Onepro
Generic Name
Pantoprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Description
Overview of the medicine
Onepro (Pantoprazole) is a proton pump inhibitor used to reduce stomach acid production, treating conditions like GERD, peptic ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
For GERD/Erosive Esophagitis: 40 mg once daily for up to 8 weeks. For Duodenal/Gastric Ulcers: 40 mg once daily for 2-4 weeks. For H. pylori eradication: 40 mg twice daily for 7-14 days with antibiotics. For Zollinger-Ellison Syndrome: Initial 40 mg twice daily, adjusted as needed.
Elderly
Generally, no dose adjustment is necessary for elderly patients.
Renal_impairment
No dose adjustment needed for patients with renal impairment.
Hepatic_impairment
For severe hepatic impairment, 20 mg once daily may be sufficient.
How to Take
Take the tablet whole, preferably in the morning before a meal. Do not chew, crush, or split the tablet.
Mechanism of Action
Pantoprazole irreversibly binds to the H+/K+-ATPase enzyme system (proton pump) in the gastric parietal cells, inhibiting the final step in acid production.
Pharmacokinetics
Onset
Within 2.5 hours
Excretion
Primarily via urine (approx. 80%) and feces (approx. 18%) as metabolites.
Half life
Approximately 1 hour (terminal half-life), but duration of acid suppression is much longer.
Absorption
Rapidly absorbed after oral administration, bioavailability about 77%. Peak plasma concentrations reached in 2-2.5 hours.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 system (primarily CYP2C19 and CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to pantoprazole or any component of the formulation.
- Hypersensitivity to other substituted benzimidazoles.
Drug Interactions
Warfarin
Monitor INR if co-administered.
Clopidogrel
Reduced antiplatelet effect of clopidogrel (avoid concomitant use if possible).
Methotrexate
May increase methotrexate levels (monitor carefully).
HIV Antivirals (e.g., Atazanavir)
Reduced absorption of antiretrovirals (avoid concomitant use).
Drugs dependent on gastric pH for absorption (e.g., Ketoconazole, Iron salts)
Reduced absorption due to increased gastric pH.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include lethargy, ataxia, tremor, abdominal pain. Treatment is symptomatic and supportive. Pantoprazole is not significantly removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk, so caution advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole or any component of the formulation.
- Hypersensitivity to other substituted benzimidazoles.
Drug Interactions
Warfarin
Monitor INR if co-administered.
Clopidogrel
Reduced antiplatelet effect of clopidogrel (avoid concomitant use if possible).
Methotrexate
May increase methotrexate levels (monitor carefully).
HIV Antivirals (e.g., Atazanavir)
Reduced absorption of antiretrovirals (avoid concomitant use).
Drugs dependent on gastric pH for absorption (e.g., Ketoconazole, Iron salts)
Reduced absorption due to increased gastric pH.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include lethargy, ataxia, tremor, abdominal pain. Treatment is symptomatic and supportive. Pantoprazole is not significantly removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk, so caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities worldwide
Patent Status
Off-patent (generic versions available)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of pantoprazole in various acid-related disorders.
Lab Monitoring
- Monitor magnesium levels, especially with long-term use (greater than 3 months).
- Monitor Vitamin B12 levels with long-term use (over 2-3 years).
- Consider bone mineral density assessment in patients at risk for osteoporosis with long-term use.
Doctor Notes
- Consider lowest effective dose for shortest duration possible.
- Review need for continued PPI therapy periodically.
- Counsel patients on potential long-term risks.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Swallow tablets whole; do not chew, crush, or break them.
- If symptoms do not improve within 2 weeks, consult your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose.
Driving Precautions
Pantoprazole usually has no effect on the ability to drive or operate machinery. However, if side effects like dizziness or blurred vision occur, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods such as spicy foods, acidic foods, caffeine, and alcohol.
- Eat smaller, more frequent meals.
- Elevate the head of your bed to reduce reflux symptoms.
- Quit smoking.
- Maintain a healthy weight.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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