp only. Wet hair, apply a small amount to the affected areas, lather, leave for 15 minutes, then rinse thoroughly. Wash hands after use.
Mechanism of Action
Clobetasol Propionate is a highly potent corticosteroid that works by activating natural substances in the skin to reduce swelling, redness, and itching. It suppresses the immune response and reduces inflammation.
Pharmacokinetics
Onset
Effects typically seen within days to a week.
Excretion
Excreted mainly via urine and feces.
Half life
Not well established for topical application; systemic half-life of absorbed clobetasol is about 3-5 hours.
Absorption
Minimal systemic absorption through intact skin; absorption increases with inflammation or occlusion.
Metabolism
Primarily metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Clobetasol Propionate or any other ingredient
- Bacterial, fungal, viral, or parasitic infections of the scalp (unless concomitant anti-infective therapy is used)
- Rosacea
- Perioral dermatitis
- Children under 12 years of age
Drug Interactions
Other topical corticosteroids
Concurrent use may increase systemic absorption and risk of HPA axis suppression.
CYP3A4 inhibitors (e.g., Ritonavir, Itraconazole)
May increase systemic exposure to clobetasol, especially with high dose or prolonged use, leading to increased risk of systemic effects.
Storage
Store at room temperature (below 30°C). Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is unlikely due to the nature of the product. Chronic overdose or misuse can lead to systemic corticosteroid effects like HPA axis suppression, Cushing's syndrome, hyperglycemia, and glucosuria.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Avoid use on large areas or for prolonged periods. Exercise caution when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to Clobetasol Propionate or any other ingredient
- Bacterial, fungal, viral, or parasitic infections of the scalp (unless concomitant anti-infective therapy is used)
- Rosacea
- Perioral dermatitis
- Children under 12 years of age
Drug Interactions
Other topical corticosteroids
Concurrent use may increase systemic absorption and risk of HPA axis suppression.
CYP3A4 inhibitors (e.g., Ritonavir, Itraconazole)
May increase systemic exposure to clobetasol, especially with high dose or prolonged use, leading to increased risk of systemic effects.
Storage
Store at room temperature (below 30°C). Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is unlikely due to the nature of the product. Chronic overdose or misuse can lead to systemic corticosteroid effects like HPA axis suppression, Cushing's syndrome, hyperglycemia, and glucosuria.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Avoid use on large areas or for prolonged periods. Exercise caution when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date
Availability
Pharmacies, Drugstores
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic (Patent expired)
WHO Essential Medicine
YesClinical Trials
Studies have shown Clobetasol Propionate 0.05% shampoo to be effective and safe for treating scalp psoriasis and seborrheic dermatitis in adults.
Lab Monitoring
- Consider HPA axis suppression tests (e.g., ACTH stimulation test, plasma cortisol levels) for prolonged or extensive use, especially in children.
Doctor Notes
- Emphasize limited duration of use (max 4 weeks) to prevent systemic effects and local skin changes.
- Monitor for signs of HPA axis suppression in high-risk patients (e.g., children, large body surface area, occlusive dressings).
- Educate patients on proper application technique and hand washing.
Patient Guidelines
- Use only on the scalp as directed by your doctor.
- Do not use for more than 4 consecutive weeks.
- Avoid contact with eyes, face, and mucous membranes.
- Wash hands immediately after use.
- Do not bandage or cover the treated area unless directed by a doctor.
Missed Dose Advice
If a dose is missed, apply it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular schedule. Do not apply extra shampoo to make up for a missed dose.
Driving Precautions
Nyclobate 0.05% Shampoo is unlikely to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good scalp hygiene.
- Avoid scratching the affected areas to prevent worsening of the condition or infection.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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